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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
16072
World Ranking
6042
National Ranking
2846

Overview

John D. Crispino is affiliated with Northwestern University in the United States. Their research spans several areas within medicine and molecular biology, with a strong focus on hematology and related subfields. Their work broadly covers acute myeloid leukemia, myeloproliferative neoplasms, and acute lymphoblastic leukemia, along with molecular processes such as ubiquitin and proteasome pathways and RNA modifications in cancer.

The scientist's publications include contributions to high-impact journals and various fields of study. Some recent notable papers are:

  • DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3, 2021, Journal of Clinical Investigation
  • Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer, 2021, Science Advances
  • IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms, 2022, Blood
  • The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target, 2022, Oncogene
  • LKB1/ STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms, 2021, Cancer Discovery

The scientist collaborates frequently with several colleagues, including:

  • Anitria Cotton
  • Te Ling
  • Johanna Melo-Cardenas
  • Rahul S. Bhansali
  • Jeremy Q. Wen

John D. Crispino has published extensively in several scientific venues, with repeated contributions to:

  • Blood (30 publications)
  • Leukemia (6 publications)
  • Experimental Hematology (5 publications)
  • Journal of Clinical Investigation (3 publications)
  • Science Advances (2 publications)

Their main fields of study include medicine, with 117 publications, and biochemistry, genetics, and molecular biology, accounting for 48 publications. Subfields include hematology (44 publications), molecular biology (43 publications), genetics (24 publications), public health, environmental and occupational health (14 publications), and rheumatology (7 publications).

The primary topics of research encompass:

  • Acute Myeloid Leukemia Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Acute Lymphoblastic Leukemia research
  • Chronic Myeloid Leukemia Treatments
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer
  • Eosinophilic Disorders and Syndromes

Best Publications

  • Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome.

    Joshua Wechsler;Marianne Greene;Michael A. McDevitt;John Anastasi

  • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

    Omar Abdel-Wahab;Ann Mullally;Cyrus Hedvat;Guillermo Garcia-Manero

  • Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.

    Kim E. Nichols;John D. Crispino;Mortimer Poncz;James G. White

  • Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.

    Sergei G. Tevosian;Kenneth H. Albrecht;John D. Crispino;John D. Crispino;Yuko Fujiwara;Yuko Fujiwara

  • The aurora kinases in cell cycle and leukemia

    Benjamin Goldenson;John D. Crispino

  • Activating alleles of JAK3 in acute megakaryoblastic leukemia

    Denise K. Walters;Denise K. Walters;Thomas Mercher;Ting Lei Gu;Thomas O'Hare;Thomas O'Hare

  • Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors

    John D. Crispino;Maya B. Lodish;Beth L. Thurberg;Silvio H. Litovsky

  • Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.

    John D Crispino;John D Crispino;Maya B Lodish;Maya B Lodish;Joel P MacKay;Stuart H Orkin;Stuart H Orkin

  • Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.

    Sébastien Malinge;Shai Izraeli;John D. Crispino

  • The mitochondrial respiratory chain is essential for haematopoietic stem cell function

    Elena Ansó;Samuel E. Weinberg;Lauren P. Diebold;Benjamin J. Thompson

  • Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders

    John M. Joslin;Anthony A. Fernald;Thelma R. Tennant;Elizabeth M. Davis

  • GATA1 in normal and malignant hematopoiesis.

    John D. Crispino

  • Transcription factor networks in erythroid cell and megakaryocyte development.

    Louis C. Doré;John D. Crispino

  • Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis

    Gina Mundschau;Sandeep Gurbuxani;Alan S. Gamis;Marianne E. Greene

  • Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome.

    Sandeep Gurbuxani;Paresh Vyas;Paresh Vyas;John D. Crispino;John D. Crispino

  • Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

    Sébastien Malinge;Meghan Bliss-Moreau;Gina Kirsammer;Lauren Diebold

  • Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

    Xun Wang;John D. Crispino;Danielle L. Letting;Minako Nakazawa

  • GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

    Aaron N. Chang;Alan B. Cantor;Yuko Fujiwara;Maya B. Lodish

  • Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP.

    John D. Crispino;Benjamin J. Blencowe;Phillip A. Sharp

  • GATA factor mutations in hematologic disease.

    John D. Crispino;Marshall S. Horwitz

Frequent Co-Authors

Ayalew Tefferi
Ayalew Tefferi Mayo Clinic
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Jeffrey W. Taub
Jeffrey W. Taub Wayne State University
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Amittha Wickrema
Amittha Wickrema University of Chicago
Stuart H. Orkin
Stuart H. Orkin Harvard University
Ali Shilatifard
Ali Shilatifard Northwestern University
Paresh Vyas
Paresh Vyas University of Oxford
Michelle M. Le Beau
Michelle M. Le Beau University of Chicago

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