D-Index & Metrics Best Publications
Masanori Hatakeyama

Masanori Hatakeyama

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 54 Citations 12,283 124 World Ranking 7970 National Ranking 555

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Masanori Hatakeyama mainly investigates CagA, Helicobacter pylori, Tyrosine phosphorylation, Cancer research and Secretion. His CagA research is multidisciplinary, relying on both Kinase, Proto-oncogene tyrosine-protein kinase Src, Protein tyrosine phosphatase, Phosphorylation and Microbiology. Masanori Hatakeyama works mostly in the field of Phosphorylation, limiting it down to topics relating to Molecular biology and, in certain cases, Tyrosine.

His Microbiology study incorporates themes from Transport protein, Cell biology and Gene product. The study incorporates disciplines such as Cancer stem cell, Cancer, CD44 and Immunology in addition to Helicobacter pylori. His Cancer research research integrates issues from Signal transduction, Gastric mucosa and Transcription factor.

His most cited work include:

  • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. (879 citations)
  • Oncogenic mechanisms of the Helicobacter pylori CagA protein (588 citations)
  • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites (475 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in CagA, Helicobacter pylori, Molecular biology, Cancer research and Tyrosine phosphorylation. His CagA research is multidisciplinary, incorporating perspectives in Kinase, Protein tyrosine phosphatase, Phosphorylation, Carcinogenesis and Secretion. His research in Helicobacter pylori intersects with topics in Cancer, Virology, Immunology, Microbiology and Gastric mucosa.

His studies deal with areas such as Transactivation, Complementary DNA, Peptide sequence, Gene and Gene product as well as Molecular biology. His Cancer research research includes elements of Cell culture, Neoplastic transformation and STAT protein. His Tyrosine phosphorylation research incorporates elements of Phosphatase and Tight junction.

He most often published in these fields:

  • CagA (60.48%)
  • Helicobacter pylori (47.90%)
  • Molecular biology (34.73%)

What were the highlights of his more recent work (between 2013-2021)?

  • CagA (60.48%)
  • Helicobacter pylori (47.90%)
  • Cancer research (28.74%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in CagA, Helicobacter pylori, Cancer research, Secretion and Cancer. His CagA research incorporates themes from Tyrosine phosphorylation, Protein tyrosine phosphatase, Phosphorylation, Carcinogenesis and Molecular biology. Within one scientific family, Masanori Hatakeyama focuses on topics pertaining to Phosphatase under Tyrosine phosphorylation, and may sometimes address concerns connected to Wnt signaling pathway, Parafibromin and Tyrosine.

The Helicobacter pylori study combines topics in areas such as Virology, Microbiology, Gene, Gastric mucosa and Kinase. His work deals with themes such as Inflammation, Receptor, Gastric carcinogenesis and Neoplastic transformation, which intersect with Cancer research. His Secretion study combines topics from a wide range of disciplines, such as Heat shock protein, Heat shock, Phenotype, Antigen and Ectopic expression.

Between 2013 and 2021, his most popular works were:

  • Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis (228 citations)
  • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer (164 citations)
  • Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes. (120 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

Masanori Hatakeyama mainly focuses on Helicobacter pylori, CagA, Secretion, Cancer research and Carcinogenesis. Masanori Hatakeyama combines subjects such as Gene duplication, Molecular biology, Immunology and Gastric mucosa with his study of Helicobacter pylori. His biological study spans a wide range of topics, including Antigen and Virology.

Masanori Hatakeyama interconnects Inflammation, Tyrosine phosphorylation, Morphogen and Hedgehog, GLI1 in the investigation of issues within Cancer research. His Tyrosine phosphorylation research focuses on Phosphatase and how it connects with Protein tyrosine phosphatase. In the subject of general Carcinogenesis, his work in Neoplastic transformation is often linked to Fusobacterium nucleatum, thereby combining diverse domains of study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Hideaki Higashi;Ryouhei Tsutsumi;Syuichi Muto;Toshiro Sugiyama.
Science (2002)

1242 Citations

Oncogenic mechanisms of the Helicobacter pylori CagA protein

Masanori Hatakeyama.
Nature Reviews Cancer (2004)

918 Citations

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Hideaki Higashi;Ryouhei Tsutsumi;Akiko Fujita;Shiho Yamazaki.
Proceedings of the National Academy of Sciences of the United States of America (2002)

735 Citations

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

Naomi Ohnishi;Hitomi Yuasa;Shinya Tanaka;Hirofumi Sawa.
Proceedings of the National Academy of Sciences of the United States of America (2008)

698 Citations

Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

N Murata-Kamiya;Y Kurashima;Y Teishikata;Y Yamahashi.
Oncogene (2007)

521 Citations

Activation of β-catenin by carcinogenic Helicobacter pylori

Aime T. Franco;Dawn A. Israel;Mary K. Washington;Uma Krishna.
Proceedings of the National Academy of Sciences of the United States of America (2005)

511 Citations

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

Iraj Saadat;Hideaki Higashi;Chikashi Obuse;Mayumi Umeda.
Nature (2007)

481 Citations

Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase

Ryouhei Tsutsumi;Hideaki Higashi;Megumi Higuchi;Masato Okada.
Journal of Biological Chemistry (2003)

377 Citations

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

Hideaki Higashi;Akihiro Nakaya;Ryouhei Tsutsumi;Kazuyuki Yokoyama.
Journal of Biological Chemistry (2004)

347 Citations

Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis

Masanori Hatakeyama.
Cell Host & Microbe (2014)

343 Citations

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