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D-Index & Metrics

Microbiology

D-Index
65
Citations
18236
World Ranking
2483
National Ranking
185

Overview

Jan Wehkamp is affiliated with the University of Tübingen in Germany and specializes in the fields of Medicine and Immunology and Microbiology. Their research output includes significant contributions to microbiology, molecular biology, nutrition and dietetics, genetics, and epidemiology.

The scientist's work focuses primarily on topics such as antimicrobial peptides and activities, gut microbiota and health, inflammatory bowel disease, pediatric health and respiratory diseases, infant nutrition and health, probiotics and fermented foods, and microscopic colitis.

Frequent co-authors in Jan Wehkamp's research include Benjamin A. H. Jensen, Amy Hart, Esi Lamousé-Smith, Jean-Frédéric Colombel, and Peter Nordkild. These collaborations indicate an active engagement in multidisciplinary studies.

Their publications appear in several prominent journals, with the majority published in Gastroenterology, followed by Frontiers in Immunology, Zeitschrift für Gastroenterologie, Gut, and Nature. This distribution reflects a consistent contribution to high-impact venues in the fields of gastroenterology and immunology.

  • "An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease", 2020, Frontiers in Immunology
  • "Biopsy and blood-based molecular biomarker of inflammation in IBD", 2022, Gut
  • "Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis", 2020, Frontiers in Immunology
  • "Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis", 2020, Gastroenterology
  • "Using Computer Vision to Improve Endoscopic Disease Quantification in Therapeutic Clinical Trials of Ulcerative Colitis", 2023, Gastroenterology

The research by Jan Wehkamp addresses chronic inflammatory conditions of the gut, particularly Crohn's disease and ulcerative colitis, exploring immune modulation and molecular biomarkers. The interplay between nutrition, gut microbiota, and inflammation is another key area they investigate.

Best Publications

  • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

    Wolfgang Hueber;Bruce E Sands;Steve Lewitzky;Marc Vandemeulebroecke

  • Reduced Paneth cell α-defensins in ileal Crohn's disease

    Jan Wehkamp;Nita H. Salzman;Edith Porter;Edith Porter;Sabine Nuding

  • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression.

    J. Wehkamp;J. Harder;M. Weichenthal;M. Schwab

  • A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

    Klaus Fellermann;Daniel E. Stange;Elke Schaeffeler;Hartmut Schmalzl

  • NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by Escherichia coli Nissle 1917: a Novel Effect of a Probiotic Bacterium

    Jan Wehkamp;Jürgen Harder;Kai Wehkamp;Birte Wehkamp-von Meissner

  • Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

    Bjoern O. Schroeder;Zhihong Wu;Sabine Nuding;Sabine Nuding;Sandra Groscurth

  • Intestinal barrier in inflammatory bowel disease.

    Lena Antoni;Sabine Nuding;Jan Wehkamp;Eduard F Stange

  • Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2

    M Schlee;J Harder;B Köten;E F Stange

  • Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

    Hiutung Chu;Marzena Pazgier;Grace Jung;Sean Paul Nuccio

  • Inducible and constitutive β‐defensins are differentially expressed in Crohn's disease and ulcerative colitis

    Jan Wehkamp;Juergen Harder;Michael Weichenthal;Oliver Mueller

  • NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.

    Eske Voss;Jan Wehkamp;Kai Wehkamp;Eduard F. Stange

  • Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin

    Miriam Schlee;Jan Wehkamp;Jan Wehkamp;Artur Altenhoefer;Tobias A. Oelschlaeger

  • Antimicrobial peptides and gut microbiota in homeostasis and pathology

    Maureen J. Ostaff;Eduard Friedrich Stange;Jan Wehkamp

  • The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-4

    Jan Wehkamp;Guoxing Wang;Irmgard Kübler;Sabine Nuding

  • Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.

    Michael Gersemann;Svetlana Becker;Svetlana Becker;Irmgard Kübler;Maureen Koslowski

  • Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.

    Zora Teltschik;Reiner Wiest;Julia Beisner;Sabine Nuding

  • Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

    Laurent Peyrin-Biroulet;Julia Beisner;Guoxing Wang;Sabine Nuding;Sabine Nuding

  • Reduced mucosal antimicrobial activity in Crohn’s disease of the colon

    Sabine Nuding;Klaus Fellermann;Jan Wehkamp;Eduard F Stange

  • Crohn's disease: a defensin deficiency syndrome?

    Klaus Fellermann;Jan Wehkamp;Klaus R Herrlinger;Eduard F Stange

  • Defensins and other antimicrobial peptides in inflammatory bowel disease.

    Jan Wehkamp;Michael Schmid;Eduard F Stange

  • Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.

    Jan Wehkamp;Michael Schmid;Klaus Fellermann;Eduard F. Stange

Frequent Co-Authors

Eduard F. Stange
Eduard F. Stange Robert Bosch Hospital
Matthias Schwab
Matthias Schwab University of Tübingen
Charles L. Bevins
Charles L. Bevins University of California, Davis
Martin Schaller
Martin Schaller University of Tübingen
Walter Reinisch
Walter Reinisch Medical University of Vienna
Jürgen Harder
Jürgen Harder Kiel University
Derek P. Jewell
Derek P. Jewell University of Oxford
Tomas Ganz
Tomas Ganz University of California, Los Angeles
Manolis Pasparakis
Manolis Pasparakis University of Cologne

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