Toshiya Hirayama

Overview

Best Publications

• β-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells

  Puja Vora;Adrienne Youdim;Lisa S. Thomas;Masayuki Fukata

  472
  Citations

• Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis.

  H Shirai;H Ito;T Hirayama;Y Nakamoto

  386
  Citations

• In vitro gene transfection using dendritic poly(L-lysine)

  Mio Ohsaki;Tatsuya Okuda;Akihiro Wada;Toshiya Hirayama

  366
  Citations

• Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori

  Akihiro Fujikawa;Daisuke Shirasaka;Daisuke Shirasaka;Shoichi Yamamoto;Hiroyoshi Ota

  320
  Citations

• MicroRNA signatures in Helicobacter pylori-infected gastric mucosa.

  Kayoko Matsushima;Hajime Isomoto;Naoki Inoue;Toshiyuki Nakayama

  251
  Citations

• Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells

  Hitoshi Tsugawa;Hidekazu Suzuki;Hideyuki Saya;Masanori Hatakeyama

  239
  Citations

• Binding of cationic α-helical peptides to plasmid DNA and their gene transfer abilities into cells

  Takuro Niidome;Naoya Ohmori;Akitoyo Ichinose;Akihiro Wada

  224
  Citations

• Activation of Helicobacter pylori VacA Toxin by Alkaline or Acid Conditions Increases Its Binding to a 250-kDa Receptor Protein-tyrosine Phosphatase β

  Kinnosuke Yahiro;Takuro Niidome;Miyuki Kimura;Tomomitsu Hatakeyama

  215
  Citations

• Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines.

  Volaluck Supajatura;Hiroko Ushio;Akihiro Wada;Kinnosuke Yahiro

  213
  Citations

• Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.

  Eiki Yamasaki;Eiki Yamasaki;Akihiro Wada;Akihiro Wada;Atsushi Kumatori;Ichiro Nakagawa

  211
  Citations

• Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to toll-like receptor 5 signaling in large intestinal epithelial cells

  Tsukasa Kawahara;Yuki Kuwano;Shigetada Teshima-Kondo;Ryu Takeya

  201
  Citations

• Salmonella enteritidis FliC (Flagella Filament Protein) Induces Human β-Defensin-2 mRNA Production by Caco-2 Cells *

  Ken Ichi Ogushi;Akihiro Wada;Takuro Niidome;Naoki Mori

  186
  Citations

• Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells

  Kazuyuki Yokoyama;Hideaki Higashi;Susumu Ishikawa;Yumiko Fujii

  184
  Citations

• Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor κB☆☆☆★

  Naoki Mori;Hiroshi Sato;Toshihisa Hayashibara;Masachika Senba

  174
  Citations

• ADP ribosylation of human neutrophil peptide-1 regulates its biological properties.

  Gregorino Paone;Akihiro Wada;Linda A. Stevens;Abul Matin

  171
  Citations

• Protein-tyrosine Phosphatase α, RPTPα, Is a Helicobacter pylori VacA Receptor

  Kinnosuke Yahiro;Akihiro Wada;Masaaki Nakayama;Takahiro Kimura

  156
  Citations

• Helicobacter pylori VacA-induced Inhibition of GSK3 through the PI3K/Akt Signaling Pathway

  Masaaki Nakayama;Junzo Hisatsune;Eiki Yamasaki;Hajime Isomoto

  145
  Citations

• Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells

  Miyuki Kimura;Shinji Goto;Akihiro Wada;Kinnosuke Yahiro

  132
  Citations

• Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pylori VacA

  Kinnosuke Yahiro;Mamoru Satoh;Masayuki Nakano;Junzo Hisatsune;Junzo Hisatsune

  131
  Citations

• Peptide antibiotic human beta‐defensin‐1 and −2 contribute to antimicrobial defense of the intrahepatic biliary tree

  Kenichi Harada;Kazuo Ohba;Satoru Ozaki;Kumiko Isse

  127
  Citations