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Immunology
Netherlands
2022

D-Index & Metrics

Immunology

D-Index
111
Citations
43704
World Ranking
475
National Ranking
18

Research.com Recognitions

  • 2022 - Research.com Immunology in Netherlands Leader Award

Overview

Paul W. H. I. Parren is affiliated with Leiden University Medical Center in the Netherlands. Their research spans multiple fields and topics primarily within medicine and immunology, with a substantial focus on antibody-related studies and cancer immunotherapy.

The main fields of study associated with this scientist include:

  • Medicine
  • Immunology and Microbiology

Within these fields, more specific subfields reflect their research interests:

  • Immunology
  • Radiology, Nuclear Medicine and Imaging
  • Oncology
  • Genetics
  • Molecular Biology

Key research topics covered by their work encompass:

  • Monoclonal and Polyclonal Antibodies Research
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Complement system in diseases
  • T-cell and B-cell Immunology
  • Chronic Lymphocytic Leukemia Research
  • Systemic Lupus Erythematosus Research

Their recent publication record includes studies that address mechanisms of antibody function, cancer immunotherapy, and novel antibody therapeutics. Notable recent papers are:

  • Avidity in antibody effector functions and biotherapeutic drug design (2022) published in Nature Reviews Drug Discovery
  • Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future (2022) published in Frontiers in Immunology
  • DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing (2020) published in EBioMedicine
  • Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET (2021) published in Journal of Biological Chemistry
  • DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies (2020) published in Blood Cancer Journal

Their work appears frequently in several scientific venues, reflecting consistent contributions to immunology and cancer research literature. These venues include:

  • Frontiers in Immunology
  • Proceedings of the National Academy of Sciences
  • Cancer Immunology Research
  • Journal of Clinical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

Throughout their career, Paul W. H. I. Parren has collaborated often with fellow researchers. Frequent co-authors with multiple joint publications include:

  • Janine Schuurman
  • Hans van Vliet
  • Tanja D. de Gruijl
  • Arnon P. Kater
  • Leendert A. Trouw

Best Publications

  • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

    Dennis R. Burton;Jayashree Pyati;Raju Koduri;Stephen J. Sharp

  • Bispecific antibodies: a mechanistic review of the pipeline.

    Aran F Labrijn;Maarten L Janmaat;Janice M Reichert;Paul W H I Parren

  • Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors

    Michel De Weers;Yu Tzu Tai;Michael S. Van Der Veer;Joost M. Bakker

  • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

    Peter D. Kwong;Peter D. Kwong;Michael L. Doyle;Michael L. Doyle;David J. Casper;Claudia Cicala

  • Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.

    Erica Ollmann Saphire;Paul W. H. I. Parren;Ralph Pantophlet;Michael B. Zwick

  • Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

    Marijn van der Neut Kolfschoten;Janine Schuurman;Mario Losen;Wim K. Bleeker

  • Fc receptor but not complement binding is important in antibody protection against HIV

    Ann J. Hessell;Lars Hangartner;Meredith Hunter;Carin E. G. Havenith

  • Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

    Michael B. Zwick;Aran F. Labrijn;Meng Wang;Catherine Spenlehauer

  • Complement is activated by IgG hexamers assembled at the cell surface.

    Christoph A. Diebolder;Christoph A. Diebolder;Frank J. Beurskens;Rob N. de Jong;Roman I. Koning

  • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

    Jessica L Teeling;Ruth R French;Mark S Cragg;Jeroen van den Brakel

  • Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro

    Paul W. H. I. Parren;Preston A. Marx;Preston A. Marx;Ann J. Hessell;Amara Luckay

  • The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20

    Jessica L. Teeling;Wendy J.M. Mackus;Luus J.J.M. Wiegman;Jeroen H.N. van den Brakel

  • Human monoclonal antibodies against cd20

    Jessica Woodmill Cottage Teeling;Sigrid Ruuls;Martin Glennie;Jan G. J. Van De Winkel

  • Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques.

    Ann J Hessell;Pascal Poignard;Meredith Hunter;Lars Hangartner

  • Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

    M. B. Overdijk;S. Verploegen;M. Bogels;M. van Egmond

  • Effector Function Activities of a Panel of Mutants of a Broadly Neutralizing Antibody against Human Immunodeficiency Virus Type 1

    Marjan Hezareh;Ann J. Hessell;Richard C. Jensen;Jan G. J. van de Winkel

  • On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2.

    P. W. H. I. Parren;P. A. M. Warmerdam;L. C. M. Boeije;J. Arts

  • Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

    Aran F Labrijn;Antonio Ortiz Buijsse;Ewald T J van den Bremer;Annemiek Y W Verwilligen

  • The neutralizing antibody response to HIV-1: viral evasion and escape from humoral immunity.

    P. W. H. I Parren;J. P Moore;D. R Burton;Q. J Sattentau

  • Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

    Aran F. Labrijn;Joyce I. Meesters;Bart E. C. G. de Goeij;Ewald T. J. van den Bremer

  • Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.

    Magdalena Winiarska;Jacek Bil;Ewa Wilczek;Grzegorz M Wilczynski

Frequent Co-Authors

Jan G. J. van de Winkel
Jan G. J. van de Winkel Genmab (United States)
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Ronald P. Taylor
Ronald P. Taylor University of Virginia
Tuna Mutis
Tuna Mutis Vrije Universiteit Amsterdam
Thomas Valerius
Thomas Valerius Kiel University
Margaret A. Lindorfer
Margaret A. Lindorfer University of Virginia
Matthias Peipp
Matthias Peipp Kiel University
Ole Baadsgaard
Ole Baadsgaard Genmab (United States)
Erica Ollmann Saphire
Erica Ollmann Saphire La Jolla Institute For Allergy & Immunology
Henrik J. Ditzel
Henrik J. Ditzel University of Southern Denmark

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