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Biology and Biochemistry

D-Index
122
Citations
48028
World Ranking
588
National Ranking
377

Overview

Enrique Rozengurt is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on several subfields including Molecular Biology, Oncology, Cell Biology, Immunology, and Surgery.

The scientist's work encompasses a range of topics with notable emphasis on:

  • Hippo pathway signaling and YAP/TAZ
  • Pancreatic and Hepatic Oncology Research
  • Cancer-related Molecular Pathways
  • Phagocytosis and Immune Regulation
  • Cell Adhesion Molecules Research
  • Immune Response and Inflammation
  • Lipid metabolism and biosynthesis

Rozengurt has published extensively in several key venues, frequently contributing to these journals:

  • Cancers
  • The Journal of Immunology
  • American Journal of Transplantation
  • Gastro Hep Advances
  • Gastroenterology

Selected recent papers authored or co-authored by Rozengurt include:

  • "Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance," 2021, Cancers
  • "Obesity and Pancreatic Cancer: Insight into Mechanisms," 2021, Cancers
  • "Metformin: review of epidemiology and mechanisms of action in pancreatic cancer," 2021, Cancer and Metastasis Reviews
  • "Bitter taste receptors as sensors of gut luminal contents," 2024, Nature Reviews Gastroenterology & Hepatology
  • "Metformin inhibition of colorectal cancer cell migration is associated with rebuilt adherens junctions and FAK downregulation," 2020, Journal of Cellular Physiology

Frequent collaborators include:

  • James Sinnett-Smith
  • Elaine F. Reed
  • Yiping Jin
  • Guido Eibl
  • Jessica Nevarez-Mejia

Best Publications

  • Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells.

    Angeles Rodriguez-Pena;Enrique Rozengurt

  • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells

    S. Vincent Wu;Nora Rozengurt;Moon Yang;Steven H. Young

  • Mitogenic signaling pathways induced by G protein‐coupled receptors

    Enrique Rozengurt

  • Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

    Ian Zachary;Enrique Rozengurt

  • Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

    Enrique Rozengurt;James Sinnett-Smith

  • Protein kinase D signaling.

    Enrique Rozengurt;Osvaldo Rey;Richard T. Waldron

  • Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain

    A M Valverde;J Sinnett-Smith;J Van Lint;E Rozengurt

  • Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing.

    Catia Sternini;Laura Anselmi;Enrique Rozengurt

  • Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry

    Jeffrey B. Smith;Enrique Rozengurt

  • Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

    S Rankin;E Rozengurt

  • Serum rapidly stimulates ouabain-sensitive 86-RB+ influx in quiescent 3T3 cells.

    Enrique Rozengurt;Leon A. Heppel

  • Colocalization of the α-subunit of gustducin with PYY and GLP-1 in L cells of human colon

    Nora Rozengurt;S. Vincent Wu;Monica C. Chen;Carlos Huang

  • Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

    I Zachary;J Sinnett-Smith;E Rozengurt

  • Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.

    Krisztina Kisfalvi;Guido Eibl;James Sinnett-Smith;Enrique Rozengurt

  • Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.

    J Sinnett-Smith;I Zachary;A M Valverde;E Rozengurt

  • Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization

    Shimon Schuldiner;Enrique Rozengurt

  • Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer

    Enrique Rozengurt;James Sinnett-Smith;Krisztina Kisfalvi

  • Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance

    Enrique Rozengurt;Heloisa P. Soares;James Sinnet-Smith

  • Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase

    Enrique Rozengurt;Angeles Rodriguez-Pena;Maurice Coombs;James Sinnett-Smith

  • Protein Kinase D Signaling: Multiple Biological Functions in Health and Disease

    Enrique Rozengurt

Frequent Co-Authors

James Sinnett-Smith
James Sinnett-Smith University of California, Los Angeles
Catia Sternini
Catia Sternini University of California, Los Angeles
Elaine F. Reed
Elaine F. Reed University of California, Los Angeles
Joyce Taylor-Papadimitriou
Joyce Taylor-Papadimitriou King's College London
James J. Yoo
James J. Yoo Wake Forest University
Ian Zachary
Ian Zachary University College London
Simon P. Langdon
Simon P. Langdon University of Edinburgh
Dominic J. Withers
Dominic J. Withers Imperial College London
Stephen J. Pandol
Stephen J. Pandol Cedars-Sinai Medical Center
Doreen A. Cantrell
Doreen A. Cantrell University of Dundee

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