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Immunology

D-Index
110
Citations
47614
World Ranking
500
National Ranking
302

Overview

Michael S. Seaman is affiliated with the Beth Israel Deaconess Medical Center in the United States. Their research primarily lies at the intersection of medicine and immunology and microbiology, with a significant focus on infectious diseases, virology, and immunology. Within these areas, the scientist has contributed notably to molecular biology and the application of imaging techniques such as radiology and nuclear medicine.

The scientist's work extensively covers topics related to HIV research and treatment, monoclonal and polyclonal antibodies research, and drug development for HIV/AIDS. In addition, a substantial portion of their research addresses SARS-CoV-2 and COVID-19, focusing on clinical research studies, immune cell function and interaction, and vaccines and immunoinformatics approaches.

Recent published papers include:

  • Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host, 2020, New England Journal of Medicine
  • Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic, 2020, JAMA Network Open
  • Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19, 2021, JAMA
  • Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant, 2021, Science
  • Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants, 2021, Science

The scientist frequently publishes in several venues known for high-impact biomedical research. These include bioRxiv (Cold Spring Harbor Laboratory) with 34 publications, Cell with 9 publications, Nature Communications with 7, Journal of Virology with 6, and Cell Reports with 5 publications.

Collaborations have been a key aspect of their research approach. Frequent coauthors include Christy L. Lavine, David C. Montefiori, Michel C. Nussenzweig, Pamela J. Björkman, and Bing Chen, each contributing to multiple joint publications. These collaborations reflect an interdisciplinary engagement across immunology, virology, and molecular biology domains.

Best Publications

  • An immunogenic personal neoantigen vaccine for patients with melanoma

    Patrick A. Ott;Zhuting Hu;Derin B. Keskin;Derin B. Keskin;Sachet A. Shukla;Sachet A. Shukla

  • Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

    Xueling Wu;Zhi Yong Yang;Yuxing Li;Carl Magnus Hogerkorp

  • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.

    Johannes F. Scheid;Hugo Mouquet;Beatrix Ueberheide;Ron Diskin

  • Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.

    Bina Choi;Manish C. Choudhary;James Regan;Jeffrey A. Sparks

  • Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

    Johannes F. Scheid;Hugo Mouquet;Niklas Feldhahn;Michael S. Seaman

  • Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

    Marina Caskey;Florian Klein;Julio C. C. Lorenzi;Michael S. Seaman

  • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

    Dan H. Barouch;James B. Whitney;Brian Moldt;Florian Klein

  • Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies.

    Michael S. Seaman;Holly Janes;Natalie Hawkins;Lauren E. Grandpre

  • Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.

    Hugo Mouquet;Louise Scharf;Zelda Euler;Yan Liu

  • Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

    Stylianos Bournazos;Florian Klein;John Pietzsch;Michael S. Seaman

  • Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

    Florian Klein;Ron Diskin;Ron Diskin;Johannes F. Scheid;Johannes F. Scheid;Christian Gaebler;Christian Gaebler

  • Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.

    Marcella Sarzotti-Kelsoe;Robert T. Bailer;Ellen Turk;Chen-li Lin

  • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

    Florian Klein;Ariel Halper-Stromberg;Joshua A. Horwitz;Henning Gruell;Henning Gruell

  • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

    Masashi Shingai;Yoshiaki Nishimura;Florian Klein;Hugo Mouquet

  • HIV-1 neutralizing antibodies induced by native-like envelope trimers

    Rogier W. Sanders;Rogier W. Sanders;Marit J. Van Gils;Ronald Derking;Devin Sok;Devin Sok

  • Immune Control of an SIV Challenge by a T Cell-Based Vaccine in Rhesus Monkeys

    Jinyan Liu;Kara L. O’Brien;Diana M. Lynch;Nathaniel L. Simmons

  • Combination therapy with anti-HIV-1 antibodies maintains viral suppression

    Pilar Mendoza;Henning Gruell;Lilian Nogueira;Joy A. Pai

  • Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

    Davide Corti;Johannes P. M. Langedijk;Andreas Hinz;Michael S. Seaman

  • Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

    Dan H. Barouch;Dan H. Barouch;Jinyan Liu;Hualin Li;Lori F. Maxfield

  • HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

    Johannes F. Scheid;Johannes F. Scheid;Joshua A. Horwitz;Yotam Bar-On;Edward F. Kreider

  • Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

    Mattia Bonsignori;Kwan Ki Hwang;Xi Chen;Chun Yen Tsao

Frequent Co-Authors

Michel C. Nussenzweig
Michel C. Nussenzweig Rockefeller University
Dan H. Barouch
Dan H. Barouch Harvard Medical School
David C. Montefiori
David C. Montefiori Duke University
Pamela J. Bjorkman
Pamela J. Bjorkman California Institute of Technology
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
John R. Mascola
John R. Mascola ModeX Therapeutics
Lindsey R. Baden
Lindsey R. Baden Brigham and Women's Hospital
Norman L. Letvin
Norman L. Letvin Beth Israel Deaconess Medical Center
Bing Chen
Bing Chen Harvard University
Bette T. Korber
Bette T. Korber Los Alamos National Laboratory

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