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Masanori Hatakeyama

Masanori Hatakeyama

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
20923
World Ranking
6225
National Ranking
402

Overview

Masanori Hatakeyama is affiliated with the University of Tokyo in Japan and conducts research primarily within the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work spans subfields including Molecular Biology, Surgery, Immunology, Cell Biology, and Pathology and Forensic Medicine.

The main topics that Masanori Hatakeyama focuses on include:

  • Helicobacter pylori-related gastroenterology studies
  • Galectins and Cancer Biology
  • Hippo pathway signaling and YAP/TAZ
  • Genetic factors in colorectal cancer
  • RNA Research and Splicing
  • Eosinophilic Esophagitis
  • Wnt/β-catenin signaling in development and cancer

The scientist has authored numerous papers, some of which are listed below with their year of publication and publication venues:

  • Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer, 2023, New England Journal of Medicine
  • Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis, 2021, Cell Host & Microbe
  • Helicobacter pylori-induced DNA double-stranded break in the development of gastric cancer, 2022, Cancer Science
  • Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells, 2020, Cancer Science
  • Non-Helicobacter pylori Gastric Microbiome Modulates Prooncogenic Responses and Is Associated With Gastric Cancer Risk, 2023, Gastro Hep Advances

Frequent collaborators on research projects include:

  • Takuya Ooki
  • Atsushi Takahashi-Kanemitsu
  • Takeru Hayashi
  • Naoko Murata-Kamiya
  • Christopher T. G. Knight

Publications by Masanori Hatakeyama appear most often in several venues, including:

  • Cancer Science (5 publications)
  • Biochemical and Biophysical Research Communications (2 publications)
  • International Journal of Molecular Sciences (2 publications)
  • New England Journal of Medicine (1 publication)
  • Cell Host & Microbe (1 publication)

Best Publications

  • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

    Shinichi Yachida;Sayaka Mizutani;Hirotsugu Shiroma;Satoshi Shiba

  • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

    Hideaki Higashi;Ryouhei Tsutsumi;Syuichi Muto;Toshiro Sugiyama

  • Oncogenic mechanisms of the Helicobacter pylori CagA protein

    Masanori Hatakeyama

  • Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

    Naomi Ohnishi;Hitomi Yuasa;Shinya Tanaka;Hirofumi Sawa

  • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

    Hideaki Higashi;Ryouhei Tsutsumi;Akiko Fujita;Shiho Yamazaki

  • Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

    N Murata-Kamiya;Y Kurashima;Y Teishikata;Y Yamahashi

  • Activation of β-catenin by carcinogenic Helicobacter pylori

    Aime T. Franco;Dawn A. Israel;Mary K. Washington;Uma Krishna

  • Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

    Iraj Saadat;Hideaki Higashi;Chikashi Obuse;Mayumi Umeda

  • Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis

    Masanori Hatakeyama

  • Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

    Mitsuo Maruyama;Hiroshi Shibuya;Hisashi Harada;Masanori Hatakeyama

  • Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase

    Ryouhei Tsutsumi;Hideaki Higashi;Megumi Higuchi;Masato Okada

  • Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

    Hideaki Higashi;Akihiro Nakaya;Ryouhei Tsutsumi;Kazuyuki Yokoyama

  • Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis.

    Masanori Hatakeyama;Hideaki Higashi

  • Association between Diversity in the Src Homology 2 Domain-Containing Tyrosine Phosphatase Binding Site of Helicobacter pylori CagA Protein and Gastric Atrophy and Cancer

    Takeshi Azuma;Shiho Yamazaki;Akiyo Yamakawa;Masahiro Ohtani

  • Helicobacter pylori and gastric carcinogenesis.

    Masanori Hatakeyama

  • Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

    Ryouhei Tsutsumi;Atsushi Takahashi;Takeshi Azuma;Hideaki Higashi

  • Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA

    Masanori Naito;Takeshi Yamazaki;Ryouhei Tsutsumi;Hideaki Higashi

  • Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells

    Hitoshi Tsugawa;Hidekazu Suzuki;Hideyuki Saya;Masanori Hatakeyama

  • Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein.

    Naoko Murata-Kamiya;Kenji Kikuchi;Kenji Kikuchi;Takeru Hayashi;Takeru Hayashi;Hideaki Higashi

  • Meta-analysis of the relationship between CagA seropositivity and gastric cancer.

    Takeshi Azuma;Masahiro Ohtani;Yukinao Yamazaki;Hideaki Higashi

Frequent Co-Authors

Takeshi Azuma
Takeshi Azuma Kobe University
Tadatsugu Taniguchi
Tadatsugu Taniguchi University of Tokyo
Hidekazu Suzuki
Hidekazu Suzuki Tokai University
Masayuki Miyasaka
Masayuki Miyasaka Osaka University
Toshiya Hirayama
Toshiya Hirayama Nagasaki University
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Shinya Tanaka
Shinya Tanaka Hokkaido University
Richard M. Peek
Richard M. Peek Vanderbilt University Medical Center
Yoshio Yamaoka
Yoshio Yamaoka Oita University
Toshifumi Hibi
Toshifumi Hibi Kitasato University

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