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Chikashi Obuse

Chikashi Obuse

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
10441
World Ranking
18285
National Ranking
1314

Overview

Chikashi Obuse is affiliated with Osaka University in Japan and focuses on research within the domain of Biochemistry, Genetics, and Molecular Biology. They have contributed notably to several subfields including Molecular Biology, Genetics, Immunology, Cancer Research, and Rheumatology.

Their research covers a range of topics such as:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • CRISPR and Genetic Engineering
  • Genetics and Neurodevelopmental Disorders
  • RNA Research and Splicing
  • DNA Repair Mechanisms

Obuse has published extensively, with key papers including:

  • "Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy," 2020, Neurology
  • "Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing," 2020, Nature Protocols
  • "Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry," 2021, Nucleic Acids Research
  • "SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice," 2022, Development
  • "Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages," 2023, Nature Cell Biology

Frequent co-authors in Obuse's collaborative research include:

  • Koji Nagao
  • Tokuko Haraguchi
  • Yasushi Hiraoka
  • Hisashi Miura
  • Ichiro Hiratani

Their work is commonly found in publication venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Biochemistry
  • SSRN Electronic Journal
  • Neurology
  • Nature Protocols

Best Publications

  • Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

    Akiko Takahashi;Ryo Okada;Koji Nagao;Yuka Kawamata

  • Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

    Iraj Saadat;Hideaki Higashi;Chikashi Obuse;Mayumi Umeda

  • Regulation of DNA-replication origins during cell-cycle progression.

    Katsuhiko Shirahige;Yuji Hori;Katsuya Shiraishi;Minoru Yamashita

  • α-Klotho as a Regulator of Calcium Homeostasis

    Akihiro Imura;Yoshihito Tsuji;Miyahiko Murata;Ryota Maeda

  • Priming of Centromere for CENP-A Recruitment by Human hMis18α, hMis18β, and M18BP1

    Yohta Fujita;Yohta Fujita;Takeshi Hayashi;Tomomi Kiyomitsu;Yusuke Toyoda

  • Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

    Hideo Nishitani;Nozomi Sugimoto;Vassilis Roukos;Yohsuke Nakanishi

  • Human Blinkin/AF15q14 Is Required for Chromosome Alignment and the Mitotic Checkpoint through Direct Interaction with Bub1 and BubR1

    Tomomi Kiyomitsu;Chikashi Obuse;Mitsuhiro Yanagida

  • A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1

    Chikashi Obuse;Osamu Iwasaki;Tomomi Kiyomitsu;Gohta Goshima;Gohta Goshima

  • Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation

    Ryu-Suke Nozawa;Koji Nagao;Koji Nagao;Hiro-Taka Masuda;Osamu Iwasaki;Osamu Iwasaki

  • The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells

    Ryota Uehara;Ryu-suke Nozawa;Akiko Tomioka;Sabine Petry

  • Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

    Hiroshi Izuta;Masashi Ikeno;Nobutaka Suzuki;Takeshi Tomonaga

  • Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.

    Chikashi Obuse;Hua Yang;Naohito Nozaki;Shouhei Goto

  • Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.

    Ryu-Suke Nozawa;Koji Nagao;Ken-Taro Igami;Sachiko Shibata

  • BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation.

    Mayu Isono;Atsuko Niimi;Takahiro Oike;Yoshihiko Hagiwara

  • PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA

    Tetsuo Iida;Isao Suetake;Shoji Tajima;Hiroshi Morioka

  • The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

    Satoshi Abe;Kota Nagasaka;Youko Hirayama;Hiroko Kozuka-Hata

  • Active establishment of centromeric CENP-A chromatin by RSF complex

    Marinela Perpelescu;Naohito Nozaki;Chikashi Obuse;Hua Yang

  • The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

    Futoshi Suizu;Yosuke Hiramuki;Fumihiko Okumura;Mami Matsuda

  • The efficiency and timing of initiation of replication of multiple replicons of Saccharomyces cerevisiae chromosome VI

    Minoru Yamashita;Yuji Hori;Tomoyuki Shinomiya;Chikashi Obuse

  • The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1.

    Yasutoshi Tatsumi;Satoshi Ohta;Hiroshi Kimura;Toshiki Tsurimoto

Frequent Co-Authors

Yasushi Hiraoka
Yasushi Hiraoka Osaka University
Toshiki Tsurimoto
Toshiki Tsurimoto Kyushu University
Hiroshi Kimura
Hiroshi Kimura Tokyo Institute of Technology
Tokuko Haraguchi
Tokuko Haraguchi Osaka University
Mitsuhiro Yanagida
Mitsuhiro Yanagida Okinawa Institute of Science and Technology
Eiji Hara
Eiji Hara Osaka University
Masato T. Kanemaki
Masato T. Kanemaki National Institute of Genetics
Gohta Goshima
Gohta Goshima Nagoya University
Yasuyuki Ohkawa
Yasuyuki Ohkawa Kyushu University
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo

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