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Immunology

D-Index
95
Citations
45816
World Ranking
879
National Ranking
489

Overview

Richard T. Wyatt is affiliated with the Scripps Research Institute in the United States. Their research primarily focuses on immunology, microbiology, and molecular biology, with contributions spanning medicine as well. The main subfields of study include virology, immunology, molecular biology, radiology, nuclear medicine and imaging, and genetics.

The scientist's work extensively covers topics related to HIV research and treatment, monoclonal and polyclonal antibodies research, immunotherapy and immune responses, immune cell function and interaction, vaccines and immunoinformatics approaches, T-cell and B-cell immunology, as well as RNA interference and gene delivery.

Frequent publication venues in which Richard T. Wyatt has contributed include:

  • Cell Reports
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • Pharmaceutics

Some of the recent papers authored or co-authored by Richard T. Wyatt are:

  • Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity, 2020, Cell Reports
  • mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies, 2024, Frontiers in Immunology
  • Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization, 2021, PLoS Pathogens
  • Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response, 2023, Frontiers in Immunology
  • Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes, 2022, Pharmaceutics

Richard T. Wyatt collaborates frequently with a number of researchers, including Javier Guenaga, Gabriel Ozorowski, Gunilla B. Karlsson Hedestam, Richard F. Wilson, and Shridhar Bale.

Best Publications

  • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

    Peter D. Kwong;Richard Wyatt;James Robinson;Raymond W. Sweet

  • The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens.

    Richard Wyatt;Joseph Sodroski

  • Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

    Xueling Wu;Zhi Yong Yang;Yuxing Li;Carl Magnus Hogerkorp

  • CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

    Lijun Wu;Norma P. Gerard;Richard Wyatt;Hyeryun Choe

  • The antigenic structure of the HIV gp120 envelope glycoprotein

    Richard Wyatt;Peter D. Kwong;Elizabeth Desjardins;Raymond W. Sweet

  • A Conserved HIV gp120 Glycoprotein Structure Involved in Chemokine Receptor Binding

    Carlo D. Rizzuto;Richard Wyatt;Richard Wyatt;Nivia Hernández-Ramos;Nivia Hernández-Ramos;Ying Sun;Ying Sun

  • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

    Peter D. Kwong;Peter D. Kwong;Michael L. Doyle;Michael L. Doyle;David J. Casper;Claudia Cicala

  • HIV vaccine design and the neutralizing antibody problem

    Dennis R Burton;Ronald C Desrosiers;Robert W Doms;Wayne C Koff

  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

    Jason S. McLellan;Marie Pancera;Chris Carrico;Jason Gorman

  • Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

    Johannes F. Scheid;Hugo Mouquet;Niklas Feldhahn;Michael S. Seaman

  • Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

    Jinghe Huang;Gilad Ofek;Leo Laub;Mark K. Louder

  • Structural definition of a conserved neutralization epitope on HIV-1 gp120.

    Tongqing Zhou;Ling Xu;Barna Dey;Ann J. Hessell

  • Structure of a V3-Containing HIV-1 gp120 Core

    Chih-chin Huang;Min Tang;Mei-Yun Zhang;Shahzad Majeed

  • Tyrosine Sulfation of the Amino Terminus of CCR5 Facilitates HIV-1 Entry

    Michael Farzan;Tajib Mirzabekov;Peter Kolchinsky;Richard Wyatt

  • Proof of principle for epitope-focused vaccine design

    Bruno Emanuel F. Sousa Correia;John T. Bates;Rebecca J. Loomis;Gretchen Baneyx

  • Energetics of the HIV gp120-CD4 binding reaction

    David G. Myszka;Raymond W. Sweet;Preston Hensley;Michael Brigham-Burke

  • Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope

    Gilad Ofek;Min Tang;Anna Sambor;Hermann Katinger

  • Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.

    R Wyatt;J Moore;M Accola;E Desjardin

  • Structures of HIV-1 gp120 Envelope Glycoproteins from Laboratory-Adapted and Primary Isolates

    Peter D. Kwong;Richard Wyatt;Shahzad Majeed;James Robinson

  • Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.

    Chih Chin Huang;Son N. Lam;Priyamvada Acharya;Min Tang

  • Broad HIV-1 neutralization mediated by CD4-binding site antibodies

    Yuxing Li;Stephen A Migueles;Brent Welcher;Krisha Svehla

Frequent Co-Authors

John R. Mascola
John R. Mascola ModeX Therapeutics
Joseph Sodroski
Joseph Sodroski Harvard Medical School
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Gunilla B. Karlsson Hedestam
Gunilla B. Karlsson Hedestam Karolinska Institute
Sijy O'Dell
Sijy O'Dell National Institute of Allergy and Infectious Diseases
William R. Schief
William R. Schief Scripps Research Institute
Andrew B. Ward
Andrew B. Ward Scripps Research Institute
Krisha McKee
Krisha McKee National Institute of Allergy and Infectious Diseases
Tongqing Zhou
Tongqing Zhou National Institutes of Health

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