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Molecular Biology

D-Index
77
Citations
19713
World Ranking
1116
National Ranking
88

Overview

Florence I. Raynaud is affiliated with the Institute of Cancer Research in the United Kingdom and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research activity spans molecular biology, oncology, pulmonary and respiratory medicine, genetics, and cancer research. The scientist's work is characterized by a focus on protein degradation and inhibitors, CAR-T cell therapy research, ubiquitin and proteasome pathways, prostate cancer treatment and research, glioma diagnosis and treatment, metabolomics and mass spectrometry studies, and heat shock proteins research.

Recent research papers authored or co-authored by this scientist include:

  • Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non- BRCA1/2-Mutant Cancers, 2020, Cancer Discovery
  • Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance, 2023, Nature
  • A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer, 2020, Annals of Oncology
  • Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders, 2020, Journal of Medicinal Chemistry
  • Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers, 2020, Cancer Discovery

Frequent co-authors include:

  • Angela Hayes
  • Ruth Ruddle
  • Rosemary Burke
  • Udai Banerji
  • Olivier A. Pierrat

The scientist often publishes in a variety of journals and venues, with multiple publications appearing in:

  • Journal of Medicinal Chemistry
  • Cancer Research
  • Neuro-Oncology
  • Clinical Cancer Research
  • Nature Communications

Florence I. Raynaud's body of work engages primarily with studies related to molecular biology and oncology, which aligns with their active research contributions in cancer discovery and therapeutic approaches.

Best Publications

  • The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer†

    Adrian J. Folkes;Khatereh Ahmadi;Wendy K. Alderton;Sonia Alix

  • Effect of sleep deprivation on the human metabolome.

    Sarah K. Davies;Joo Ern Ang;Victoria L. Revell;Ben Holmes

  • NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

    Suzanne A Eccles;Andy Massey;Florence I Raynaud;Swee Y Sharp

  • 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

    Paul A. Brough;Wynne Aherne;Xavier Barril;Jenifer Borgognoni

  • Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

    Florence I. Raynaud;Suzanne Eccles;Paul A. Clarke;Angela Hayes

  • Phase I Clinical Trial of the CYP17 Inhibitor Abiraterone Acetate Demonstrating Clinical Activity in Patients With Castration-Resistant Prostate Cancer Who Received Prior Ketoconazole Therapy

    Charles J. Ryan;Matthew R. Smith;Lawrence Fong;Jonathan E. Rosenberg

  • Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

    Paul Workman;Paul A. Clarke;Florence I. Raynaud;Rob L.M. van Montfort

  • Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

    Florence I. Raynaud;Suzanne A. Eccles;Sonal Patel;Sonia Alix

  • Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.

    Lindsay Stimson;Martin G. Rowlands;Yvette M. Newbatt;Nicola F. Smith

  • Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models.

    Udai Banerji;Michael Walton;Florence Raynaud;Rachel Grimshaw

  • Small Molecule Antagonists of the σ-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo

    Barbara A Spruce;Lorna A Campbell;Niall McTavish;Michelle A Cooper

  • Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2- d ]pyrimidine derivatives as novel PI3 kinase p110α inhibitors

    Masahiko Hayakawa;Hiroyuki Kaizawa;Hiroyuki Moritomo;Tomonobu Koizumi

  • Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473).

    J Holford;F Raynaud;B A Murrer;K Grimaldi

  • Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.

    Masahiko Hayakawa;Hiroyuki Kaizawa;Ken-Ichi Kawaguchi;Noriko Ishikawa

  • Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

    Jane Renshaw;Kathryn R. Taylor;Ryan Bishop;Melanie Valenti

  • Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

    Swee Y. Sharp;Chrisostomos Prodromou;Kathy Boxall;Marissa V. Powers

  • Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2 -a]pyridines as novel PI3 kinase p110α inhibitors

    Masahiko Hayakawa;Ken-Ichi Kawaguchi;Hiroyuki Kaizawa;Tomonobu Koizumi

  • In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202

    Florence I Raynaud;Steven R Whittaker;Peter M Fischer;Steven McClue

  • Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors

    S. J. Shuttleworth;F. A. Silva;A. R.L. Cecil;C. D. Tomassi

  • Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns.

    A S Moore;A Faisal;D Gonzalez de Castro;V Bavetsias

Frequent Co-Authors

Paul Workman
Paul Workman Institute of Cancer Research
Suzanne A. Eccles
Suzanne A. Eccles Institute of Cancer Research
Ian Judson
Ian Judson Institute of Cancer Research
Johann S. de Bono
Johann S. de Bono Institute of Cancer Research
Ian Collins
Ian Collins PharmEnable Therapeutics
Lloyd R. Kelland
Lloyd R. Kelland University College London
Andrew D.J. Pearson
Andrew D.J. Pearson Royal Marsden NHS Foundation Trust
Chris Jones
Chris Jones Institute of Cancer Research
Paul Pévet
Paul Pévet University of Strasbourg
Martin O. Leach
Martin O. Leach Royal Marsden NHS Foundation Trust

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