2019 - Distinguished Scientist Award, American Heart Association
2015 - Fellow of the American Academy of Arts and Sciences
2015 - Fellow, National Academy of Inventors
2014 - Member of the National Academy of Medicine (NAM)
2013 - Member of the Royal Irish Academy
2012 - Nobel Prize for studies of G-protein-coupled receptors
2011 - Member of the National Academy of Sciences
Brian K. Kobilka spends much of his time researching Receptor, G protein-coupled receptor, Biochemistry, Protein structure and G protein. His Receptor research incorporates themes from Endocrinology, Stimulation and Signal transduction. Brian K. Kobilka combines subjects such as Agonist, Heterotrimeric G protein, Biophysics and Transmembrane protein with his study of G protein-coupled receptor.
He has researched Biophysics in several fields, including Extracellular and GTP-binding protein regulators. The various areas that Brian K. Kobilka examines in his Protein structure study include Cell signaling, Structural biology, Transmembrane domain, Conformational change and Binding site. His study in G protein is interdisciplinary in nature, drawing from both Stereochemistry and Allosteric regulation.
His scientific interests lie mostly in Receptor, G protein-coupled receptor, Biochemistry, Biophysics and Cell biology. His Receptor research is multidisciplinary, incorporating perspectives in Endocrinology and Signal transduction. He interconnects Allosteric regulation, Heterotrimeric G protein, G protein, Protein structure and Membrane protein in the investigation of issues within G protein-coupled receptor.
His Molecular biology research extends to Biochemistry, which is thematically connected. His studies deal with areas such as Ligand, Membrane, Plasma protein binding and Transmembrane protein as well as Biophysics. His research investigates the link between Adrenergic receptor and topics such as Pharmacology that cross with problems in Muscarinic acetylcholine receptor.
Brian K. Kobilka mainly investigates Biophysics, Receptor, G protein-coupled receptor, G protein and Membrane protein. His Biophysics research includes elements of Inverse agonist, Function, Allosteric regulation and Binding site. The concepts of his Receptor study are interwoven with issues in Protein structure and Cell biology.
His G protein-coupled receptor study integrates concerns from other disciplines, such as Muscarinic acetylcholine receptor, Ligand, Intracellular, Heterotrimeric G protein and Protein engineering. When carried out as part of a general G protein research project, his work on GTP-Binding Protein alpha Subunits is frequently linked to work in Coupling, therefore connecting diverse disciplines of study. His Agonist research is multidisciplinary, relying on both Signal transduction, Adrenergic and Pharmacology.
Brian K. Kobilka mostly deals with G protein-coupled receptor, Biophysics, Receptor, G protein and Membrane protein. The concepts of his G protein-coupled receptor study are interwoven with issues in Protein complex formation, Muscarinic acetylcholine receptor, Allosteric regulation and Intracellular. His Biophysics research incorporates themes from Ion, Transmembrane signaling and Optogenetics, Channelrhodopsin.
The various areas that Brian K. Kobilka examines in his Receptor study include Signal transduction, Cell biology and Binding site. Brian K. Kobilka combines subjects such as Protein structure, Protein engineering and Gene isoform with his study of G protein. His work is dedicated to discovering how Agonist, Pharmacology are connected with Mechanism of action, Salmeterol and Partial agonist and other disciplines.
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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Vadim Cherezov;Daniel M. Rosenbaum;Michael A. Hanson;Søren G. F. Rasmussen.
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Søren G. F. Rasmussen;Brian T. DeVree;Yaozhong Zou;Andrew C. Kruse.
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
Søren G F Rasmussen;Hee Jung Choi;Daniel M. Rosenbaum;Tong Sun Kobilka.
The structure and function of G-protein-coupled receptors
Daniel M. Rosenbaum;Søren G. F. Rasmussen;Brian K. Kobilka.
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Søren G F Rasmussen;Hee Jung Choi;Juan Jose Fung;Els Pardon.
Cloning of the gene and cDNA for mammalian β -adrenergic receptor and homology with rhodopsin
Richard A. F. Dixon;Brian K. Kobilka;David J. Strader;Jeffrey L. Benovic.
GPCR Engineering Yields High-Resolution Structural Insights into β2-Adrenergic Receptor Function
Daniel M. Rosenbaum;Vadim Cherezov;Michael A. Hanson;Søren G. F. Rasmussen.
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
Aashish Manglik;Andrew C. Kruse;Tong Sun Kobilka;Foon Sun Thian.
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Jonathan D. Urban;William P. Clarke;Mark Von Zastrow;David E. Nichols.
Journal of Pharmacology and Experimental Therapeutics (2007)
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity
Brian K. Kobilka;Tong Sun Kobilka;Kiefer Daniel;John W. Regan.
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