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Immunology

D-Index
78
Citations
25072
World Ranking
1736
National Ranking
853

Overview

William R. Schief is affiliated with the Scripps Research Institute in the United States. Their research primarily spans the fields of Immunology and Microbiology, with significant work also situated within Biochemistry, Genetics, and Molecular Biology.

Their main areas of study include Immunology, Virology, Molecular Biology, Infectious Diseases, and Radiology, Nuclear Medicine, and Imaging. Within these fields, the scientist focuses on topics such as HIV Research and Treatment, T-cell and B-cell Immunology, Immune Cell Function and Interaction, Immunotherapy and Immune Responses, vaccines and immunoinformatics approaches, Monoclonal and Polyclonal Antibodies Research, and RNA Interference and Gene Delivery.

Frequent co-authors collaborating with William R. Schief include Shane Crotty, Darrell J. Irvine, Christopher A. Cottrell, Bettina Gröschel, and Erik Georgeson.

The scientist's recent papers demonstrate a range of research interests and venues. Among the notable recent publications are:

  • Macromolecular modeling and design in Rosetta: recent methods and frameworks, 2020, Nature Methods
  • Role of nanoscale antigen organization on B-cell activation probed using DNA origami, 2020, Nature Nanotechnology
  • Engineered immunogen binding to alum adjuvant enhances humoral immunity, 2020, Nature Medicine
  • Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo, 2020, Immunity
  • Vaccination induces HIV broadly neutralizing antibody precursors in humans, 2022, Science

William R. Schief has published extensively in several scientific venues. The most frequent venues include bioRxiv (Cold Spring Harbor Laboratory), OPAL (Open@LaTrobe) (La Trobe University), Immunity, Science Translational Medicine, and Science Immunology.

Best Publications

  • Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

    Xueling Wu;Zhi Yong Yang;Yuxing Li;Carl Magnus Hogerkorp

  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

    Jason S. McLellan;Marie Pancera;Chris Carrico;Jason Gorman

  • Rational HIV immunogen design to target specific germline B cell receptors

    Joseph Jardine;Jean Philippe Julien;Jean Philippe Julien;Sergey Menis;Takayuki Ota

  • A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

    Robert Pejchal;Katie J. Doores;Katie J. Doores;Laura M. Walker;Reza Khayat

  • Proof of principle for epitope-focused vaccine design

    Bruno Emanuel F. Sousa Correia;John T. Bates;Rebecca J. Loomis;Gretchen Baneyx

  • HIV-1 neutralizing antibodies induced by native-like envelope trimers

    Rogier W. Sanders;Rogier W. Sanders;Marit J. Van Gils;Ronald Derking;Devin Sok;Devin Sok

  • Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

    Morgane Rolland;Paul T. Edlefsen;Brendan B. Larsen;Sodsai Tovanabutra

  • HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.

    Joseph G. Jardine;Daniel W. Kulp;Colin Havenar-Daughton;Anita Sarkar

  • Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

    Marie Pancera;Shahzad Majeed;Yih-En Andrew Ban;Lei Chen

  • Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

    Joseph G. Jardine;Takayuki Ota;Devin Sok;Devin Sok;Matthias Pauthner;Matthias Pauthner

  • A Blueprint for HIV Vaccine Discovery

    Dennis R. Burton;Rafi Ahmed;Rafi Ahmed;Dan H. Barouch;Dan H. Barouch;Dan H. Barouch;Salvatore T. Butera

  • HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

    Jon M. Steichen;Daniel W. Kulp;Talar Tokatlian;Amelia Escolano

  • Role of nanoscale antigen organization on B-cell activation probed using DNA origami

    Rémi Veneziano;Rémi Veneziano;Tyson J. Moyer;Matthew B. Stone;Eike Christian Wamhoff

  • Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

    Kimberly M. Cirelli;Kimberly M. Cirelli;Diane G. Carnathan;Diane G. Carnathan;Diane G. Carnathan;Bartek Nogal;Jacob T. Martin;Jacob T. Martin

  • Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

    Andrew T. McGuire;Sam Hoot;Anita M. Dreyer;Adriana Lippy

  • Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

    Amelia Escolano;Jon M. Steichen;Pia Dosenovic;Daniel W. Kulp

  • Elicitation of structure-specific antibodies by epitope scaffolds

    Gilad Ofek;F. Javier Guenaga;William R. Schief;Jeff Skinner

  • Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

    Robert K. Abbott;Jeong Hyun Lee;Jeong Hyun Lee;Sergey Menis;Patrick Skog

  • Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

    Matthias Pauthner;Colin Havenar-Daughton;Colin Havenar-Daughton;Devin Sok;Joseph P. Nkolola;Joseph P. Nkolola

  • Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

    Pia Dosenovic;Lotta Von Boehmer;Amelia Escolano;Joseph Jardine

Frequent Co-Authors

Shane Crotty
Shane Crotty La Jolla Institute For Allergy & Immunology
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Andrew B. Ward
Andrew B. Ward Scripps Research Institute
Richard T. Wyatt
Richard T. Wyatt Scripps Research Institute
David Baker
David Baker University of Washington
Darrell J. Irvine
Darrell J. Irvine Scripps Research Institute
Devin Sok
Devin Sok Scripps Research Institute
Guido Silvestri
Guido Silvestri Emory University
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center

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