His primary scientific interests are in Molecular biology, Cell biology, Biochemistry, Protein kinase A and Kinase. His Molecular biology research incorporates themes from Ca2+/calmodulin-dependent protein kinase, Mitogen-activated protein kinase kinase, SR protein, RNA polymerase II and MAP kinase kinase kinase. His studies in Cell biology integrate themes in fields like CREB, Caenorhabditis elegans and Alternative splicing.
His work deals with themes such as RNA splicing and RNA-binding protein, which intersect with Alternative splicing. His Casein kinase 2, Casein kinase 2, alpha 1 and Open reading frame study in the realm of Biochemistry connects with subjects such as Recoverin and Neurocalcin. The study incorporates disciplines such as CLK1, Calmodulin and Serine in addition to Kinase.
Masatoshi Hagiwara spends much of his time researching Molecular biology, Biochemistry, Cell biology, Kinase and Protein kinase A. His study looks at the relationship between Molecular biology and topics such as Ca2+/calmodulin-dependent protein kinase, which overlap with Calmodulin. His study in Cell biology is interdisciplinary in nature, drawing from both Regulation of gene expression, RNA splicing and Caenorhabditis elegans.
Alternative splicing is closely connected to RNA-binding protein in his research, which is encompassed under the umbrella topic of RNA splicing. As a part of the same scientific study, he usually deals with the Kinase, concentrating on Phosphorylation and frequently concerns with CREB. His Protein kinase A study frequently intersects with other fields, such as Myosin light-chain kinase.
His primary areas of investigation include Neuroscience, Cell biology, High-functioning autism, Spectrum disorder and RNA splicing. Masatoshi Hagiwara interconnects Astrocyte, Lung, Induced pluripotent stem cell, RNA-binding protein and Transcription in the investigation of issues within Cell biology. The various areas that Masatoshi Hagiwara examines in his RNA splicing study include Mutation, Molecular biology, Disease, Exon and Drug discovery.
The Molecular biology study which covers Gene knockdown that intersects with Intron. His biological study deals with issues like DNA, which deal with fields such as Alternative splicing. As a part of the same scientific family, Masatoshi Hagiwara mostly works in the field of Neurogenesis, focusing on Central nervous system and, on occasion, Kinase.
Masatoshi Hagiwara mainly focuses on Gene, Neurodevelopmental disorder, Transcriptome, Intron and Cancer research. His research on Gene often connects related topics like Cell biology. In his study, Induced pluripotent stem cell is strongly linked to Single-cell analysis, which falls under the umbrella field of Cell biology.
His Intron study integrates concerns from other disciplines, such as Frameshift mutation, RNA splicing, Gene knockdown and Incontinentia pigmenti. His Cancer research research includes elements of Immune checkpoint, Cancer cell, Ductal cells, Fatty acid and Regulation of gene expression. His research on Transcription also deals with topics like
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Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia;Roland P. S. Kwok;Ned Lamb;Masatoshi Hagiwara.
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.
Takashi Chijiwa;Atsushi Mishima;Masatoshi Hagiwara;Mamoru Sano.
Journal of Biological Chemistry (1990)
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II
Hiroshi Tokumitsu;Takashi Chijiwa;Masatoshi Hagiwara;Akihiro Mizutani.
Journal of Biological Chemistry (1990)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Daisuke Kaida;Hajime Motoyoshi;Etsu Tashiro;Takayuki Nojima.
Nature Chemical Biology (2007)
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB
Masatoshi Hagiwara;Arthur Alberts;Paul Brindle;Judy Meinkoth.
The newly synthesized selective Ca2+calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
Mariko Sumi;Kazutoshi Kiuchi;Tomohiko Ishikawa;Akira Ishii.
Biochemical and Biophysical Research Communications (1991)
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
Tetsuo Moriguchi;Noriyo Kuroyanagi;Kyoko Yamaguchi;Yukiko Gotoh.
Journal of Biological Chemistry (1996)
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A
M Hagiwara;P Brindle;A Harootunian;R Armstrong.
Molecular and Cellular Biology (1993)
Manipulation of Alternative Splicing by a Newly Developed Inhibitor of Clks
Michiko Muraki;Bisei Ohkawara;Takamitsu Hosoya;Hiroshi Onogi.
Journal of Biological Chemistry (2004)
A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo.
Yasuo Nagai;Masami Miyazaki;Ryoko Aoki;Takeru Zama.
Nature Biotechnology (2000)
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