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Kazuhiko Yamamoto

Kazuhiko Yamamoto

D-Index & Metrics

Immunology

D-Index
108
Citations
48912
World Ranking
531
National Ranking
17

Medicine

D-Index
110
Citations
50055
World Ranking
5515
National Ranking
119

Research.com Recognitions

  • 1996 - Fellow of the International Association for Pattern Recognition (IAPR) For contributions to character recognition and for service to IAPR

Overview

Kazuhiko Yamamoto is a researcher affiliated with RIKEN in Japan, specializing broadly in medicine with a focus on immunology and molecular biology. Their work spans several interconnected subfields, including immunology, molecular biology, rheumatology, genetics, and pathology. The scientist's research topics encompass immune cell function and interaction, systemic lupus erythematosus, T-cell and B-cell immunology, rheumatoid arthritis research and therapies, monoclonal and polyclonal antibodies, lymphoma diagnosis and treatment, and genetic associations and epidemiology.

Yamamoto's publication record includes contributions to various scientific outlets, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of the Rheumatic Diseases
  • Journal of Autoimmunity
  • Nature Genetics
  • Modern Rheumatology

Among their recent papers are:

  • "A cross-population atlas of genetic associations for 220 human phenotypes," 2021, Nature Genetics
  • "Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases," 2020, Nature Genetics
  • "Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases," 2021, Cell
  • "Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis," 2022, Nature Genetics
  • "Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus," 2020, Annals of the Rheumatic Diseases

The scientist has collaborated frequently with several colleagues, including:

  • Keishi Fujio
  • Kazuyoshi Ishigaki
  • Akari Suzuki
  • Mineto Ota
  • Yasuo Nagafuchi

In the course of their career, they have received recognition such as being named a Fellow of the International Association for Pattern Recognition (IAPR) in 1996, cited for contributions to character recognition and service to IAPR.

Best Publications

  • Rheumatoid arthritis

    Unknown

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • A cross-population atlas of genetic associations for 220 human phenotypes

    Saori Sakaue;Masahiro Kanai;Yosuke Tanigawa;Juha Karjalainen

  • Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.

    Akari Suzuki;Ryo Yamada;Xiaotian Chang;Shinya Tokuhiro

  • Treatment of rheumatoid arthritis with humanized anti–interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial

    Norihiro Nishimoto;Kazuyuki Yoshizaki;Nobuyuki Miyasaka;Kazuhiko Yamamoto

  • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab

    Norihiro Nishimoto;Jun Hashimoto;Nobuyuki Miyasaka;Kazuhiko Yamamoto

  • An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.

    Shinya Tokuhiro;Ryo Yamada;Xiaotian Chang;Akari Suzuki

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Cristian Pattaro;Alexander Teumer;Mathias Gorski;Audrey Y. Chu

  • Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

    Kazuyoshi Ishigaki;Kazuyoshi Ishigaki;Masato Akiyama;Masahiro Kanai;Masahiro Kanai;Atsushi Takahashi

  • Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.

    Yoichiro Iwakura;Mariko Tosu;Emi Yoshida;Masafumi Takiguchi

  • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy

    Norihiro Nishimoto;Nobuyuki Miyasaka;Kazuhiko Yamamoto;Shinichi Kawai

  • A functional variant in FCRL3 , encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

    Yuta Kochi;Ryo Yamada;Akari Suzuki;John B. Harley;John B. Harley;John B. Harley

  • Expression and Function of Toll-Like Receptors in Eosinophils: Activation by Toll-Like Receptor 7 Ligand

    Hiroyuki Nagase;Shu Okugawa;Yasuo Ota;Masao Yamaguchi

  • Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

    Norihiro Nishimoto;Nobuyuki Miyasaka;Kazuhiko Yamamoto;Shinichi Kawai

  • An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor

    Maho Suzukawa;Motoyasu Iikura;Rikiya Koketsu;Hiroyuki Nagase

  • Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

    Yukinori Okada;Chikashi Terao;Katsunori Ikari;Yuta Kochi

  • Generation of CD4+CD25+ regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

    Kimito Kawahata;Yoshikata Misaki;Michiko Yamauchi;Shinji Tsunekawa

  • Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells

    Takashi Sekiya;Misato Miyamasu;Masako Imanishi;Hirokazu Yamada

  • A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.

    Yuta Kochi;Yukinori Okada;Akari Suzuki;Katsunori Ikari

  • Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

    Y. Okada;X. Sim;X. Sim;M. J. Go;J. Y. Wu;J. Y. Wu

  • Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice

    Shin Kawasaki;Hajime Takizawa;Hiroyuki Yoneyama;Takashi Nakayama

  • Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes.

    Toshihiro Nakajima;Hiroyuki Aono;Tomoko Hasunuma;Kazuhiko Yamamoto

Frequent Co-Authors

Keishi Fujio
Keishi Fujio University of Tokyo
Ryo Yamada
Ryo Yamada Kyoto University
Yukinori Okada
Yukinori Okada Osaka University
Hisashi Yamanaka
Hisashi Yamanaka International University of Health and Welfare
Koichi Hirai
Koichi Hirai University of Tokyo
Yoshiya Tanaka
Yoshiya Tanaka University of Occupational and Environmental Health Japan
Tsutomu Takeuchi
Tsutomu Takeuchi Keio University
Yusuke Nakamura
Yusuke Nakamura National Institutes of Biomedical Innovation, Health and Nutrition
Nobuyuki Miyasaka
Nobuyuki Miyasaka Tokyo Medical and Dental University

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