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Medicine

D-Index
126
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59858
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2954
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158

Research.com Recognitions

  • 2014 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Physiology and Pharmacology/Toxicology
  • 1994 - Member of Academia Europaea

Overview

Matthias Schwab is affiliated with the University of Tübingen in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields including Oncology, Molecular Biology, Pharmacology, Pediatrics, Perinatology and Child Health, and Genetics.

The main topics covered in Schwab's scientific work include:

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Pharmaceutical Studies and Practices
  • Estrogen and Related Hormone Effects
  • Cancer Genomics and Diagnostics
  • Renal Cell Carcinoma Treatment
  • Multiple Sclerosis Research Studies

Frequent coauthors collaborating with Schwab are:

  • Elke Schaeffeler (61 collaborations)
  • Ute Hofmann (31 collaborations)
  • Thomas E. Mürdter (30 collaborations)
  • Stefan Winter (29 collaborations)
  • Roman Tremmel (25 collaborations)

Common publication venues for Schwab's work include:

  • Clinical Pharmacology & Therapeutics (16 publications)
  • Cancer Research (8 publications)
  • CPT Pharmacometrics & Systems Pharmacology (7 publications)
  • Pharmaceutics (7 publications)
  • Cells (7 publications)

Recent papers by Matthias Schwab include:

  • "A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study" (2023, The Lancet)
  • "Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing" (2020, Clinical Pharmacology & Therapeutics)
  • "The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets" (2021, Cancer Discovery)
  • "Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial" (2022, The Lancet Infectious Diseases)
  • "Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy" (2020, Genome Medicine)

The scientist has also contributed to book publications with Springer Science+Business Media, including:

  • "Pediatric Pharmacotherapy" (2020)
  • "Precision Medicine" (2023)

Matthias Schwab's research is connected to awards such as membership in the German National Academy of Sciences Leopoldina since 2014, with a focus on Physiology and Pharmacology/Toxicology, and membership in Academia Europaea since 1994.

Best Publications

  • Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

    Ulrich M. Zanger;Matthias Schwab;Matthias Schwab

  • Metformin improves healthspan and lifespan in mice

    Alejandro Martin-Montalvo;Evi M. Mercken;Sarah J. Mitchell;Sarah J. Mitchell;Sarah J. Mitchell;Hector H. Palacios

  • Reduced Paneth cell α-defensins in ileal Crohn's disease

    Jan Wehkamp;Nita H. Salzman;Edith Porter;Edith Porter;Sabine Nuding

  • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression.

    J. Wehkamp;J. Harder;M. Weichenthal;M. Schwab

  • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

    Ingolf Cascorbi;Thomas Gerloff;Andreas Johne;Christian Meisel

  • Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update

    M V Relling;E E Gardner;W J Sandborn;K Schmiegelow

  • A New Molecular Predictor of Distant Recurrence in ER-Positive, HER2-Negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors

    Martin Filipits;Margaretha Rudas;Raimund Jakesz;Peter Dubsky

  • Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

    Ulrich M. Zanger;Ulrich M. Zanger;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Kathrin Klein;Kathrin Klein;Matthias Schwab;Matthias Schwab

  • A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

    Klaus Fellermann;Daniel E. Stange;Elke Schaeffeler;Hartmut Schmalzl

  • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

    Thomas Lang;Kathrin Klein;Joachim Fischer;Andreas K. Nüssler

  • Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen

    Werner Schroth;Matthew P. Goetz;Ute Hamann;Peter A. Fasching;Peter A. Fasching

  • Sex is a major determinant of CYP3A4 expression in human liver

    Renzo Wolbold;Kathrin Klein;Oliver Burk;Andreas K. Nüssler

  • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.

    Werner Schroth;Lydia Antoniadou;Peter Fritz;Matthias Schwab

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

    Ursula Amstutz;Linda M. Henricks;Steven M. Offer;Julia Barbarino

  • Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

    Mary V. Relling;Matthias Schwab;Matthias Schwab;Michelle Whirl-Carrillo;Guilherme Suarez-Kurtz

  • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

    Elke Schaeffeler;Christine Fischer;Dierk Brockmeier;Dorothee Wernet

  • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

    Mikko Niemi;Elke Schaeffeler;Thomas Lang;Martin F Fromm

  • The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells.

    Monika Hitzl;Siegfried Drescher;Heiko Van Der Kuip;Elke Schäffeler

  • Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

    Matthias Schwab;Ulrich M. Zanger;Claudia Marx;Elke Schaeffeler

  • NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

    Takaya Moriyama;Takaya Moriyama;Rina Nishii;Rina Nishii;Virginia Perez-Andreu;Wenjian Yang

Frequent Co-Authors

Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Ute Hofmann
Ute Hofmann University of Tübingen
Ulrich M. Zanger
Ulrich M. Zanger Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Kathrin Klein
Kathrin Klein Robert Bosch (Germany)
Eduard F. Stange
Eduard F. Stange Robert Bosch Hospital
Jan Wehkamp
Jan Wehkamp University of Tübingen
Otto W. Witte
Otto W. Witte Friedrich Schiller University Jena
Meinrad Gawaz
Meinrad Gawaz University of Tübingen
Ulrich Klotz
Ulrich Klotz Robert Bosch (Germany)

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