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K. Dane Wittrup

K. Dane Wittrup

MIT
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
27900
World Ranking
3130
National Ranking
1583

K. Dane Wittrup publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where K. Dane Wittrup sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 297 publications — 78th percentile

78% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

K. Dane Wittrup D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where K. Dane Wittrup sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 85 D-Index — 84th percentile

84% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2012 - Member of the National Academy of Engineering For developments in protein engineering, protein expression, and quantitative pharmacology.
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2000 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

K. Dane Wittrup is affiliated with MIT in the United States and has contributed extensively to the fields of medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. Their research spans various subfields including immunology, oncology, molecular biology, radiology, nuclear medicine and imaging, and genetics.

The scientist's work covers several main topics such as immunotherapy and immune responses, CAR-T cell therapy research, cancer immunotherapy and biomarkers, monoclonal and polyclonal antibodies research, immune cell function and interaction, cancer research and treatments, and virus-based gene therapy research.

Frequent co-authors collaborating with K. Dane Wittrup include Darrell J. Irvine, Noor Momin, Allison Sheen, Jordan A. Stinson, and Emi A. Lutz.

The scientist has published multiple papers in prominent venues including Regular and Young Investigator Award Abstracts, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature Biomedical Engineering, and Cancer Research.

Selected recent papers include:

  • Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity (2021, Immunity)
  • Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity (2020, Nature Cancer)
  • High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming (2021, Nature Communications)
  • Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity (2022, Nature Biomedical Engineering)
  • Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer (2023, Immunity)

Awards received by K. Dane Wittrup include:

  • Member of the National Academy of Engineering (2012) for developments in protein engineering, protein expression, and quantitative pharmacology
  • Fellow of the American Association for the Advancement of Science (AAAS) (2011)
  • Fellow of the Indian National Academy of Engineering (INAE) (2000)

Best Publications

  • Isolating and engineering human antibodies using yeast surface display

    Ginger Chao;Wai L Lau;Benjamin J Hackel;Stephen L Sazinsky

  • Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

    Eric T. Boder;Katarina S. Midelfort;K. Dane Wittrup

  • A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

    Michael M. Schmidt;K. Dane Wittrup

  • Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance.

    Greg M. Thurber;Michael M. Schmidt;K. Dane Wittrup

  • Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

    Michael J. Feldhaus;Robert W. Siegel;Lee K. Opresko;James R. Coleman

  • Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

    Kelly D Moynihan;Cary F Opel;Gregory L Szeto;Alice Tzeng

  • Yeast surface display for protein engineering and characterization.

    S Annie Gai;K Dane Wittrup

  • Monovalent, reduced-size quantum dots for imaging receptors on living cells.

    Mark Howarth;Mark Howarth;Wenhao Liu;Sujiet Puthenveetil;Yi Zheng

  • Biophysical properties of the clinical-stage antibody landscape

    Tushar Jain;Tingwan Sun;Stéphanie Durand;Amy Hall

  • Computational design of antibody-affinity improvement beyond in vivo maturation

    Shaun M Lippow;K Dane Wittrup;Bruce Tidor

  • In vitro evolution of a T cell receptor with high affinity for peptide/MHC

    Phillip D. Holler;Philmore O. Holman;Eric V. Shusta;Sean O'Herrin

  • Protein engineering by cell-surface display.

    K.Dane Wittrup

  • Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments

    E V Shusta;R T Raines;A Plückthun;K D Wittrup

  • Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor

    Leyuan Ma;Leyuan Ma;Tanmay Dichwalkar;Jason Y. H. Chang;Benjamin Cossette

  • Directed evolution of a stable scaffold for T-cell receptor engineering

    E V Shusta;P D Holler;M C Kieke;D M Kranz

  • Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency.

    Eric V Shusta;Michele C Kieke;Evan Parke;David M Kranz

  • Theoretical analysis of antibody targeting of tumor spheroids: Importance of dosage for penetration, and affinity for retention

    Christilyn P Graff;K Dane Wittrup

  • Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

    Tyrel T. Smith;Howell F. Moffett;Sirkka B. Stephan;Cary F. Opel

  • Selection of functional T cell receptor mutants from a yeast surface-display library.

    Michele C. Kieke;Eric V. Shusta;Eric T. Boder;Luc Teyton

  • Protein Disulfide Isomerase Overexpression Increases Secretion of Foreign Proteins in Saccharomyces cerevisiae

    Anne Skaja Robinson;Victoria Hines;K. Dane Wittrup

Frequent Co-Authors

Darrell J. Irvine
Darrell J. Irvine Scripps Research Institute
David M. Kranz
David M. Kranz University of Illinois at Urbana-Champaign
Oliver W. Press
Oliver W. Press University of Washington
Douglas A. Lauffenburger
Douglas A. Lauffenburger MIT
Eric V. Shusta
Eric V. Shusta University of Wisconsin–Madison
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research
Margaret E. Ackerman
Margaret E. Ackerman Dartmouth College
Antony W. Burgess
Antony W. Burgess Walter and Eliza Hall Institute of Medical Research
Terrance Grant Johns
Terrance Grant Johns Telethon Kids Institute
Jianzhu Chen
Jianzhu Chen MIT

External Links

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Best Scientists Citing K. Dane Wittrup

David M. Kranz

David M. Kranz

University of Illinois at Urbana-Champaign

Publications: 91

K. Christopher Garcia

K. Christopher Garcia

Stanford University

Publications: 48

David Baker

David Baker

University of Washington

Publications: 46

Darrell J. Irvine

Darrell J. Irvine

Scripps Research Institute

Publications: 41

Harald Kolmar

Harald Kolmar

Technical University of Darmstadt

Publications: 40

Andrew M. Scott

Andrew M. Scott

La Trobe University

Publications: 38

Andreas Plückthun

Andreas Plückthun

University of Zurich

Publications: 38

Candan Tamerler

Candan Tamerler

University of Kansas

Publications: 37

Eric V. Shusta

Eric V. Shusta

University of Wisconsin–Madison

Publications: 37

George Georgiou

George Georgiou

The University of Texas at Austin

Publications: 35

Anna Orlova

Anna Orlova

Uppsala University

Publications: 35

Vladimir Tolmachev

Vladimir Tolmachev

Uppsala University

Publications: 33

Inger Sandlie

Inger Sandlie

University of Oslo

Publications: 32

Andrew Bradbury

Andrew Bradbury

Los Alamos National Laboratory

Publications: 29

Terrance Grant Johns

Terrance Grant Johns

Telethon Kids Institute

Publications: 29

Mehmet Sarikaya

Mehmet Sarikaya

University of Washington

Publications: 28

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