World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
11896
World Ranking
9866
National Ranking
4322

Overview

Larry H. Matherly is affiliated with Wayne State University in the United States. Their research work primarily focuses on the intersection of biochemistry, genetics, and molecular biology, with a substantial contribution to medicine. Their expertise covers a broad spectrum of subfields including molecular biology, cancer research, rheumatology, oncology, and infectious diseases.

The main research topics explored by Larry H. Matherly include:

  • Biochemical and Molecular Research
  • Folate and B Vitamins Research
  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • HIV/AIDS drug development and treatment
  • Cancer-related Molecular Pathways
  • Epigenetics and DNA Methylation

Their recent papers illustrate a focus on cancer metabolism, therapeutic targeting, and molecular pathways associated with cancer cells. Notable publications include:

  • Lipid metabolism reprogramming in renal cell carcinoma, 2021, Cancer and Metastasis Reviews
  • Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer, 2020, Molecular Cancer Therapeutics
  • Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds, 2020, British Journal of Cancer
  • FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis, 2022, Nature Communications
  • Folate transporter dynamics and therapy with classic and tumor-targeted antifolates, 2021, Scientific Reports

Larry H. Matherly has collaborated frequently with several researchers, including:

  • Zhanjun Hou
  • Aleem Gangjee
  • Carrie O'Connor
  • Xun Bao
  • Md. Junayed Nayeen

The scientist's research has been disseminated in multiple publication venues with a recurring presence in:

  • Cancer Research
  • Molecular Cancer Therapeutics
  • Scientific Reports
  • Bioorganic & Medicinal Chemistry
  • Cancer Research Communications

Best Publications

  • Membrane transport of folates.

    Larry H. Matherly;I. David Goldman

  • Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.

    Rongbao Zhao;Larry H. Matherly;I. David Goldman

  • Human reduced folate carrier: translation of basic biology to cancer etiology and therapy.

    Larry H. Matherly;Zhanjun Hou;Yijun Deng

  • The cellular pharmacology of methotrexate

    I.David Goldman;Larry H. Matherly

  • Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin.

    Jeffrey W. Taub;Xi Huang;Larry H. Matherly;Mark L. Stout

  • Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells.

    So C. Wong;Susan A. Proefke;Alok Bhushan;Larry H. Matherly

  • Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines.

    Sezen Gurdag;Jayant Khandare;Sarah Stapels;Larry H. Matherly

  • New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

    Eric C. Hales;Jeffrey W. Taub;Larry H. Matherly

  • Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human feces.

    Jordan M. Nechvatal;Jeffrey L. Ram;Marc D. Basson;Marc D. Basson;Phanramphoei Namprachan

  • Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia.

    Jeffrey W. Taub;Larry H. Matherly;Mark L. Stout;Steven A. Buck

  • The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

    Sita Kugel Desmoulin;Zhanjun Hou;Aleem Gangjee;Larry H. Matherly

  • The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter.

    Johnathan R Whetstine;Robin M Flatley;Larry H Matherly

  • The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

    A Larson Gedman;Q Chen;S Kugel Desmoulin;Y Ge

  • Expression of MRP4 Confers Resistance to Ganciclovir and Compromises Bystander Cell Killing

    Masashi Adachi;Janardhan Sampath;Lu Bin Lan;Daxi Sun

  • Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

    Andong Qiu;Sang Hee Min;Michaela Jansen;Usha Malhotra

  • Role of MRP4 and MRP5 in biology and chemotherapy.

    Janardhan Sampath;Masashi Adachi;Sigrid Hatse;Lieve Naesens

  • Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency.

    Hamid M. Said;Nabendu Chatterjee;Riaz Ul Haq;Veedamali S. Subramanian

  • Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1

    Zhanjun Hou;Larry H. Matherly

  • High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia.

    Jeffrey W. Taub;Mark A. Konrad;Yubin Ge;John M. Naber

  • The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation.

    Maoxiang Li;Jun Ying Zhou;Yubin Ge;Larry H. Matherly

Frequent Co-Authors

Jeffrey W. Taub
Jeffrey W. Taub Wayne State University
Godefridus J. Peters
Godefridus J. Peters Gdańsk Medical University
John D. Schuetz
John D. Schuetz St. Jude Children's Research Hospital
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Roy L. Kisliuk
Roy L. Kisliuk Tufts University
Marc D. Basson
Marc D. Basson University of North Dakota
Christopher P. Leamon
Christopher P. Leamon Fusion Pharmaceuticals
Lawrence H. Lash
Lawrence H. Lash Wayne State University
I. David Goldman
I. David Goldman Albert Einstein College of Medicine

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring online degrees related to Biology and Biochemistry can open doors to a variety of rewarding career paths in healthcare, research, and beyond. For those interested in nutrition, there are options to pursue one of the fastest nutrition degree programs online, making it easier to enter the workforce quickly with specialized knowledge.

If your goals involve leadership roles in healthcare, an affordable online mba healthcare management can prepare you for advanced positions while keeping education costs manageable. In addition, the growing field of health informatics has increased demand for professionals with certifications such as certified professional coder, which can be earned online and lead to versatile job options.

Curious about job prospects and earning potential? Learning medical coding salary expectations can help you assess if this flexible, in-demand career suits your interests, especially for those with a background in biology or biochemistry. Online education makes these transitions and advancements more accessible than ever.

Best Scientists Citing Larry H. Matherly

Trending Scientists