World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
13885
World Ranking
7171
National Ranking
546

Nigel J. Pyne publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Nigel J. Pyne sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 231 publications — 61st percentile

61% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Nigel J. Pyne D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Nigel J. Pyne sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 70 D-Index — 65th percentile

65% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Nigel J. Pyne is affiliated with the University of Strathclyde in the United Kingdom and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology and cell biology, with significant work in immunology, physiology, and public health topics.

The main topics of their research include sphingolipid metabolism and signaling, lipid membrane structure and behavior, and endoplasmic reticulum stress and disease. They have also contributed to studies in acute lymphoblastic leukemia, immune cell function and interaction, erythrocyte function and pathophysiology, and enzyme function and inhibition.

Nigel J. Pyne has published in several well-known scientific journals. Frequent publication venues include:

  • British Journal of Pharmacology
  • Cellular Signalling
  • FEBS Letters
  • Nature Communications
  • Cells

Notable recent papers include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Enzymes, 2023, British Journal of Pharmacology
  • Recent advances in the role of sphingosine 1-phosphate in cancer, 2020, FEBS Letters
  • Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia, 2021, Nature Communications
  • Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1, 2020, Cells

The scientist collaborates frequently with several colleagues, including:

  • Susan Pyne
  • David R. Adams
  • Jeongah Oh
  • Federico Torta
  • S P H Alexander

Nigel J. Pyne's work notably spans enzyme research and lipid-related signaling pathways, with an emphasis on understanding cellular mechanisms related to disease processes such as cancer and leukemia. Their publication record includes contributions to comprehensive pharmacological guides alongside more specialized research articles.

Best Publications

  • Sphingosine 1-phosphate and cancer.

    Nigel J. Pyne;Susan Pyne

  • Sphingosine 1-phosphate signalling in mammalian cells

    Susan Pyne;Nigel J. Pyne

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

    Stephen P.H. Alexander;Doriano Fabbro;Eamonn Kelly;Alistair Mathie

  • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

    Francesca Tonelli;Keng Gat Lim;Carolyn Loveridge;Jaclyn Long

  • Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.

    Susan Pyne;Nigel Pyne

  • High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

    Carol Watson;Jaclyn S. Long;Clare Orange;Claire L. Tannahill

  • Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

    Forbes Alderton;Soma Rakhit;Kok Choi Kong;Timothy Palmer

  • Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

    Susan Pyne;David R. Adams;Nigel J. Pyne

  • The Concise Guide to PHARMACOLOGY 2013/14: overview

    Stephen P.H. Alexander;Helen E. Benson;Elena Faccenda;Adam J. Pawson

  • Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase

    Ann-Marie Conway;Soma Rakhit;Susan Pyne;Nigel J. Pyne

  • Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension

    Fiona Murray;Margaret R MacLean;Nigel J Pyne

  • Sphingosine 1-phosphate signalling in cancer

    Nigel J. Pyne;Francesca Tonelli;Keng Gat Lim;Jaclyn S. Long

  • Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.

    Susan Pyne;Sue Chin Lee;Jaclyn Long;Nigel J Pyne

  • Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.

    Susan Pyne;Joanna Chapman;Leslie Steele;Nigel J. Pyne

  • Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase Cδ, Lyn Kinase, and Matrix Metalloproteinases

    Yutong Zhao;Donghong He;Bahman Saatian;Tonya Watkins

  • FTY720 Analogues as Sphingosine Kinase 1 Inhibitors ENZYME INHIBITION KINETICS, ALLOSTERISM, PROTEASOMAL DEGRADATION, AND ACTIN REARRANGEMENT IN MCF-7 BREAST CANCER CELLS

    Keng Gat Lim;Francesca Tonelli;Zaiguo Li;Xuequan Lu

  • Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

    Nigel J. Pyne;Melissa McNaughton;Stephanie Boomkamp;Neil MacRitchie

  • Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.

    Soma Rakhit;Susan Pyne;Nigel J. Pyne

  • Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

    Catherine Waters;Balwinder Sambi;Kok Choi Kong;Dawn Thompson

  • Sphingosine 1-phosphate and cancer.

    Nigel J. Pyne;Ashref El Buri;David Roger Adams;Susan Pyne

Frequent Co-Authors

Susan Pyne
Susan Pyne University of Strathclyde
Miles D. Houslay
Miles D. Houslay King's College London
Robert Bittman
Robert Bittman City University of New York
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center
Viswanathan Natarajan
Viswanathan Natarajan University of Illinois at Chicago
Stuart M. Pitson
Stuart M. Pitson University of South Australia
Vadim Y. Arshavsky
Vadim Y. Arshavsky Duke University
Graeme Milligan
Graeme Milligan University of Glasgow
Peter R. Flatt
Peter R. Flatt University of Ulster
Michael J. O. Wakelam
Michael J. O. Wakelam Babraham Institute

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