World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
87
Citations
28557
World Ranking
13621
National Ranking
520

Research.com Recognitions

  • 2020 - Member of Academia Europaea

Overview

Henk-Jan Guchelaar is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the field of Medicine, with a particular focus on Pharmacology, Oncology, Pediatrics, Perinatology and Child Health, Molecular Biology, and Pulmonary and Respiratory Medicine. These specialized domains reflect the scientist's diverse expertise in biomedical sciences and clinical research.

Their scholarly output emphasizes several main topics, including Pharmacogenetics and Drug Metabolism, Pharmaceutical Studies and Practices, Colorectal Cancer Treatments and Studies, Neutropenia and Cancer Infections, Cancer Treatment and Pharmacology, Statistical Methods in Clinical Trials, and Inflammatory Mediators and NSAID Effects. This range of research topics illustrates a concentration on pharmacological interventions and cancer-related studies alongside methodologies for clinical trial analysis.

Henk-Jan Guchelaar has contributed to numerous scientific articles published across a variety of journals. Frequent publication venues include Clinical Pharmacology & Therapeutics, European Journal of Human Genetics, Frontiers in Pharmacology, British Journal of Clinical Pharmacology, and Annals of Oncology. These journals are notable for disseminating research in clinical pharmacology, genetics, oncology, and broader pharmacological sciences.

Their recent papers demonstrate active involvement in pharmacogenetics and clinical implementation studies. Selected recent publications are:

  • A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study (2023, The Lancet)
  • Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review (2020, Journal of Clinical Medicine)
  • Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics (2023, European Journal of Human Genetics)
  • Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs (2021, European Journal of Human Genetics)
  • Individualized Dosing of Fluoropyrimidine-Based Chemotherapy to Prevent Severe Fluoropyrimidine-Related Toxicity: What Are the Options? (2020, Clinical Pharmacology & Therapeutics)

Collaboration appears integral to their research, with frequent co-authors including Jesse J. Swen, Hans Gelderblom, Ron H.J. Mathijssen, Ron H. N. van Schaik, and Dirk Jan A. R. Moes. These collaborators have each contributed significantly to shared scientific output, suggesting sustained and productive research partnerships.

Recognition of Henk-Jan Guchelaar's contributions includes the award of Membership in Academia Europaea in 2020, underscoring a level of acknowledgement within the broader European scientific community.

Best Publications

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Pharmacogenetics: from bench to byte--an update of guidelines.

    J.J. Swen;M. Nijenhuis;A. De Boer;L. Grandia

  • Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions.

    A. Vermes;H.-J. Guchelaar;J. Dankert

  • The Risk of Cancer in Users of Statins

    Matthijs R. Graaf;Annette B. Beiderbeck;Antoine C.G. Egberts;Dick J. Richel

  • Cardiotoxicity of cytotoxic drugs.

    Kirsten J.M Schimmel;Dick J Richel;Renée B.A van den Brink;Henk-Jan Guchelaar

  • Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.

    Kelly E. Caudle;Katrin Sangkuhl;Michelle Whirl‐Carrillo;Jesse J. Swen

  • Clinical pharmacokinetics of tyrosine kinase inhibitors.

    Nielka P. van Erp;Hans Gelderblom;Henk-Jan Guchelaar

  • Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis

    J. A. M. Wessels;T. W. J. Huizinga;H.-J. Guchelaar

  • Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

    Matthijs R. Graaf;Dick J. Richel;Cornelis J.F. van Noorden;Henk-Jan Guchelaar

  • DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

    Linda M. Henricks;Carin A.T.C. Lunenburg;Femke M. de Man;Didier Meulendijks

  • Liposomal drug formulations in cancer therapy: 15 years along the road.

    Marije Slingerland;Henk-Jan Guchelaar;Hans Gelderblom

  • Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

    C. H. van der Wouden;A. Cambon-Thomsen;E. Cecchin;K. C. Cheung

  • Making sense of big data in health research: Towards an EU action plan

    Charles Auffray;Charles Auffray;Rudi Balling;Inês Barroso;László Bencze

  • A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis.

    Judith A. M. Wessels;Sjoerd M. van der Kooij;Saskia le Cessie;Wietske Kievit

  • Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes

    Judith A. M. Wessels;Jeska K. de Vries-Bouwstra;Bas T. Heijmans;P. Eline Slagboom

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.

    Matthew P. Goetz;Katrin Sangkuhl;Henk Jan Guchelaar;Matthias Schwab

  • Pharmacogenetics: From Bench to Byte

    J.J. Swen;I. Wilting;AL De Goede;L. Grandia

  • Translating pharmacogenomics : Challenges on the road to the clinic

    Jesse J. Swen;Tom W J Huizinga;Hans Gelderblom;Elisabeth G E de Vries

  • Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity

    Nielka P. van Erp;Karel Eechoute;Astrid A. van der Veldt;John B. Haanen

  • Radiation-induced Xerostomia: Pathophysiology, Clinical Course and Supportive Treatment

    Guchelaar Hj;Vermes A;Meerwaldt Jh

Frequent Co-Authors

Hans Gelderblom
Hans Gelderblom Leiden University Medical Center
Jan H.M. Schellens
Jan H.M. Schellens Utrecht University
Tom W. J. Huizinga
Tom W. J. Huizinga Leiden University Medical Center
Ron H.J. Mathijssen
Ron H.J. Mathijssen Erasmus University Rotterdam
Hein Putter
Hein Putter Leiden University Medical Center
Cornelis J. A. Punt
Cornelis J. A. Punt University of Amsterdam
Jos H. Beijnen
Jos H. Beijnen Utrecht University
J.H. Frederik Falkenburg
J.H. Frederik Falkenburg Leiden University Medical Center
Ron H.N. van Schaik
Ron H.N. van Schaik Erasmus University Rotterdam
Cristina Rodríguez-Antona
Cristina Rodríguez-Antona Alberto Sols Biomedical Research Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a career in medicine doesn't always mean becoming a doctor. There are many alternative healthcare degrees online that offer rewarding career paths and greater flexibility. From clinical roles to administrative specialties, students can find affordable programs that fit various interests and budgets.

For those interested in healthcare administration, exploring the medical billing and coding cost can help you understand the investment required to start in this growing field. If you're aiming for advanced clinical practice, there are cheapest np programs online that allow nurses to qualify as nurse practitioners at a lower cost.

Entry-level nursing remains highly accessible as well, with plenty of affordable nursing programs online for both aspiring and current nurses. For those looking to advance into leadership or academic positions, you can explore the cheapest dnp programs online which offer a route to a doctoral degree in nursing without a huge financial burden.

Whether you’re just starting or seeking to advance your healthcare career, these online degree options open doors to new opportunities and provide cost-effective alternatives to traditional medical school.

Best Scientists Citing Henk-Jan Guchelaar

Trending Scientists