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Immunology

D-Index
60
Citations
11799
World Ranking
3346
National Ranking
130

Overview

Mirjam H.M. Heemskerk is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with substantial contributions to subfields such as Immunology, Oncology, Infectious Diseases, Molecular Biology, and Hematology.

Their research topics focus on various areas of immunological and oncological science, including:

  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19

Heemskerk has published numerous articles in a variety of scientific journals. Their frequent publication venues include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • The Journal of Immunology
  • iScience

Recent significant papers include:

  • "Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells," 2022, Cancer Cell
  • "Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19," 2021, Nature Immunology
  • "The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses," 2020, Immunity
  • "Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint," 2021, Nature Communications
  • "Antibody Response in Immunocompromised Patients With Hematologic Cancers Who Received a 3-Dose mRNA-1273 Vaccination Schedule for COVID-19," 2022, JAMA Oncology

The scientist often collaborates with a range of coauthors, notably:

  • Renate S. Hagedoorn
  • J.H. Frederik Falkenburg
  • Dennis F.G. Remst
  • Marieke Griffioen
  • Anne K. Wouters

Best Publications

  • Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34+ cells in NOD/SCID mice

    Willy A Noort;Alwine B Kruisselbrink;Pieternella S in't Anker;Marjolein Kruger

  • Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.

    W. A. Erik Marijt;Mirjam H. M. Heemskerk;Freke M. Kloosterboer;Els Goulmy

  • Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

    Mirjam H.M. Heemskerk;Bianca Blom;Garry Nolan;Alexander P.A. Stegmann

  • Allo-HLA reactivity of virus-specific memory T cells is common.

    Avital L. Amir;Lloyd J. A. D'Orsogna;Dave L. Roelen;Marleen M. van Loenen

  • Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.

    Sine Reker Hadrup;Sine Reker Hadrup;Arnold H Bakker;Arnold H Bakker;Chengyi J Shu;Rikke S Andersen

  • Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region.

    Mirjam H M Heemskerk;Manja Hoogeboom;Roelof A de Paus;Michel G D Kester

  • Mixed T cell receptor dimers harbor potentially harmful neoreactivity

    Marleen M. van Loenen;Renate de Boer;Avital L. Amir;Renate S. Hagedoorn

  • Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer.

    Mirjam H.M. Heemskerk;Manja Hoogeboom;Renate S. Hagedoorn;Michel G.D. Kester

  • Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

    Mirjam H. M. Heemskerk;Renate S. Hagedoorn;Menno A. W. G. van der Hoorn;Lars T. van der Veken

  • Early stages in the development of human T, natural killer and thymic dendritic cells

    H. Spits;B. Blom;A.-C. Jaleco;K. Weijer

  • Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia.

    Dyantha I. van der Lee;Rogier M. Reijmers;Maria W. Honders;Renate S. Hagedoorn

  • High-throughput identification of antigen-specific TCRs by TCR gene capture

    Carsten Linnemann;Bianca Heemskerk;Pia Kvistborg;Roelof J C Kluin

  • Safety of retroviral gene marking with a truncated NGF receptor.

    C. Bonini;M. Grez;C. Traversari;F. Ciceri

  • Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7

    Arnold H. Bakker;Rieuwert Hoppes;Carsten Linnemann;Mireille Toebes

  • TCR Gene Rearrangements and Expression of the Pre-T Cell Receptor Complex During Human T-Cell Differentiation

    B. Blom;M. C. M. Verschuren;M. C. M. Verschuren;M. H. M. Heemskerk;M. H. M. Heemskerk;A. Q. Bakker;A. Q. Bakker

  • Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

    Marieke Griffioen;Esther H.M. van Egmond;Michel G.D. Kester;Roel Willemze

  • Designer T cells by T cell receptor replacement.

    Daniel Sommermeyer;Julia Neudorfer;Monika Weinhold;Monika Weinhold;Matthias Leisegang

  • Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile

    Daniëlle Krijgsman;Daniëlle Krijgsman;Natasja L. de Vries;Natasja L. de Vries;Anni Skovbo;Morten N. Andersen

  • Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

    Unknown

  • αβ T-Cell Receptor Engineered γδ T Cells Mediate Effective Antileukemic Reactivity

    Lars T. van der Veken;Renate S. Hagedoorn;Marleen M. van Loenen;Roel Willemze

  • PRAME-Specific Allo-HLA–Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer

    Avital L. Amir;Dirk M. van der Steen;Marleen M. van Loenen;Renate S. Hagedoorn

  • The human leukocyte antigen-presented ligandome of B lymphocytes.

    Chopie Hassan;Michel G.D. Kester;Arnoud H. de Ru;Pleun Hombrink

Frequent Co-Authors

J.H. Frederik Falkenburg
J.H. Frederik Falkenburg Leiden University Medical Center
Peter A. van Veelen
Peter A. van Veelen Leiden University Medical Center
Roel Willemze
Roel Willemze Leiden University Medical Center
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Frans H.J. Claas
Frans H.J. Claas Leiden University Medical Center
Sine Reker Hadrup
Sine Reker Hadrup Technical University of Denmark
Hergen Spits
Hergen Spits University of Amsterdam
Jamie Rossjohn
Jamie Rossjohn Monash University
Hans J. Stauss
Hans J. Stauss University College London

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