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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
104
Citations
36978
World Ranking
1262
National Ranking
18

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Wouter H. Moolenaar is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, with significant work in cell biology, immunology, physiology, and surgery.

The main topics addressed in their research include sphingolipid metabolism and signaling, endoplasmic reticulum stress and disease, phagocytosis and immune regulation, ATP synthase and ATPases research, cellular transport and secretion, peptidase inhibition and analysis, and adenosine and purinergic signaling.

Recent publications by Wouter H. Moolenaar include:

  • Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity, 2021, Journal of Biological Chemistry
  • Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells, 2021, Cell Reports
  • Autotaxin facilitates selective LPA receptor signaling, 2023, Cell chemical biology
  • Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation, 2020, Journal of Cell Science
  • Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis, 2023, Journal of Lipid Research

Frequent co-authors contributing to their work are Anastassis Perrakis, Fernando Salgado-Polo, Elisa Matas-Rico, Razvan Borza, and Andrew J. Morris.

Wouter H. Moolenaar's work has appeared repeatedly in several scholarly venues, including BioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, Cell Reports, Cell chemical biology, and Journal of Cell Science.

Among their recognitions, Wouter H. Moolenaar is a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • The emerging role of lysophosphatidic acid in cancer.

    Gordon B. Mills;Wouter H. Moolenaar

  • Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

    Emile J. van Corven;Alida Groenink;Kees Jalink;Thomas Eichholtz

  • Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

    W. H. Moolenaar;R. Y. Tsien;P. T. van der Saag;S. W. de Laat

  • Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger ∗

    Wouter H. Moolenaar

  • The bioactive phospholipid lysophosphatidic acid is released from activated platelets.

    T Eichholtz;K Jalink;I Fahrenfort;W H Moolenaar

  • Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

    K Jalink;E J van Corven;T Hengeveld;N Morii

  • Growth factor-like action of phosphatidic acid

    W H Moolenaar;W Kruijer;B C Tilly;I Verlaan

  • The ins and outs of lysophosphatidic acid signaling

    Wouter H Moolenaar;Laurens A van Meeteren;Ben N G Giepmans

  • Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.

    Laurens A. van Meeteren;Paula Ruurs;Catelijne Stortelers;Peter Bouwman

  • The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein

    Ben N.G. Giepmans;Wouter H. Moolenaar

  • Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH.

    W. H. Moolenaar;L. G. J. Tertoolen;S. W. de Laat

  • Bioactive lysophospholipids and their G protein-coupled receptors.

    Wouter H. Moolenaar

  • Lysophosphatidic acid: G-protein signalling and cellular responses

    Wouter H Moolenaar;Onno Kranenburg;Friso R Postma;Gerben Cm Zondag

  • International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

    Jerold Chun;Edward J. Goetzl;Timothy Hla;Yasuyuki Igarashi

  • Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

    Masaya Hirose;Toshimasa Ishizaki;Naoki Watanabe;Masayoshi Uehata

  • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

    Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis

  • Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

    W H Moolenaar;L G Tertoolen;S W de Laat

  • Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

    E J van Corven;P L Hordijk;R H Medema;J L Bos

  • Activation of RhoA by Lysophosphatidic Acid and Gα12/13 Subunits in Neuronal Cells: Induction of Neurite Retraction

    Onno Kranenburg;Mieke Poland;Francis P. G. van Horck;David Drechsel

  • Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

    Andreas E. Kremer;Job J.W.W. Martens;Wim Kulik;Franziska Ruëff

Frequent Co-Authors

Kees Jalink
Kees Jalink Antoni van Leeuwenhoek Hospital
S. W. De Laat
S. W. De Laat Utrecht University
Anastassis Perrakis
Anastassis Perrakis Antoni van Leeuwenhoek Hospital
Onno Kranenburg
Onno Kranenburg Utrecht University
Ben N G Giepmans
Ben N G Giepmans University Medical Center Groningen
Leon G.J. Tertoolen
Leon G.J. Tertoolen Leiden University Medical Center
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Wim J. van Blitterswijk
Wim J. van Blitterswijk Antoni van Leeuwenhoek Hospital
Peter L. Hordijk
Peter L. Hordijk University of Amsterdam
Christine L. Mummery
Christine L. Mummery Leiden University Medical Center

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