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Immunology

D-Index
104
Citations
36043
World Ranking
621
National Ranking
362

Medicine

D-Index
105
Citations
38605
World Ranking
6801
National Ranking
3592

Overview

Darrell J. Irvine is affiliated with the Scripps Research Institute in the United States. Their research primarily spans the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these broad domains, their work frequently touches on subfields such as Immunology, Molecular Biology, Oncology, Virology, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics include Immunotherapy and Immune Responses, Immune Cell Function and Interaction, HIV Research and Treatment, T-cell and B-cell Immunology, RNA Interference and Gene Delivery, Monoclonal and Polyclonal Antibodies Research, and CAR-T cell therapy research.

Among recent published papers authored or co-authored by Darrell J. Irvine are:

  • Enhancing cancer immunotherapy with nanomedicine, 2020, Nature reviews. Immunology
  • Controlling timing and location in vaccines, 2020, Advanced Drug Delivery Reviews

Other relevant highly cited publications associated with their collaborative network include:

  • Role of nanoscale antigen organization on B-cell activation probed using DNA origami, 2020, Nature Nanotechnology
  • STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity, 2022, Nature Materials
  • Engineered immunogen binding to alum adjuvant enhances humoral immunity, 2020, Nature Medicine

Frequent co-authors in Darrell J. Irvine's research include Mariane B. Melo, William R. Schief, Laura Maiorino, Shane Crotty, and Murillo Silva. Collaborative efforts with these researchers have resulted in multiple publications.

Their work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), which accounts for a substantial number of their publications, as well as Regular and Young Investigator Award Abstracts, The Journal of Immunology, Science Immunology, and Nature Biomedical Engineering.

Best Publications

  • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

    Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini

  • Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

    Ayush Verma;Oktay Uzun;Yuhua Hu;Ying Hu

  • Bio-inspired, bioengineered and biomimetic drug delivery carriers

    Jin-Wook Yoo;Darrell J. Irvine;Darrell J. Irvine;Darrell J. Irvine;Dennis E. Discher;Samir Mitragotri

  • Direct observation of ligand recognition by T cells

    Darrell J. Irvine;Marco A. Purbhoo;Michelle Krogsgaard;Mark M. Davis

  • Structure-based programming of lymph-node targeting in molecular vaccines

    Haipeng Liu;Kelly D. Moynihan;Yiran Zheng;Gregory L. Szeto

  • Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

    Matthias T Stephan;James J Moon;Soong Ho Um;Anna Bershteyn

  • Synthetic Nanoparticles for Vaccines and Immunotherapy

    Darrell J. Irvine;Melissa C. Hanson;Kavya Rakhra;Talar Tokatlian

  • Enhancing cancer immunotherapy with nanomedicine.

    Darrell J. Irvine;Eric L. Dane

  • T cell killing does not require the formation of a stable mature immunological synapse

    Marco A Purbhoo;Darrell J Irvine;Darrell J Irvine;Johannes B Huppa;Mark M Davis

  • Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

    Li Tang;Yiran Zheng;Mariane Bandeira de Melo;Llian Mabardi

  • Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

    James J. Moon;Heikyung Suh;Heikyung Suh;Anna Bershteyn;Matthias T. Stephan

  • Engineering synthetic vaccines using cues from natural immunity

    Darrell J. Irvine;Melody A. Swartz;Gregory L. Szeto;Gregory L. Szeto

  • Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

    Kelly D Moynihan;Cary F Opel;Gregory L Szeto;Alice Tzeng

  • Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus

    Lily Y. Koo;Darrell J. Irvine;Anne M. Mayes;Douglas A. Lauffenburger

  • A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

    Margaret E. Ackerman;Brian Moldt;Richard T. Wyatt;Anne-Sophie Dugast

  • Engineering Nano‐ and Microparticles to Tune Immunity

    James J. Moon;Bonnie Huang;Darrell J. Irvine

  • HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

    Jon M. Steichen;Daniel W. Kulp;Talar Tokatlian;Amelia Escolano

  • Role of nanoscale antigen organization on B-cell activation probed using DNA origami

    Rémi Veneziano;Rémi Veneziano;Tyson J. Moyer;Matthew B. Stone;Eike Christian Wamhoff

  • Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

    Kimberly M. Cirelli;Kimberly M. Cirelli;Diane G. Carnathan;Diane G. Carnathan;Diane G. Carnathan;Bartek Nogal;Jacob T. Martin;Jacob T. Martin

  • T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

    Daniela Schmid;Chun Gwon Park;Christina A. Hartl;Nikita Subedi

  • Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

    James J. Moon;Heikyung Suh;Heikyung Suh;Adrienne Victoria Li;Christian F. Ockenhouse

  • Structure-based programming of lymph-node targeting in molecular vaccines

    Haipeng Liu;Kelly Dare Moynihan;Yiran Zheng;Gregory Lee Szeto

Frequent Co-Authors

Shane Crotty
Shane Crotty La Jolla Institute For Allergy & Immunology
William R. Schief
William R. Schief Scripps Research Institute
Dan H. Barouch
Dan H. Barouch Harvard Medical School
James J. Moon
James J. Moon University of Michigan–Ann Arbor
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Guido Silvestri
Guido Silvestri Emory University
Daniel W. Kulp
Daniel W. Kulp The Wistar Institute
Bruce D. Walker
Bruce D. Walker Harvard University

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Related Online Degrees & Career Pathways

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For advanced practice opportunities, exploring what is the easiest np program can help you identify accessible nurse practitioner degrees. These programs often allow Immunology graduates to focus on specialized areas like infectious diseases or immunotherapy, enhancing your career prospects in clinical or research settings.

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