D-Index & Metrics Best Publications
Biology and Biochemistry
Spain
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 90 Citations 23,258 353 World Ranking 1065 National Ranking 8

Research.com Recognitions

Awards & Achievements

2022 - Research.com Biology and Biochemistry in Spain Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Biochemistry

Rafael Franco mostly deals with Receptor, Dopamine receptor D2, Cell biology, Adenosine and Adenosine A2A receptor. His Receptor research integrates issues from Dopamine and Pharmacology. His study in Dopamine receptor D2 is interdisciplinary in nature, drawing from both 5-HT5A receptor, Dopamine receptor and G protein-coupled receptor.

His Cell biology study integrates concerns from other disciplines, such as Endocrinology, Metabotropic glutamate receptor 6, Metabotropic glutamate receptor, Metabotropic receptor and Internal medicine. In his study, Parkinson's disease is inextricably linked to Adenosine receptor, which falls within the broad field of Adenosine. His Adenosine A2A receptor research includes themes of Neuroscience and Postsynaptic potential.

His most cited work include:

  • Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers (465 citations)
  • Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors (428 citations)
  • Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes (385 citations)

What are the main themes of his work throughout his whole career to date?

Rafael Franco mainly focuses on Receptor, Cell biology, G protein-coupled receptor, Neuroscience and Biochemistry. His study on Receptor is mostly dedicated to connecting different topics, such as Adenosine. His work deals with themes such as Adenosine A1 receptor and Stereochemistry, which intersect with Adenosine.

His work carried out in the field of Cell biology brings together such families of science as 5-HT5A receptor, Adenosine A2B receptor and Metabotropic glutamate receptor. His studies in G protein-coupled receptor integrate themes in fields like Biophysics, Allosteric regulation and G protein. The study incorporates disciplines such as Cannabinoid and Neurotransmission in addition to Neuroscience.

He most often published in these fields:

  • Receptor (52.35%)
  • Cell biology (31.23%)
  • G protein-coupled receptor (31.59%)

What were the highlights of his more recent work (between 2017-2021)?

  • Receptor (52.35%)
  • G protein-coupled receptor (31.59%)
  • Cell biology (31.23%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Receptor, G protein-coupled receptor, Cell biology, Neuroscience and Heteroreceptor. His Receptor research incorporates themes from Signal transduction and Dopamine. Rafael Franco interconnects Adenosine, Agonist, Adenosine A2A receptor, Adenosine receptor and Biophysics in the investigation of issues within G protein-coupled receptor.

His research integrates issues of Downregulation and upregulation and Receptor complex in his study of Cell biology. His research in Neuroscience focuses on subjects like Functional selectivity, which are connected to Endogenous agonist. His Cannabinoid receptor research incorporates elements of Endocannabinoid system and Pharmacology.

Between 2017 and 2021, his most popular works were:

  • Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia (50 citations)
  • Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors. (44 citations)
  • Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes. (39 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Biochemistry

His main research concerns Receptor, Cell biology, G protein-coupled receptor, Heteroreceptor and Cannabinoid receptor type 2. His Receptor research is multidisciplinary, relying on both Substantia nigra and Endocrinology, Dopamine. His work carried out in the field of G protein-coupled receptor brings together such families of science as Neuroscience and Adenosine receptor.

His study in Adenosine receptor is interdisciplinary in nature, drawing from both Potency and Adenosine. His work focuses on many connections between Cannabinoid receptor type 2 and other disciplines, such as Cannabinoid, that overlap with his field of interest in Proximity ligation assay. His Cannabinoid receptor research includes themes of Endocannabinoid system and Pharmacology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers

Francisco Ciruela;Vicent Casadó;Ricardo J. Rodrigues;Rafael Luján.
The Journal of Neuroscience (2006)

590 Citations

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

Joëlle A. Hillion;Meritxell Canals;Maria Torvinen;Vicent Casado.
Journal of Biological Chemistry (2002)

573 Citations

Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization QUALITATIVE AND QUANTITATIVE ASSESSMENT BY FLUORESCENCE AND BIOLUMINESCENCE ENERGY TRANSFER

Meritxell Canals;Daniel Marcellino;Francesca Fanelli;Francisco Ciruela.
Journal of Biological Chemistry (2003)

509 Citations

Alternatively activated microglia and macrophages in the central nervous system.

Rafael Franco;Diana Fernández-Suárez.
Progress in Neurobiology (2015)

504 Citations

Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes

Silvia Ginés;Joëlle Hillion;Maria Torvinen;Stèphane Le Crom.
Proceedings of the National Academy of Sciences of the United States of America (2000)

502 Citations

Building a new conceptual framework for receptor heteromers

Sergi Ferré;Ruben Baler;Michel Bouvier;Marc G. Caron.
Nature Chemical Biology (2009)

411 Citations

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

Sergi Ferré;Marzena Karcz-Kubicha;Bruce T. Hope;Patrizia Popoli.
Proceedings of the National Academy of Sciences of the United States of America (2002)

409 Citations

Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

Luigi F. Agnati;Sergi Ferré;Carme Lluis;Rafael Franco.
Pharmacological Reviews (2003)

392 Citations

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

Paulina Carriba;Gemma Navarro;Francisco Ciruela;Sergi Ferré.
Nature Methods (2008)

331 Citations

Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function.

Kjell Fuxe;Sergi Ferré;Susanna Genedani;Rafael Franco.
Physiology & Behavior (2007)

304 Citations

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