What is he best known for?
The fields of study he is best known for:
Brian K. Kobilka spends much of his time researching Receptor, G protein-coupled receptor, Biochemistry, Protein structure and G protein.
His Receptor research incorporates themes from Endocrinology, Stimulation and Signal transduction.
Brian K. Kobilka combines subjects such as Agonist, Heterotrimeric G protein, Biophysics and Transmembrane protein with his study of G protein-coupled receptor.
He has researched Biophysics in several fields, including Extracellular and GTP-binding protein regulators.
The various areas that Brian K. Kobilka examines in his Protein structure study include Cell signaling, Structural biology, Transmembrane domain, Conformational change and Binding site.
His study in G protein is interdisciplinary in nature, drawing from both Stereochemistry and Allosteric regulation.
His most cited work include:
- High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. (2718 citations)
- Crystal structure of the β2 adrenergic receptor-Gs protein complex. (2107 citations)
- Crystal structure of the human β2 adrenergic G-protein-coupled receptor (1661 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Receptor, G protein-coupled receptor, Biochemistry, Biophysics and Cell biology.
His Receptor research is multidisciplinary, incorporating perspectives in Endocrinology and Signal transduction.
He interconnects Allosteric regulation, Heterotrimeric G protein, G protein, Protein structure and Membrane protein in the investigation of issues within G protein-coupled receptor.
His Molecular biology research extends to Biochemistry, which is thematically connected.
His studies deal with areas such as Ligand, Membrane, Plasma protein binding and Transmembrane protein as well as Biophysics.
His research investigates the link between Adrenergic receptor and topics such as Pharmacology that cross with problems in Muscarinic acetylcholine receptor.
He most often published in these fields:
- Receptor (56.51%)
- G protein-coupled receptor (45.81%)
- Biochemistry (29.07%)
What were the highlights of his more recent work (between 2017-2021)?
- Biophysics (30.47%)
- Receptor (56.51%)
- G protein-coupled receptor (45.81%)
In recent papers he was focusing on the following fields of study:
Brian K. Kobilka mainly investigates Biophysics, Receptor, G protein-coupled receptor, G protein and Membrane protein.
His Biophysics research includes elements of Inverse agonist, Function, Allosteric regulation and Binding site.
The concepts of his Receptor study are interwoven with issues in Protein structure and Cell biology.
His G protein-coupled receptor study integrates concerns from other disciplines, such as Muscarinic acetylcholine receptor, Ligand, Intracellular, Heterotrimeric G protein and Protein engineering.
When carried out as part of a general G protein research project, his work on GTP-Binding Protein alpha Subunits is frequently linked to work in Coupling, therefore connecting diverse disciplines of study.
His Agonist research is multidisciplinary, relying on both Signal transduction, Adrenergic and Pharmacology.
Between 2017 and 2021, his most popular works were:
- Structure and dynamics of GPCR signaling complexes. (271 citations)
- The Molecular Basis of G Protein-Coupled Receptor Activation. (259 citations)
- Structure of the µ-opioid receptor–G i protein complex (223 citations)
In his most recent research, the most cited papers focused on:
Brian K. Kobilka mostly deals with G protein-coupled receptor, Biophysics, Receptor, G protein and Membrane protein.
The concepts of his G protein-coupled receptor study are interwoven with issues in Protein complex formation, Muscarinic acetylcholine receptor, Allosteric regulation and Intracellular.
His Biophysics research incorporates themes from Ion, Transmembrane signaling and Optogenetics, Channelrhodopsin.
The various areas that Brian K. Kobilka examines in his Receptor study include Signal transduction, Cell biology and Binding site.
Brian K. Kobilka combines subjects such as Protein structure, Protein engineering and Gene isoform with his study of G protein.
His work is dedicated to discovering how Agonist, Pharmacology are connected with Mechanism of action, Salmeterol and Partial agonist and other disciplines.
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