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Microbiology

D-Index
48
Citations
7205
World Ranking
4713
National Ranking
325

Overview

Wolfgang Uckert is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research primarily focuses on areas spanning Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. The subfields of study linked to their work include Oncology, Immunology, Molecular Biology, Electrical and Electronic Engineering, and Genetics.

The scientist's main topics of interest revolve around CAR-T cell therapy research, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Silicon Carbide Semiconductor Technologies, Immunotherapy and Immune Responses, Virus-based gene therapy research, and RNA Interference and Gene Delivery.

Wolfgang Uckert has published extensively in several venues, with frequent contributions to Human Gene Therapy, Nature Communications, the European Journal of Immunology, and Molecular Therapy - Methods & Clinical Development.

Significant recent publications include:

  • "CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells," 2021, Nature Communications
  • "CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes," 2020, Human Gene Therapy
  • "Generation of Epstein-Barr Virus Antigen-Specific T Cell Receptors Recognizing Immunodominant Epitopes of LMP1, LMP2A, and EBNA3C for Immunotherapy," 2021, Human Gene Therapy
  • "Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using nonredundant immune mechanisms in mice," 2022, European Journal of Immunology
  • "Gene Therapy "Made in Germany": A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy," 2021, Human Gene Therapy

Wolfgang Uckert commonly collaborates with other researchers, including Mario Bunse, Hinrich Abken, Hildegard Büning, Janina Marie Pfeilschifter, and Julia Bluhm.

Best Publications

  • Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

    Gavin M Bendle;Carsten Linnemann;Anna I Hooijkaas;Laura Bies

  • Retroviral Vectors for High-Level Transgene Expression in T Lymphocytes

    Boris Engels;Hakan Cam;Thomas Schüler;Stefano Indraccolo

  • Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

    Thomas Kammertoens;Christian Friese;Christian Friese;Ainhoa Arina;Christian Idel

  • Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases

    Christian Beltinger;Simone Fulda;Thomas Kammertoens;Eric Meyer

  • T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

    Karin Krebs;Nina Böttinger;Li–Rung Huang;Markus Chmielewski

  • Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells.

    Shao-An Xue;Liquan Gao;Daniel Hart;Roopinder Gillmore

  • Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.

    J. Stitz;C.J. Buchholz;M. Engelstädter;W. Uckert

  • Minimal Amino Acid Exchange in Human TCR Constant Regions Fosters Improved Function of TCR Gene-Modified T Cells

    Daniel Sommermeyer;Wolfgang Uckert;Wolfgang Uckert

  • Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.

    Andreas Gogol-Döring;Ismahen Ammar;Saumyashree Gupta;Mario Bunse

  • Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette.

    Matthias Leisegang;Boris Engels;Peter Meyerhuber;Elisa Kieback

  • Designer T cells by T cell receptor replacement.

    Daniel Sommermeyer;Julia Neudorfer;Monika Weinhold;Monika Weinhold;Matthias Leisegang

  • A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

    Elisa Kieback;Jehad Charo;Daniel Sommermeyer;Thomas Blankenstein

  • TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer

    Magdalena Nauerth;Bianca Weißbrich;Robert Knall;Tobias Franz

  • Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.

    W. Uckert;T. Kammertöns;K. Haack;Z. Qin

  • Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

    Elisa Kieback;Elisa Kieback;Ellen Hilgenberg;Ulrik Stervbo;Vicky Lampropoulou

  • Targeting cancer-specific mutations by T cell receptor gene therapy

    Thomas Blankenstein;Matthias Leisegang;Wolfgang Uckert;Hans Schreiber

  • Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity

    Susanne Wilde;Daniel Sommermeyer;Bernhard Frankenberger;Matthias Schiemann

  • MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors

    Matthias Leisegang;Susanne Wilde;Stefani Spranger;Slavoljub Milosevic

  • RNA Levels of Human Retrovirus Receptors Pit1 and Pit2 Do Not Correlate with Infectibility by Three Retroviral Vector Pseudotypes

    Wolfgang Uckert;Gerald Willimsky;Finn Skou Pedersen;Thomas Blankenstein

  • Distinguishing features of microglia- and monocyte-derived macrophages after stroke.

    Golo Kronenberg;Ria Uhlemann;Nadine Richter;Friederike Klempin;Friederike Klempin

  • T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.

    Christina Dargel;Michal Bassani-Sternberg;Julia Hasreiter;Fabio Zani

Frequent Co-Authors

Thomas Blankenstein
Thomas Blankenstein Max Delbrück Center for Molecular Medicine
Dirk H. Busch
Dirk H. Busch Technical University of Munich
Ulrike Protzer
Ulrike Protzer Technical University of Munich
Hans J. Stauss
Hans J. Stauss University College London
Zsuzsanna Izsvák
Zsuzsanna Izsvák Max Delbrück Center for Molecular Medicine
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Hinrich Abken
Hinrich Abken University of Regensburg
Christian Peschel
Christian Peschel Technical University of Munich
Helmut Kettenmann
Helmut Kettenmann Shenzhen Institutes of Advanced Technology

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