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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
98
Citations
31084
World Ranking
577
National Ranking
43

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Hiroshi Kimura is affiliated with the Tokyo Institute of Technology in Japan and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology. Their research focuses primarily on Molecular Biology, with additional work in related subfields such as Plant Science, Physiology, Genetics, and Cell Biology.

The scientist's work spans multiple topics, with a significant emphasis on Genomics and Chromatin Dynamics, RNA Research and Splicing, Epigenetics and DNA Methylation, and RNA modifications and cancer. Other areas of research include Nuclear Structure and Function, Single-cell and spatial transcriptomics, and RNA and protein synthesis mechanisms.

Recent papers authored or co-authored by Hiroshi Kimura include:

  • Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner, 2020, eLife
  • Transcription organizes euchromatin via microphase separation, 2021, Nature Communications
  • Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells, 2020, Science Advances
  • POINT technology illuminates the processing of polymerase-associated intact nascent transcripts, 2021, Molecular Cell
  • Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence, 2020, Nature Communications

Hiroshi Kimura frequently collaborates with a number of researchers, including:

  • Yuko Sato
  • Yasuyuki Ohkawa
  • Tetsuya Handa
  • Hitoshi Kurumizaka
  • Timothy J. Stasevich

The scientist has published in various venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Genes to Cells
  • Journal of Cell Science
  • Cell Reports

The breadth of Hiroshi Kimura's work demonstrates a focus on understanding chromatin architecture and dynamics, transcriptional regulation, and RNA biology at the molecular level. Their research contributes to foundational knowledge in genome organization and gene expression mechanisms, particularly relevant to cell cycle processes and cellular senescence.

Best Publications

  • G-quadruplex structures mark human regulatory chromatin

    Robert Hänsel-Hertsch;Dario Beraldi;Stefanie V Lensing;Giovanni Marsico

  • Kinetics of Core Histones in Living Human Cells: Little Exchange of H3 and H4 and Some Rapid Exchange of H2b

    Hiroshi Kimura;Peter R. Cook

  • Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

    Toshiyuki Matsui;Danny Leung;Hiroki Miyashita;Irina A. Maksakova

  • Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing

    Takayuki Nojima;Tomás Gomes;Ana Rita Fialho Grosso;Hiroshi Kimura

  • H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells

    Krishanpal Karmodiya;Arnaud R Krebs;Arnaud R Krebs;Mustapha Oulad-Abdelghani;Hiroshi Kimura

  • Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

    Alexander E. Kelly;Cristina Ghenoiu;Cristina Ghenoiu;John Z. Xue;Christian Zierhut

  • Histone modifications for human epigenome analysis.

    Hiroshi Kimura

  • NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

    Tetsuro Hirose;Giorgio Virnicchi;Akie Tanigawa;Takao Naganuma

  • G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

    Makoto Tachibana;Yasuko Matsumura;Mikiko Fukuda;Hiroshi Kimura

  • Crystal structure of the human centromeric nucleosome containing CENP-A

    Hiroaki Tachiwana;Wataru Kagawa;Tatsuya Shiga;Akihisa Osakabe

  • DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

    Tsuyoshi Ikura;Satoshi Tashiro;Akemi Kakino;Hiroki Shima

  • The Organization of Histone H3 Modifications as Revealed by a Panel of Specific Monoclonal Antibodies

    Hiroshi Kimura;Hiroshi Kimura;Hiroshi Kimura;Yoko Hayashi-Takanaka;Yoko Hayashi-Takanaka;Yuji Goto;Yuji Goto;Nanako Takizawa

  • The functional organization of mitochondrial genomes in human cells

    Francisco J Iborra;Hiroshi Kimura;Peter R Cook

  • Alterations of lysine modifications on the histone H3 N-tail under drought stress conditions in Arabidopsis thaliana.

    Jong-Myong Kim;Taiko Kim To;Junko Ishida;Taeko Morosawa

  • Manipulation of Alternative Splicing by a Newly Developed Inhibitor of Clks

    Michiko Muraki;Bisei Ohkawara;Takamitsu Hosoya;Hiroshi Onogi

  • Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state

    Akira Kitamura;Hiroshi Kubota;Chan Gi Pack;Gen Matsumoto

  • U1 snRNA associates with TFIIH and regulates transcriptional initiation.

    Kon Yew Kwek;Shona Murphy;Andre Furger;Benjamin Thomas

  • Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs

    Emily Brookes;Inês de Santiago;Daniel Hebenstreit;Kelly J. Morris

  • Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore.

    Jan H Bergmann;Mariluz Gómez Rodríguez;Nuno M C Martins;Hiroshi Kimura

  • The transcription cycle of RNA polymerase II in living cells

    Hiroshi Kimura;Kimihiko Sugaya;Peter R. Cook

Frequent Co-Authors

Hitoshi Kurumizaka
Hitoshi Kurumizaka University of Tokyo
Yasuyuki Ohkawa
Yasuyuki Ohkawa Kyushu University
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Chikashi Obuse
Chikashi Obuse Osaka University
Makoto Tachibana
Makoto Tachibana Osaka University
Yasushi Hiraoka
Yasushi Hiraoka Osaka University
William C. Earnshaw
William C. Earnshaw University of Edinburgh
Peter R. Cook
Peter R. Cook University of Oxford
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo

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