D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 97 Citations 30,975 253 World Ranking 303 National Ranking 10

Overview

What is he best known for?

The fields of study he is best known for:

  • Antibody
  • Immune system
  • Gene

His scientific interests lie mostly in Antibody, Monoclonal antibody, Virology, Immunology and Epitope. His Antibody study incorporates themes from Molecular biology, Antigen and In vivo. Paul W. H. I. Parren has researched Monoclonal antibody in several fields, including Ebolavirus and Cytotoxicity.

His Virology study integrates concerns from other disciplines, such as Peptide library and Phage display. His Immunology research focuses on Cancer research and how it connects with Immunotherapy, Growth factor receptor, Mechanism of action and Ex vivo. His Epitope research includes elements of Viral envelope, Glycoprotein and Complementarity determining region.

His most cited work include:

  • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody (1075 citations)
  • Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. (759 citations)
  • Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. (756 citations)

What are the main themes of his work throughout his whole career to date?

Paul W. H. I. Parren mostly deals with Antibody, Immunology, Monoclonal antibody, Molecular biology and Virology. His studies deal with areas such as Cancer research, Antigen and Cytotoxicity as well as Antibody. Paul W. H. I. Parren conducts interdisciplinary study in the fields of Monoclonal antibody and Diagnostic methods through his works.

His biological study spans a wide range of topics, including Cell culture, T cell, Biochemistry, Complement-dependent cytotoxicity and Primary and secondary antibodies. In his work, Immunoglobulin G is strongly intertwined with Cell biology, which is a subfield of Complement system. He has researched Epitope in several fields, including Viral envelope and Binding site.

He most often published in these fields:

  • Antibody (73.17%)
  • Immunology (37.56%)
  • Monoclonal antibody (35.61%)

What were the highlights of his more recent work (between 2016-2021)?

  • Antibody (73.17%)
  • Cancer research (26.34%)
  • Cytotoxicity (19.76%)

In recent papers he was focusing on the following fields of study:

Paul W. H. I. Parren spends much of his time researching Antibody, Cancer research, Cytotoxicity, Immunology and Monoclonal antibody. His Antibody research is multidisciplinary, incorporating elements of Cell, Molecular biology and Antigen. His Molecular biology study incorporates themes from Cell biology, Complement system and Cancer immunotherapy.

His Cancer research study combines topics from a wide range of disciplines, such as Cancer cell, Cancer, Immunotherapy, In vitro and In vivo. His work carried out in the field of Immunology brings together such families of science as Computational biology, Rodent and Neoplasms therapy. In his research, Degranulation is intimately related to Chronic lymphocytic leukemia, which falls under the overarching field of Monoclonal antibody.

Between 2016 and 2021, his most popular works were:

  • Bispecific antibodies: a mechanistic review of the pipeline. (215 citations)
  • Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors. (90 citations)
  • Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors. (90 citations)

In his most recent research, the most cited papers focused on:

  • Antibody
  • Gene
  • Immune system

His primary areas of study are Cancer research, Antibody, Immunology, Immunotherapy and Daratumumab. The various areas that Paul W. H. I. Parren examines in his Cancer research study include Receptor tyrosine kinase, In vivo and Cytotoxicity. In the subject of general Antibody, his work in Immunoglobulin G is often linked to Proteases, thereby combining diverse domains of study.

His studies in Immunotherapy integrate themes in fields like Relapsed refractory, Multiple myeloma and Fc-Gamma Receptor. His Daratumumab research incorporates elements of Tumor microenvironment, Antibody-dependent cell-mediated cytotoxicity, Peripheral blood mononuclear cell, CD38 and Leukemia. His Monoclonal antibody research is multidisciplinary, incorporating perspectives in Cancer cell, Cell culture and Antigen, CD20.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

Dennis R. Burton;Jayashree Pyati;Raju Koduri;Stephen J. Sharp.
Science (1994)

1348 Citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

Frans Rijsewijk;Marcus Schuermann;Els Wagenaar;Paul Parren.
Cell (1987)

1148 Citations

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

Michael B. Zwick;Aran F. Labrijn;Meng Wang;Catherine Spenlehauer.
Journal of Virology (2001)

962 Citations

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.

Erica Ollmann Saphire;Paul W. H. I. Parren;Ralph Pantophlet;Michael B. Zwick.
Science (2001)

927 Citations

Fc receptor but not complement binding is important in antibody protection against HIV

Ann J. Hessell;Lars Hangartner;Meredith Hunter;Carin E. G. Havenith.
Nature (2007)

843 Citations

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

Marijn van der Neut Kolfschoten;Janine Schuurman;Mario Losen;Wim K. Bleeker.
Science (2007)

802 Citations

Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro

Paul W. H. I. Parren;Preston A. Marx;Preston A. Marx;Ann J. Hessell;Amara Luckay.
Journal of Virology (2001)

770 Citations

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

Jessica L Teeling;Ruth R French;Mark S Cragg;Jeroen van den Brakel.
Blood (2004)

716 Citations

The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20

Jessica L. Teeling;Wendy J.M. Mackus;Luus J.J.M. Wiegman;Jeroen H.N. van den Brakel.
Journal of Immunology (2006)

661 Citations

Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors

Michel De Weers;Yu Tzu Tai;Michael S. Van Der Veer;Joost M. Bakker.
Journal of Immunology (2011)

646 Citations

Best Scientists Citing Paul W. H. I. Parren

Dennis R. Burton

Dennis R. Burton

Scripps Research Institute

Publications: 299

David C. Montefiori

David C. Montefiori

Duke University

Publications: 241

John R. Mascola

John R. Mascola

National Institutes of Health

Publications: 163

Barton F. Haynes

Barton F. Haynes

Duke University

Publications: 138

Rogier W. Sanders

Rogier W. Sanders

University of Amsterdam

Publications: 120

John P. Moore

John P. Moore

Cornell University

Publications: 113

Peter D. Kwong

Peter D. Kwong

National Institutes of Health

Publications: 99

Joseph Sodroski

Joseph Sodroski

Harvard University

Publications: 95

Ian A. Wilson

Ian A. Wilson

Scripps Research Institute

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Richard T. Wyatt

Richard T. Wyatt

Scripps Research Institute

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Michel C. Nussenzweig

Michel C. Nussenzweig

Rockefeller University

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Michael S. Seaman

Michael S. Seaman

Beth Israel Deaconess Medical Center

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Susan Zolla-Pazner

Susan Zolla-Pazner

Icahn School of Medicine at Mount Sinai

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Leonidas Stamatatos

Leonidas Stamatatos

Fred Hutchinson Cancer Research Center

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Andrew B. Ward

Andrew B. Ward

Scripps Research Institute

Publications: 76

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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