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Margaret A. Lindorfer

Margaret A. Lindorfer

D-Index & Metrics

Microbiology

D-Index
50
Citations
8343
World Ranking
4475
National Ranking
1727

Overview

Margaret A. Lindorfer is affiliated with the University of Virginia in the United States. Their scholarly work primarily lies within the field of Medicine, with a focus on specialized subfields including Radiology, Nuclear Medicine and Imaging, Genetics, Immunology, Physiology, and Pathology and Forensic Medicine.

The scientist's research addresses several main topics including:

  • Monoclonal and Polyclonal Antibodies Research
  • Chronic Lymphocytic Leukemia Research
  • Lymphoma Diagnosis and Treatment
  • Complement system in diseases
  • Erythrocyte Function and Pathophysiology
  • HER2/EGFR in Cancer Research
  • CAR-T cell therapy research

Lindorfer has published in a range of frequent venues such as:

  • Blood
  • Antibodies
  • Blood Cancer Journal
  • JCI Insight
  • Alzheimer's & Dementia Translational Research & Clinical Interventions

Their recent published papers include:

  • DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies, 2020, Blood Cancer Journal
  • C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice, 2020, JCI Insight
  • Antibody-drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms, 2024, Blood
  • FcγR-Mediated Trogocytosis 2.0: Revisiting History Gives Rise to a Unifying Hypothesis, 2022, Antibodies
  • Clearance of amyloid-beta with bispecific antibody constructs bound to erythrocytes, 2020, Alzheimer's & Dementia Translational Research & Clinical Interventions

Frequent collaborators contributing to Lindorfer's research include Ronald P. Taylor, Simone C. Oostindie, Hilma J. van der Horst, Laurens P. Kil, and Kristin Strumane. Ronald P. Taylor is noted as a particularly frequent coauthor with multiple joint publications.

Best Publications

  • Complement is activated by IgG hexamers assembled at the cell surface.

    Christoph A. Diebolder;Christoph A. Diebolder;Frank J. Beurskens;Rob N. de Jong;Roman I. Koning

  • Rituximab Infusion Promotes Rapid Complement Depletion and Acute CD20 Loss in Chronic Lymphocytic Leukemia

    Adam D. Kennedy;Paul V. Beum;Michael D. Solga;David J. DiLillo

  • Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX.

    Andrew W. Pawluczkowycz;Frank J. Beurskens;Paul V. Beum;Margaret A. Lindorfer

  • The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes

    Paul V. Beum;Adam D. Kennedy;Michael E. Williams;Margaret A. Lindorfer

  • Thrice-Weekly Low-Dose Rituximab Decreases CD20 Loss via Shaving and Promotes Enhanced Targeting in Chronic Lymphocytic Leukemia

    Michael E. Williams;John J. Densmore;Andrew W. Pawluczkowycz;Paul V. Beum

  • Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies.

    Ronald P Taylor;Margaret A Lindorfer

  • An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition and killing of CD20+ cells by Rituximab

    Adam D. Kennedy;Michael D. Solga;Theodore A. Schuman;Amos W. Chi

  • Drug insight: the mechanism of action of rituximab in autoimmune disease--the immune complex decoy hypothesis.

    Ronald P Taylor;Margaret A Lindorfer

  • Fcγ-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments.

    Ronald P. Taylor;Margaret A. Lindorfer

  • Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

    Paul V. Beum;Elizabeth M. Peek;Margaret A. Lindorfer;Frank J. Beurskens

  • Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis

    Paul V. Beum;Margaret A. Lindorfer;Frank Beurskens;P. Todd Stukenberg

  • The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment opsonization

    Antonio M. Risitano;Rosario Notaro;Caterina Pascariello;Michela Sica

  • Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients

    Frank J. Beurskens;Margaret A. Lindorfer;Mohammed Farooqui;Paul V. Beum

  • Role of the Prenyl Group on the G Protein γ Subunit in Coupling Trimeric G Proteins to A1 Adenosine Receptors

    Hiroshi Yasuda;Margaret A. Lindorfer;Karen A. Woodfork;Julia E. Fletcher

  • IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

    Chang Han Lee;Gabrielle Romain;Wupeng Yan;Makiko Watanabe

  • Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes

    Paul V. Beum;David A. Mack;Andrew W. Pawluczkowycz;Margaret A. Lindorfer

  • Within peripheral blood mononuclear cells, antibody-dependent cellular cytotoxicity of rituximab-opsonized Daudi cells is promoted by NK cells and inhibited by monocytes due to shaving.

    Paul V. Beum;Margaret A. Lindorfer;Ronald P. Taylor

  • Differential Activity of the G Protein β5γ2 Subunit at Receptors and Effectors

    Margaret A. Lindorfer;Chang-Seon Myung;Yoko Savino;Hiroshi Yasuda

  • Facilitation of Signal Onset and Termination by Adenylyl Cyclase

    Klaus Scholich;Jason B. Mullenix;Claus Wittpoth;Helen M. Poppleton

  • Hematin promotes complement alternative pathway-mediated deposition of C3 activation fragments on human erythrocytes: potential implications for the pathogenesis of anemia in malaria.

    Andrew W. Pawluczkowycz;Margaret A. Lindorfer;John N. Waitumbi;Ronald P. Taylor

  • The G Protein β5 Subunit Interacts Selectively with the Gq α Subunit

    Julia E. Fletcher;Margaret A. Lindorfer;Joseph M. DeFilippo;Hiroshi Yasuda

Frequent Co-Authors

Ronald P. Taylor
Ronald P. Taylor University of Virginia
Paul W. H. I. Parren
Paul W. H. I. Parren Leiden University Medical Center
Jan G. J. van de Winkel
Jan G. J. van de Winkel Genmab (United States)
Joanna B. Goldberg
Joanna B. Goldberg Emory University
V. Michael Holers
V. Michael Holers University of Colorado Denver
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Tuna Mutis
Tuna Mutis Vrije Universiteit Amsterdam
Pierre Bruhns
Pierre Bruhns Université Paris Cité
George Georgiou
George Georgiou The University of Texas at Austin
Gerald E. Marti
Gerald E. Marti National Institutes of Health

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