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Leonardo Scapozza

Leonardo Scapozza

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
11355
World Ranking
16582
National Ranking
311

Overview

Leonardo Scapozza is affiliated with the University of Geneva in Switzerland and focuses on interdisciplinary research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their published work encompasses molecular biology, physiology, immunology, genetics, and organic chemistry, reflecting a broad expertise in life sciences.

The research topics that Leonardo Scapozza has contributed to include:

  • Protein Degradation and Inhibitors
  • Diabetes Management and Research
  • Gut Microbiota and Health
  • Diet and Metabolism Studies
  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research
  • Hedgehog Signaling Pathway Studies

Leonardo Scapozza has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Chemistry, PLoS ONE, British Journal of Nutrition, and Cells. These journals reflect an active presence in both preprint and peer-reviewed scientific communities.

Among recent papers authored or co-authored by Leonardo Scapozza are:

  • From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation (2021), Frontiers in Chemistry
  • Heat-stability Study of Various Insulin Types in Tropical Temperature Conditions: New Insights Towards Improving Diabetes Care (2021), PLoS ONE
  • How 'Protein-Docking' Translates into the New Emerging Field of Docking Small Molecules to Nucleic Acids? (2020), Molecules
  • Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach (2023), Journal of Natural Products
  • CEMIP (HYBID, KIAA1199): Structure, Function and Expression in Health and Disease (2022), FEBS Journal

Leonardo Scapozza has collaborated frequently with several researchers, including Sébastien Tardy, Margaux Héritier, Thomas Gurry, Remo Perozzo, and Marco Prunotto. These repeated collaborations indicate established research partnerships and multidisciplinary teamwork.

Best Publications

  • Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

    Shida Yousefi;Remo Perozzo;Inès Schmid;Andrew Ziemiecki

  • Thermodynamics of protein-ligand interactions: history, presence, and future aspects.

    Remo Perozzo;Gerd Folkers;Leonardo Scapozza

  • Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias

    Carlo B Gambacorti-Passerini;Rosalind H Gunby;Rocco Piazza;Annamaria Galietta

  • In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells

    Miriam Puttini;Addolorata Maria Luce Coluccia;Frank Boschelli;Loredana Cleris

  • Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling

    Fred C. Christians;Fred C. Christians;Leonardo Scapozza;Andreas Crameri;Gerd Folkers

  • Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

    Sébastien Conus;Remo Perozzo;Thomas Reinheckel;Christoph Peters

  • Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

    Vincent Jaquet;Leonardo Scapozza;Robert A. Clark;Karl Heinz Krause

  • Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

    Sotirios K. Sotiriou;Irene Kamileri;Natalia Lugli;Konstantinos Evangelou

  • Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

    Deniz Tasdemir;Gabriela Lack;Reto Brun;Peter Rüedi

  • Single-molecule pulling simulations can discern active from inactive enzyme inhibitors.

    Francesco Colizzi;Remo Perozzo;Leonardo Scapozza;Maurizio Recanatini

  • Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.

    Istvan Botos;Leonardo Scapozza;Dachuan Zhang;Lance A. Liotta

  • Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

    Patrycja Nowak-Sliwinska;Patrycja Nowak-Sliwinska;Leonardo Scapozza;Ariel Ruiz i Altaba

  • Tautomerism in computer-aided drug design.

    Pavel Pospisil;Patrick Ballmer;Leonardo Scapozza;Gerd Folkers

  • NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

    Vincent Jaquet;Julien Marcoux;Eric Forest;Kevin G Leidal

  • Molecular dynamics simulation of MHC-peptide complexes as a tool for predicting potential T cell epitopes

    Didier Rognan;Leonardo Scapozza;Gerd Folkers;Angelika Daser

  • The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor.

    Sibylle Kaspar;Remo Perozzo;Stefan Reinelt;Margareta Meyer

  • The different flexibility of c-Src and c-Abl kinases regulates the accessibility of a druggable inactive conformation.

    Silvia Lovera;Ludovico Sutto;Ralitza Boubeva;Leonardo Scapozza

  • From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation.

    Carlotta Cecchini;Sara Pannilunghi;Sébastien Tardy;Leonardo Scapozza

  • Substrate diversity of herpes simplex virus thymidine kinase. Impact Of the kinematics of the enzyme.

    Beatrice D. Pilger;Remo Perozzo;Frank Alber;Christine Wurth

  • In Vitro and In Vivo Activity of SKI-606, a Novel Abl/Src Inhibitor, Against Imatinib Resistant BCR-ABL+ Neoplastic Cells.

    Miriam Puttini;Addolorata M.L. Coluccia;Frank Boschelli;Anna Franceschino

Frequent Co-Authors

Gerd Folkers
Gerd Folkers ETH Zurich
Carlo Gambacorti-Passerini
Carlo Gambacorti-Passerini University of Milano-Bicocca
Robert Gurny
Robert Gurny University of Geneva
Reto Crameri
Reto Crameri University of Zurich
Hubert Hilbi
Hubert Hilbi Ludwig-Maximilians-Universität München
Thierry Soldati
Thierry Soldati University of Geneva
Andrea Cavalli
Andrea Cavalli Italian Institute of Technology
Oriano Marin
Oriano Marin University of Padua
Lorenzo A. Pinna
Lorenzo A. Pinna University of Padua
Karl-Heinz Krause
Karl-Heinz Krause University of Geneva

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