The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity.
Toyohide Shinkawa;Kazuyasu Nakamura;Naoko Yamane;Emi Shoji-Hosaka.
Journal of Biological Chemistry (2003)
Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity.
Naoko Yamane-Ohnuki;Satoko Kinoshita;Miho Inoue-Urakubo;Machi Kusunoki.
Biotechnology and Bioengineering (2004)
Antibody composition which specifically binds to cd20
Kenya Shitara;Mikiko Sakurada;Kazuhisa Uchida;Toyohide Shinkawa.
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans
Asako Sawano;Shinobu Iwai;Yoshiko Sakurai;Mikito Ito.
Fused protein composition
Shitara Kenya;Hosaka Emi;Natsume Akito;Wakitani Masako.
Process for purifying antibody
Toyohide Shinkawa;Kazuhisa Uchida;Motoo Yamasaki;Emi Hosaka.
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types.
Yutaka Kanda;Tsuyoshi Yamada;Katsuhiro Mori;Akira Okazaki.
METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa
Kazuyasu Nakamura;Kenya Shitara.
Antibody composition-containing medicament
Rinpei Niwa;Kenya Shitara.
Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma
Rinpei Niwa;Emi Shoji-Hosaka;Mikiko Sakurada;Toyohide Shinkawa.
Cancer Research (2004)
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