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Biology and Biochemistry

D-Index
70
Citations
13885
World Ranking
7171
National Ranking
546

Overview

Nigel J. Pyne is affiliated with the University of Strathclyde in the United Kingdom and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology and cell biology, with significant work in immunology, physiology, and public health topics.

The main topics of their research include sphingolipid metabolism and signaling, lipid membrane structure and behavior, and endoplasmic reticulum stress and disease. They have also contributed to studies in acute lymphoblastic leukemia, immune cell function and interaction, erythrocyte function and pathophysiology, and enzyme function and inhibition.

Nigel J. Pyne has published in several well-known scientific journals. Frequent publication venues include:

  • British Journal of Pharmacology
  • Cellular Signalling
  • FEBS Letters
  • Nature Communications
  • Cells

Notable recent papers include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Enzymes, 2023, British Journal of Pharmacology
  • Recent advances in the role of sphingosine 1-phosphate in cancer, 2020, FEBS Letters
  • Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia, 2021, Nature Communications
  • Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1, 2020, Cells

The scientist collaborates frequently with several colleagues, including:

  • Susan Pyne
  • David R. Adams
  • Jeongah Oh
  • Federico Torta
  • S P H Alexander

Nigel J. Pyne's work notably spans enzyme research and lipid-related signaling pathways, with an emphasis on understanding cellular mechanisms related to disease processes such as cancer and leukemia. Their publication record includes contributions to comprehensive pharmacological guides alongside more specialized research articles.

Best Publications

  • Sphingosine 1-phosphate and cancer.

    Nigel J. Pyne;Susan Pyne

  • Sphingosine 1-phosphate signalling in mammalian cells

    Susan Pyne;Nigel J. Pyne

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

    Stephen P.H. Alexander;Doriano Fabbro;Eamonn Kelly;Alistair Mathie

  • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

    Francesca Tonelli;Keng Gat Lim;Carolyn Loveridge;Jaclyn Long

  • Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.

    Susan Pyne;Nigel Pyne

  • High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

    Carol Watson;Jaclyn S. Long;Clare Orange;Claire L. Tannahill

  • Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

    Forbes Alderton;Soma Rakhit;Kok Choi Kong;Timothy Palmer

  • Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

    Susan Pyne;David R. Adams;Nigel J. Pyne

  • The Concise Guide to PHARMACOLOGY 2013/14: overview

    Stephen P.H. Alexander;Helen E. Benson;Elena Faccenda;Adam J. Pawson

  • Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase

    Ann-Marie Conway;Soma Rakhit;Susan Pyne;Nigel J. Pyne

  • Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension

    Fiona Murray;Margaret R MacLean;Nigel J Pyne

  • Sphingosine 1-phosphate signalling in cancer

    Nigel J. Pyne;Francesca Tonelli;Keng Gat Lim;Jaclyn S. Long

  • Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.

    Susan Pyne;Sue Chin Lee;Jaclyn Long;Nigel J Pyne

  • Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.

    Susan Pyne;Joanna Chapman;Leslie Steele;Nigel J. Pyne

  • Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase Cδ, Lyn Kinase, and Matrix Metalloproteinases

    Yutong Zhao;Donghong He;Bahman Saatian;Tonya Watkins

  • FTY720 Analogues as Sphingosine Kinase 1 Inhibitors ENZYME INHIBITION KINETICS, ALLOSTERISM, PROTEASOMAL DEGRADATION, AND ACTIN REARRANGEMENT IN MCF-7 BREAST CANCER CELLS

    Keng Gat Lim;Francesca Tonelli;Zaiguo Li;Xuequan Lu

  • Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

    Nigel J. Pyne;Melissa McNaughton;Stephanie Boomkamp;Neil MacRitchie

  • Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.

    Soma Rakhit;Susan Pyne;Nigel J. Pyne

  • Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

    Catherine Waters;Balwinder Sambi;Kok Choi Kong;Dawn Thompson

  • Sphingosine 1-phosphate and cancer.

    Nigel J. Pyne;Ashref El Buri;David Roger Adams;Susan Pyne

Frequent Co-Authors

Susan Pyne
Susan Pyne University of Strathclyde
Miles D. Houslay
Miles D. Houslay King's College London
Robert Bittman
Robert Bittman City University of New York
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center
Viswanathan Natarajan
Viswanathan Natarajan University of Illinois at Chicago
Stuart M. Pitson
Stuart M. Pitson University of South Australia
Vadim Y. Arshavsky
Vadim Y. Arshavsky Duke University
Graeme Milligan
Graeme Milligan University of Glasgow
Peter R. Flatt
Peter R. Flatt University of Ulster
Michael J. O. Wakelam
Michael J. O. Wakelam Babraham Institute

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