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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
45865
World Ranking
652
National Ranking
14

Medicine

D-Index
120
Citations
46012
World Ranking
3789
National Ranking
151

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Michel Bouvier is affiliated with the University of Montreal in Canada. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a notable focus on molecular and cellular mechanisms.

The scientist has made contributions in main fields such as:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad domains, subfields of study include:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Immunology and Allergy
  • Surgery
  • Pharmacology

Bouvier's main research topics address several aspects related to cellular signaling and physiological regulation, including:

  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology
  • Protein Kinase Regulation and GTPase Signaling
  • Computational Drug Discovery Methods
  • Pancreatic function and diabetes
  • Monoclonal and Polyclonal Antibodies Research
  • Allergic Rhinitis and Sensitization

Their recent papers include:

  • "GPCR activation mechanisms across classes and macro/microscales," 2021, published in Nature Structural & Molecular Biology
  • "Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs," 2022, published in eLife
  • "Community guidelines for GPCR ligand bias: IUPHAR review 32," 2022, published in British Journal of Pharmacology
  • "How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling," 2020, published in Cell
  • "Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling," 2021, published in Cell Reports

Bouvier has frequently published alongside several collaborators, including:

  • Christian Le Gouill
  • Franziska M. Heydenreich
  • Hiroyuki Kobayashi
  • Billy Breton
  • Charlotte Avet

Their work appears repeatedly in multiple academic venues, with publications concentrated in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Revue française de finances publiques.
  • Nature Communications
  • Revue française d'allergologie
  • ACS Pharmacology & Translational Science

Best Publications

  • Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET).

    Stephane Angers;Ali Salahpour;Eric Joly;Sandrine Hilairet

  • A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

    Terence E. Hebert;Serge Moffett;Jean-Pierre Morello;Thomas P. Loisel

  • Roles of G-protein-coupled receptor dimerization.

    Sonia Terrillon;Michel Bouvier

  • Oligomerization of G-protein-coupled transmitter receptors

    Michel Bouvier

  • Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

    B F O'Dowd;M Hnatowich;M G Caron;R J Lefkowitz

  • Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function.

    Stephane Angers;Ali Salahpour;Michel Bouvier

  • Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

    Jean-Pierre Morello;Ali Salahpour;André Laperrière;Virginie Bernier

  • β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

    Mounia Azzi;Pascale G. Charest;Stéphane Angers;Guy Rousseau

  • Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation.

    Takaaki Yoshimasa;Takaaki Yoshimasa;David R. Sibley;Michel Bouvier;Robert J. Lefkowitz

  • Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

    Jean-François Mercier;Ali Salahpour;Stéphane Angers;Andreas Breit

  • Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization.

    M Bouvier;W P Hausdorff;A De Blasi;B F O'Dowd

  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors.

    Jeffrey L. Benovic;Michel Bouvier;Marc G. Caron;Robert J. Lefkowitz

  • Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

    W P Hausdorff;M Bouvier;B F O'Dowd;G P Irons

  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

    Alex R.B. Thomsen;Bianca Plouffe;Thomas J. Cahill;Arun K. Shukla

  • Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization QUALITATIVE AND QUANTITATIVE ASSESSMENT BY FLUORESCENCE AND BIOLUMINESCENCE ENERGY TRANSFER

    Meritxell Canals;Daniel Marcellino;Francesca Fanelli;Francisco Ciruela

  • Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes

    Céline Galés;Joost J J Van Durm;Stéphane Schaak;Stéphanie Pontier

  • Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

    Sébastien Bulenger;Stefano Marullo;Michel Bouvier

  • Inverse agonist activity of beta-adrenergic antagonists.

    Peter Chidiac;Terence E. Hebert;Manon Valiquette;Michael Dennis

  • Real-time monitoring of receptor and G-protein interactions in living cells

    Céline Galés;R Victor Rebois;Mireille Hogue;Phan Trieu

  • Building a new conceptual framework for receptor heteromers

    Sergi Ferré;Ruben Baler;Michel Bouvier;Marc G. Caron

Frequent Co-Authors

Stefano Marullo
Stefano Marullo Université Paris Cité
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Terence E. Hébert
Terence E. Hébert McGill University
Stephane Angers
Stephane Angers University of Toronto
Marc G. Caron
Marc G. Caron Duke University
Daniel G. Bichet
Daniel G. Bichet University of Montreal
Martin J. Lohse
Martin J. Lohse ISAR Bioscience Institute
Brian K. Kobilka
Brian K. Kobilka Stanford University
Graeme Milligan
Graeme Milligan University of Glasgow

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