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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
44397
World Ranking
758
National Ranking
42

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Graeme Milligan is affiliated with the University of Glasgow in the United Kingdom and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a particular focus on molecular biology and neuroscience. Their research spans multiple disciplines, including medicine, physiology, oncology, and materials chemistry. The scientist's work prominently addresses receptor mechanisms and signaling, neuropeptides and animal physiology, and drug transport and resistance mechanisms.

Their publication record includes influential papers exploring various aspects of receptor biology and signaling pathways. Notable recent papers include:

  • Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production (2020, Cell Reports)
  • Combinatorial expression of GPCR isoforms affects signalling and drug responses (2020, Nature)
  • Therapeutic Opportunities and Challenges in Targeting the Orphan G Protein-Coupled Receptor GPR35 (2020, ACS Pharmacology & Translational Science)
  • Metabolic and inflammatory functions of short-chain fatty acid receptors (2020, Current Opinion in Endocrine and Metabolic Research)
  • Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84 (2020, British Journal of Pharmacology)

Milligan frequently publishes in well-regarded scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Journal of Medicinal Chemistry
  • ACS Pharmacology & Translational Science
  • The Cambridge Structural Database

Their research addresses key topics such as receptor mechanisms and signaling, neuropeptides, animal physiology, adenosine and purinergic signaling, mass spectrometry techniques and applications, neuroscience and neuropharmacology research, and monoclonal and polyclonal antibodies research.

Collaborations form a significant aspect of Milligan's work. Frequent co-authors include Andrew B. Tobin, Laura Jenkins, Sara Marsango, Trond Ulven, and Brian D. Hudson, reflecting a network of partnerships that have contributed to advancing understanding in receptor biology and related signaling fields.

Milligan's scholarly contributions engage with the understanding of G protein-coupled receptors and their complex signaling behaviors, with particular attention to isoform-specific effects and therapeutic targeting of orphan receptors. This body of work spans basic molecular research to translational pharmacology.

Best Publications

  • Identification of a serotonin/glutamate receptor complex implicated in psychosis

    Javier González-Maeso;Rosalind L. Ang;Tony Yuen;Pokman Chan

  • Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers

    Francisco Ciruela;Vicent Casadó;Ricardo J. Rodrigues;Rafael Luján

  • Heterotrimeric G-proteins: a short history

    Graeme Milligan;Evi Kostenis

  • G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives

    Sergi Ferré;Vicent Casadó;Lakshmi A. Devi;Marta Filizola

  • Tailoring cAMP-signalling responses through isoform multiplicity

    Miles D. Houslay;Graeme Milligan

  • G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology

    Graeme Milligan

  • G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

    Evi Kostenis;Graeme Milligan;Arthur Christopoulos;Carlos F. Sanchez-Ferrer

  • The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State

    G. Enrico Rovati;Valérie Capra;Richard R. Neubig

  • Building a new conceptual framework for receptor heteromers

    Sergi Ferré;Ruben Baler;Michel Bouvier;Marc G. Caron

  • Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

    P Goldsmith;P Gierschik;G Milligan;C G Unson

  • The dynamic role of palmitoylation in signal transduction

    Graeme Milligan;Marco Parenti;Anthony I. Magee

  • The experimental power of FR900359 to study Gq-regulated biological processes

    Ramona Schrage;Anna Lena Schmitz;Evelyn Gaffal;Suvi Annala

  • Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer: THE HUMAN δ-OPIOID RECEPTOR DISPLAYS CONSTITUTIVE OLIGOMERIZATION AT THE CELL SURFACE, WHICH IS NOT REGULATED BY RECEPTOR OCCUPANCY *

    Mary McVey;Douglas Ramsay;Elaine Kellett;Stephen Rees

  • International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions

    Leigh A. Stoddart;Nicola J. Smith;Graeme Milligan

  • Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

    Graeme Milligan;Richard A. Bond;Melanie Lee

  • Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.

    F R McKenzie;G Milligan

  • G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function.

    Graeme Milligan

  • Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins

    G Milligan

  • Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective.

    Graeme Milligan

  • International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

    Jean Philippe Pin;Richard Neubig;Michel Bouvier;Lakshmi Devi

Frequent Co-Authors

Richard J. Ward
Richard J. Ward Universidade de São Paulo
Trond Ulven
Trond Ulven University of Copenhagen
Miles D. Houslay
Miles D. Houslay King's College London
Andrew B. Tobin
Andrew B. Tobin University of Glasgow
Evi Kostenis
Evi Kostenis University of Bonn
Stuart A. Nicklin
Stuart A. Nicklin University of Glasgow
Allen M. Spiegel
Allen M. Spiegel Albert Einstein College of Medicine
Andrew H. Baker
Andrew H. Baker University of Edinburgh
George S. Baillie
George S. Baillie University of Glasgow
Anthony I. Magee
Anthony I. Magee National Institutes of Health

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