World's Best Scientists 2026 revealed!
K. Christopher Garcia

K. Christopher Garcia

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
52087
World Ranking
637
National Ranking
407

Research.com Recognitions

  • 2012 - Member of the National Academy of Sciences

Overview

K. Christopher Garcia is affiliated with Stanford University in the United States and has contributed extensively to the fields of Immunology, Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Their research spans numerous subfields including Immunology, Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging, and Genetics.

The scientist's work frequently appears in several prominent publication venues, with the highest number of publications in bioRxiv (Cold Spring Harbor Laboratory). Other notable venues include Nature, Science, Cell, and eLife.

Key areas of study and main topics researched by Garcia include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • Receptor Mechanisms and Signaling
  • Cytokine Signaling Pathways and Interactions

Garcia has collaborated extensively, with frequent co-authors including Kevin M. Jude, Lora K. Picton, Leon Su, Caleb R. Glassman, and Yi Miao, reflecting ongoing partnerships contributing to the breadth of their research output.

Recent papers published include:

  • Accurate prediction of protein structures and interactions using a three-track neural network, 2021, Science
  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli, 2020, Nature
  • Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM, 2022, Nature
  • Design of protein-binding proteins from the target structure alone, 2022, Nature
  • Progenitor identification and SARS-CoV-2 infection in human distal lung organoids, 2020, Nature

Garcia was recognized in 2012 by being inducted as a Member of the National Academy of Sciences, marking a significant milestone within their academic career.

Best Publications

  • Accurate prediction of protein structures and interactions using a three-track neural network

    Minkyung Baek;Frank DiMaio;Ivan Anishchenko;Justas Dauparas

  • An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex

    K. Christopher Garcia;Massimo Degano;Robyn L. Stanfield;Anders Brunmark

  • STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

    Chan Young Park;Paul J. Hoover;Franklin M. Mullins;Priti Bachhawat

  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.

    Cayetano Pleguezuelos-Manzano;Jens Puschhof;Axel Rosendahl Huber;Arne van Hoeck

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

    Çagla Eroglu;Çagla Eroglu;Nicola J. Allen;Michael W. Susman;Nancy A. O'Rourke

  • Structural basis of Wnt recognition by Frizzled.

    Claudia Y. Janda;Deepa Waghray;Aron M. Levin;Christoph Thomas

  • Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

    Joseph A. Fraietta;Christopher L. Nobles;Morgan A. Sammons;Morgan A. Sammons;Stefan Lundh

  • Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

    K. Christopher Garcia;Massimo Degano;Larry R. Pease;Mingdong Huang

  • Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex

    Martin J. Boulanger;Dar-chone Chow;Elena E. Brevnova;K. Christopher Garcia

  • Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

    April Goehring;Chia Hsueh Lee;Kevin H. Wang;Jennifer Carlisle Michel

  • Structural basis of T cell recognition.

    Garcia Kc;Teyton L;Wilson Ia

  • Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

    Xinquan Wang;Mathias Rickert;K. Christopher Garcia

  • Deconstructing the Peptide-MHC Specificity of T Cell Recognition

    Michael E. Birnbaum;Juan L. Mendoza;Dhruv K. Sethi;Shen Dong

  • Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

    Sherry L. LaPorte;Z. Sean Juo;Jana Vaclavikova;Leremy A. Colf

  • Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

    Aron M. Levin;Darren L. Bates;Aaron M. Ring;Carsten Krieg

  • Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.

    Aaron M. Ring;Aashish Manglik;Andrew C. Kruse;Michael D. Enos

  • Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

    Kipp Weiskopf;Aaron M. Ring;Chia Chi M. Ho;Jens-Peter Volkmer

  • In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles.

    Yeteng Zhong;Zhuoran Ma;Feifei Wang;Xi Wang

  • De novo design of potent and selective mimics of IL-2 and IL-15

    Daniel-Adriano Silva;Shawn Yu;Umut Y Ulge;Jamie B Spangler;Jamie B Spangler

  • The composition and signaling of the IL-35 receptor are unconventional.

    Lauren W Collison;Greg M Delgoffe;Clifford S Guy;Kate M Vignali

Frequent Co-Authors

Aaron M. Ring
Aaron M. Ring Yale University
Mark M. Davis
Mark M. Davis Stanford University
Jacob Piehler
Jacob Piehler Osnabrück University
Luc Teyton
Luc Teyton Scripps Research Institute
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Thomas Walz
Thomas Walz Rockefeller University
David M. Kranz
David M. Kranz University of Illinois at Urbana-Champaign
Erin J. Adams
Erin J. Adams University of Chicago
Irving L. Weissman
Irving L. Weissman Stanford University
Calvin J. Kuo
Calvin J. Kuo Stanford University

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