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Immunology

D-Index
66
Citations
14850
World Ranking
2768
National Ranking
104

Overview

J.H. Frederik Falkenburg is affiliated with Leiden University Medical Center in the Netherlands and conducts research primarily in the fields of Immunology and Microbiology as well as Medicine. Their scientific work encompasses a range of topics related to immune system function and therapeutic interventions.

The main areas of study in Falkenburg's research include:

  • Immunology and Microbiology
  • Medicine

Falkenburg's research covers subfields such as Immunology, Oncology, Hematology, Molecular Biology, and Genetics. The specific scientific topics addressed in their work are diverse and focus largely on immune system interactions, therapeutic strategies, and disease mechanisms. These include:

  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Hematopoietic Stem Cell Transplantation
  • Vaccines and immunoinformatics approaches
  • Virus-based gene therapy research

Among the recent papers authored by Falkenburg are notable studies including:

  • Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM, published in 2020 in Blood
  • Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure, published in 2022 in OncoImmunology
  • HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study, published in 2020 in Frontiers in Immunology
  • Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies, published in 2020 in The Journal of Immunology
  • Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals, published in 2022 in Frontiers in Immunology

Falkenburg frequently publishes in various scientific journals, including:

  • Frontiers in Immunology
  • Blood
  • Journal for ImmunoTherapy of Cancer
  • The Journal of Immunology
  • Molecular Therapy - Oncolytics

The scientist has collaborated extensively with a number of frequent co-authors such as Mirjam H.M. Heemskerk, Dennis F.G. Remst, Michel G.D. Kester, Anne K. Wouters, and Renate S. Hagedoorn, illustrating a collaborative research network focused on immunological and hematological studies.

Best Publications

  • Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34+ cells in NOD/SCID mice

    Willy A Noort;Alwine B Kruisselbrink;Pieternella S in't Anker;Marjolein Kruger

  • Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.

    W. A. Erik Marijt;Mirjam H. M. Heemskerk;Freke M. Kloosterboer;Els Goulmy

  • Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells

    A. A. A. M. Danen-Van Oorschot;D. F. Fischer;J. M. Grimbergen;B. Klein

  • Allo-HLA reactivity of virus-specific memory T cells is common.

    Avital L. Amir;Lloyd J. A. D'Orsogna;Dave L. Roelen;Marleen M. van Loenen

  • Complete remission of accelerated phase chronic myeloid leukemia by treatment with leukemia-reactive cytotoxic T lymphocytes.

    J.H. Frederik Falkenburg;Amon R. Wafelman;Peter Joosten;Willem M. Smit

  • Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region.

    Mirjam H M Heemskerk;Manja Hoogeboom;Roelof A de Paus;Michel G D Kester

  • Mixed T cell receptor dimers harbor potentially harmful neoreactivity

    Marleen M. van Loenen;Renate de Boer;Avital L. Amir;Renate S. Hagedoorn

  • Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer.

    Mirjam H.M. Heemskerk;Manja Hoogeboom;Renate S. Hagedoorn;Michel G.D. Kester

  • Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

    Mirjam H. M. Heemskerk;Renate S. Hagedoorn;Menno A. W. G. van der Hoorn;Lars T. van der Veken

  • Hematopoietic SCT in Europe 2013: Recent trends in the use of alternative donors showing more haploidentical donors but fewer cord blood transplants

    J R Passweg;H Baldomero;P Bader;C Bonini

  • New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population

    Inge Jedema;Nicole M. van der Werff;Renée M. Y. Barge;Roel Willemze

  • PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation.

    Wieger J. Norde;Frans Maas;Willemijn Hobo;Alan Korman

  • UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition.

    Mario H. J. Vogt;Els Goulmy;Freke M. Kloosterboer;Els Blokland

  • Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia.

    Dyantha I. van der Lee;Rogier M. Reijmers;Maria W. Honders;Renate S. Hagedoorn

  • Minor histocompatibility antigens in human stem cell transplantation

    J.H.Frederik Falkenburg;Lisette van de Corput;Erik W.A Marijt;Roel Willemze

  • The DBY gene codes for an HLA-DQ5 restricted human male-specific minor histocompatibility antigen involved in graft versus host disease.

    Mario H. J. Vogt;Joost W. van den Muijsenberg;Els Goulmy;Eric Spierings

  • Hematopoietic SCT in Europe: data and trends in 2011

    J R Passweg;H Baldomero;M Bregni;S Cesaro

  • Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC).

    WE Fibbe;J Van Damme;A Billiau;N Duinkerken

  • Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

    Marieke Griffioen;Esther H.M. van Egmond;Michel G.D. Kester;Roel Willemze

  • NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

    David L. Porter;Edwin P. Alyea;Joseph H. Antin;Marcos DeLima

  • Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

    Anniek B. van der Waart;Noortje M. P. van de Weem;Frans Maas;Cynthia S. M. Kramer

  • αβ T-Cell Receptor Engineered γδ T Cells Mediate Effective Antileukemic Reactivity

    Lars T. van der Veken;Renate S. Hagedoorn;Marleen M. van Loenen;Roel Willemze

Frequent Co-Authors

Mirjam H.M. Heemskerk
Mirjam H.M. Heemskerk Leiden University Medical Center
Roel Willemze
Roel Willemze Leiden University Medical Center
Peter A. van Veelen
Peter A. van Veelen Leiden University Medical Center
Harry Dolstra
Harry Dolstra Radboud University
Willem E. Fibbe
Willem E. Fibbe Leiden University Medical Center
Henk-Jan Guchelaar
Henk-Jan Guchelaar Leiden University Medical Center
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Joop H. Jansen
Joop H. Jansen Radboud University
Els Goulmy
Els Goulmy Leiden University Medical Center
Jaap T. van Dissel
Jaap T. van Dissel Leiden University Medical Center

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