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Biology and Biochemistry

D-Index
79
Citations
18680
World Ranking
4395
National Ranking
2138

Overview

Gabor Tigyi is affiliated with the University of Tennessee Health Science Center in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in medicine. The main areas of study include molecular biology, cell biology, immunology, physiology, and biochemistry.

The primary topics covered in their work include sphingolipid metabolism and signaling, endoplasmic reticulum stress and disease, lipid membrane structure and behavior, phagocytosis and immune regulation, autophagy in disease and therapy, PI3K/AKT/mTOR signaling in cancer, and receptor mechanisms and signaling.

Frequent publication venues for Gabor Tigyi's research include the International Journal of Molecular Sciences, Cancers, Molecules, Experimental Biology and Medicine, and the Journal of the American Chemical Society.

Collaborations are a significant part of their research output, with frequent co-authors such as Derek D. Norman, Mélanie A. Dacheux, Sue Çhin Lee, Zoltán Benyó, and Kuan-Hung Lin. The number of co-authored publications with these researchers ranges from four to twelve.

Recent papers authored or co-authored by Gabor Tigyi include:

  • Regulation of Tumor Immunity by Lysophosphatidic Acid, 2020, Cancers
  • Optical Control of Lysophosphatidic Acid Signaling, 2020, Journal of the American Chemical Society
  • Evaluation of In-cage Filter Paper as a Replacement for Sentinel Mice in the Detection of Murine Pathogens, 2021, Journal of the American Association for Laboratory Animal Science
  • Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer, 2023, Pharmacology & Therapeutics
  • Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis, 2022, Molecules

Best Publications

  • Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration

    Maxine Lehmann;Alyson Fournier;Immaculada Selles-Navarro;Pauline Dergham

  • Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions.

    Wolfgang Siess;Konrad J. Zangl;Markus Essler;Markus Bauer

  • International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

    Jerold Chun;Edward J. Goetzl;Timothy Hla;Yasuyuki Igarashi

  • Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

    G Tigyi;R Miledi

  • Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood.

    Takamitsu Sano;Daniel L. Baker;Tamas Virag;Atsushi Wada

  • Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils

    Norbert Leitinger;Timothy R. Tyner;Laura Oslund;Cristina Rizza

  • Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques

    Enno Rother;Richard Brandl;Daniel L. Baker;Pankaj Goyal

  • S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.

    Euijung Jo;M. Germana Sanna;Pedro J. Gonzalez-Cabrera;Shobha Thangada

  • Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry.

    Daniel L. Baker;Dominic M. Desiderio;Duane D. Miller;Betsy Tolley

  • Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells.

    Yutaka Yatomi;Tsukasa Ohmori;Tsukasa Ohmori;Ge Rile;Ge Rile;Fuminori Kazama;Fuminori Kazama

  • Lysophosphatidic Acid-Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide-Ca2+ Signaling and Rho

    Gabor Tigyi;David J. Fischer;Ágnes Sebök;Charles Yang

  • Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

    Chunxiang Zhang;Daniel L. Baker;Satoshi Yasuda;Natalia Makarova

  • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

    Francesca Tonelli;Keng Gat Lim;Carolyn Loveridge;Jaclyn Long

  • Molecular mechanisms of lysophosphatidic acid action

    Gabor Tigyi;Abby L. Parrill

  • Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

    Zhong Guo;Károly Liliom;David J. Fischer;Ian C. Bathurst

  • Aiming drug discovery at lysophosphatidic acid targets.

    Gabor Tigyi

  • Lysophosphatidic acid possesses dual action in cell proliferation

    Gabor Tigyi;David L. Dyer;Ricardo Miledi

  • Plasma lysophosphatidic acid concentration and ovarian cancer.

    Daniel L. Baker;Patton Morrison;Brigitte Miller;Caroline A. Riely

  • Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

    Honglu Zhang;Xiaoyu Xu;Joanna Gajewiak;Ryoko Tsukahara

  • The Faciogenital Dysplasia Gene Product FGD1 Functions as a Cdc42Hs-specific Guanine-Nucleotide Exchange Factor

    Yi Zheng;David J. Fischer;Marinilce F. Santos;Gabor Tigyi

Frequent Co-Authors

Yuko Fujiwara
Yuko Fujiwara Harvard University
Duane D. Miller
Duane D. Miller University of Tennessee Health Science Center
Robert Bittman
Robert Bittman City University of New York
Ricardo Miledi
Ricardo Miledi University of California, Irvine
Glenn D. Prestwich
Glenn D. Prestwich University of Utah
Wolfgang Siess
Wolfgang Siess Ludwig-Maximilians-Universität München
Nigel J. Pyne
Nigel J. Pyne University of Strathclyde
Susan Pyne
Susan Pyne University of Strathclyde
Dominic M. Desiderio
Dominic M. Desiderio University of Tennessee Health Science Center
Yasuyuki Igarashi
Yasuyuki Igarashi Hokkaido University

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