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2025

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  • 2025 - Research.com Best Scientists Award

Overview

Jean-Frederic Colombel is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research focuses primarily on inflammatory bowel disease (IBD) and related gastrointestinal disorders. With a substantial body of work, they have contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology.

Colombel's research encompasses several subfields including genetics, epidemiology, surgery, immunology, and infectious diseases. Their main topics of work are:

  • Inflammatory Bowel Disease
  • Microscopic Colitis
  • Immunodeficiency and Autoimmune Disorders
  • Eosinophilic Esophagitis
  • Autoimmune and Inflammatory Disorders
  • SARS-CoV-2 and COVID-19 Research
  • Diverticular Disease and Complications

Some of their most notable recent papers include:

  • STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD, 2021, Gastroenterology
  • Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry, 2020, Gastroenterology
  • Upadacitinib Induction and Maintenance Therapy for Crohn's Disease, 2023, New England Journal of Medicine
  • Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn's Disease, 2020, Gastroenterology
  • The intestinal barrier, an arbitrator turned provocateur in IBD, 2020, Nature Reviews Gastroenterology & Hepatology

Colombel frequently collaborates with a number of coauthors, among whom are:

  • Ryan C. Ungaro
  • Manasi Agrawal
  • Silvio Danese
  • Marla C. Dubinsky
  • Bruce E. Sands

Their work is widely published in key venues related to gastroenterology and inflammatory diseases, including:

  • Gastroenterology
  • Journal of Crohn's and Colitis
  • The American Journal of Gastroenterology
  • Clinical Gastroenterology and Hepatology
  • Inflammatory Bowel Diseases

Best Publications

  • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

    Jean-Pierre Hugot;Mathias Chamaillard;Mathias Chamaillard;Habib Zouali;Suzanne Lesage

  • Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

    Stephen B Hanauer;Brian G Feagan;Gary R Lichtenstein;Lloyd F Mayer

  • Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

    Mark S. Silverberg;Jack Satsangi;Tariq Ahmad;Ian D. R. Arnott

  • Infliximab for induction and maintenance therapy for ulcerative colitis.

    Paul Rutgeerts;William J Sandborn;Brian G Feagan;Walter Reinisch

  • Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

    Jean Frédéric Colombel;William J. Sandborn;Walter Reinisch;Gerassimos J. Mantzaris

  • Vedolizumab as induction and maintenance therapy for ulcerative colitis.

    Brian G Feagan;Paul Rutgeerts;Bruce E Sands;Stephen Hanauer

  • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial.

    Jean–Frédéric Colombel;William J. Sandborn;Paul Rutgeerts;Robert Enns

  • Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

    William J. Sandborn;Brian G. Feagan;Paul Rutgeerts;Stephen Hanauer

  • Crohn's disease

    Joana Torres;Saurabh Mehandru;Jean-Frédéric Colombel;Laurent Peyrin-Biroulet

  • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

    Arlette Darfeuille-Michaud;Jérôme Boudeau;Philippe Bulois;Christel Neut

  • Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.

    L. Peyrin-Biroulet;W. Sandborn;B. E. Sands;W. Reinisch;W. Reinisch

  • The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management

    A. Dignass;G. Van Assche;J.O. Lindsay;M. Lémann

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Carl A. Anderson;Gabrielle Boucher;Charlie W. Lees;Andre Franke

  • Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD

    Marco Daperno;Geert D'Haens;Gert Van Assche;Filip Baert

  • STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

    Dan Turner;Amanda Ricciuto;Ayanna Lewis;Ferdinando D’Amico

  • Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management

    Axel Dignass;James O. Lindsay;Andreas Sturm;Alastair Windsor

  • Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis

    William J. Sandborn;Gert van Assche;Walter Reinisch;Jean–Frederic Colombel

  • Mapping of a susceptibility locus for Crohn's disease on chromosome 16

    J P Hugot;P Laurent-Puig;C Gower-Rousseau;J M Olson

  • Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

    Laurent Beaugerie;Nicole Brousse;Anne Marie Bouvier;Jean Frédéric Colombel

  • Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial.

    William J. Sandborn;Paul Rutgeerts;Robert Enns;Stephen B. Hanauer

Frequent Co-Authors

William J. Sandborn
William J. Sandborn University of California, San Diego
Walter Reinisch
Walter Reinisch Medical University of Vienna
Bruce E. Sands
Bruce E. Sands Icahn School of Medicine at Mount Sinai
Brian G. Feagan
Brian G. Feagan University of Western Ontario
Laurent Peyrin-Biroulet
Laurent Peyrin-Biroulet University of Lorraine
Edward V. Loftus
Edward V. Loftus Mayo Clinic
Geert R. D'Haens
Geert R. D'Haens University of Amsterdam
Remo Panaccione
Remo Panaccione University of Calgary
Marc Lémann
Marc Lémann Université Paris Cité

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