D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 48 Citations 10,006 135 World Ranking 2935 National Ranking 112

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Gene
  • Cancer

Tuna Mutis mostly deals with Immunology, Cytotoxic T cell, Daratumumab, Isatuximab and Minor histocompatibility antigen. While working in this field, Tuna Mutis studies both Immunology and Pepsin. His study looks at the intersection of Cytotoxic T cell and topics like CD8 with Stem cell and Major histocompatibility complex.

His Daratumumab research incorporates elements of Bone marrow and CD38. He interconnects Cancer research and SLAMF7 in the investigation of issues within Isatuximab. The study incorporates disciplines such as Complement-dependent cytotoxicity and Immunotherapy in addition to Cancer research.

His most cited work include:

  • Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors (623 citations)
  • Daratumumab depletes CD38+ immune-regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma (393 citations)
  • Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia. (393 citations)

What are the main themes of his work throughout his whole career to date?

Tuna Mutis spends much of his time researching Immunology, Cancer research, Multiple myeloma, Cytotoxic T cell and Antigen. Tuna Mutis combines subjects such as Stem cell and Transplantation with his study of Immunology. His Cancer research research includes themes of Ex vivo, Cell culture, Bone marrow and Antibody, Monoclonal antibody.

Tuna Mutis has researched Cytotoxic T cell in several fields, including T cell, CD8 and Molecular biology. His study focuses on the intersection of Antigen and fields such as Antigen presentation with connections in the field of CTL*. Tuna Mutis focuses mostly in the field of Daratumumab, narrowing it down to matters related to CD38 and, in some cases, Retinoic acid.

He most often published in these fields:

  • Immunology (50.00%)
  • Cancer research (40.40%)
  • Multiple myeloma (33.33%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (40.40%)
  • Multiple myeloma (33.33%)
  • Immunotherapy (25.76%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cancer research, Multiple myeloma, Immunotherapy, Antibody and Daratumumab. The Cancer research study combines topics in areas such as Cell culture, Antigen, Bone marrow, CD38 and Monoclonal antibody. His Bone marrow study incorporates themes from Retinoic acid and In vivo.

His Immunotherapy study integrates concerns from other disciplines, such as Bispecific antibody and Combination therapy. His research investigates the connection with Antibody and areas like Chronic lymphocytic leukemia which intersect with concerns in B cell. His Daratumumab study is related to the wider topic of Immunology.

Between 2017 and 2021, his most popular works were:

  • High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action (51 citations)
  • Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells (41 citations)
  • CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia (30 citations)

In his most recent research, the most cited papers focused on:

  • Immune system
  • Gene
  • Cancer

Multiple myeloma, Cancer research, Daratumumab, Immunotherapy and Bone marrow are his primary areas of study. Many of his research projects under Multiple myeloma are closely connected to Cereblon with Cereblon, tying the diverse disciplines of science together. His Cancer research study combines topics from a wide range of disciplines, such as Cell culture, Pomalidomide, Dexamethasone, Antigen and Monoclonal antibody.

His research in Antigen intersects with topics in Cytotoxic T cell and Cytokine secretion. His research on Immunology and Antibody is centered around Daratumumab. His Immunotherapy study which covers Elotuzumab that intersects with Autologous stem-cell transplantation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors

Michel De Weers;Yu Tzu Tai;Michael S. Van Der Veer;Joost M. Bakker.
Journal of Immunology (2011)

646 Citations

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.

W. A. Erik Marijt;Mirjam H. M. Heemskerk;Freke M. Kloosterboer;Els Goulmy.
Proceedings of the National Academy of Sciences of the United States of America (2003)

527 Citations

Daratumumab depletes CD38+ immune-regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

Jakub Krejcik;Jakub Krejcik;Tineke Casneuf;Inger S. Nijhof;Bie Verbist.
Blood (2016)

509 Citations

Feasibility of Immunotherapy of Relapsed Leukemia With Ex Vivo–Generated Cytotoxic T Lymphocytes Specific for Hematopoietic System-Restricted Minor Histocompatibility Antigens

Tuna Mutis;Rob Verdijk;Ellen Schrama;Bennie Esendam.
Blood (1999)

446 Citations

Polyriboinosinic Polyribocytidylic Acid (Poly(I:C)) Induces Stable Maturation of Functionally Active Human Dendritic Cells

Rob M. Verdijk;Tuna Mutis;Ben Esendam;Janine Kamp.
Journal of Immunology (1999)

417 Citations

Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease.

T. Mutis;G. Gillespie;E. Schrama;J. H. F. Falkenburg.
Nature Medicine (1999)

397 Citations

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma.

M. B. Overdijk;S. Verploegen;M. Bogels;M. van Egmond.
mAbs (2015)

356 Citations

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

Jorg Van Loosdregt;Yvonne Vercoulen;Teun Guichelaar;Yoony Y J Gent.
Blood (2010)

347 Citations

In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens

Anne M. Dickinson;Xiao Nong Wang;Lisbet Sviland;Florry A. Vyth-Dreese.
Nature Medicine (2002)

287 Citations

Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

Yvonne van de Wal;Yvonne M. C. Kooy;Peter A. van Veelen;Salvador A. Peña.
Proceedings of the National Academy of Sciences of the United States of America (1998)

283 Citations

Best Scientists Citing Tuna Mutis

J.H. Frederik Falkenburg

J.H. Frederik Falkenburg

Leiden University Medical Center

Publications: 59

Els Goulmy

Els Goulmy

Leiden University Medical Center

Publications: 55

Kenneth C. Anderson

Kenneth C. Anderson

Harvard University

Publications: 51

Frits Koning

Frits Koning

Leiden University Medical Center

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Paul G. Richardson

Paul G. Richardson

Harvard University

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Stanley R. Riddell

Stanley R. Riddell

Fred Hutchinson Cancer Research Center

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Meletios A. Dimopoulos

Meletios A. Dimopoulos

National and Kapodistrian University of Athens

Publications: 37

Jan W. Drijfhout

Jan W. Drijfhout

Leiden University Medical Center

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Ludvig M. Sollid

Ludvig M. Sollid

Oslo University Hospital

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Sagar Lonial

Sagar Lonial

Emory University

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Paul W. H. I. Parren

Paul W. H. I. Parren

Leiden University Medical Center

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Philippe Moreau

Philippe Moreau

University of Nantes

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Nikhil C. Munshi

Nikhil C. Munshi

Harvard University

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Hermann Einsele

Hermann Einsele

University of Würzburg

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Maria-Victoria Mateos

Maria-Victoria Mateos

University of Salamanca

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Peter A. van Veelen

Peter A. van Veelen

Leiden University Medical Center

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Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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