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Biology and Biochemistry

D-Index
65
Citations
15183
World Ranking
9146
National Ranking
4060

Overview

Alyssa H. Hasty is affiliated with Vanderbilt University in the United States and conducts research primarily in the fields of Medicine and Immunology and Microbiology. Their specialization spans several subfields, including Immunology, Physiology, Epidemiology, Genetics, and Molecular Biology.

Their work addresses a range of topics with a focus on the intersection of immune function and metabolic processes. Key research topics include:

  • Adipokines, Inflammation, and Metabolic Diseases
  • Immune Cell Function and Interaction
  • Adipose Tissue and Metabolism
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Iron Metabolism and Disorders
  • Dietary Effects on Health

Recent papers authored by or including Alyssa H. Hasty demonstrate a concentration on immune-related metabolic regulation and tissue-specific immune responses. Notable publications include:

  • Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice, 2022, Nature Communications
  • Regulation of tissue iron homeostasis: the macrophage "ferrostat", 2020, JCI Insight
  • Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair, 2022, Science Translational Medicine
  • Adipose tissue macrophages: Unique polarization and bioenergetics in obesity, 2020, Immunological Reviews
  • Metaflammation in obesity and its therapeutic targeting, 2023, Science Translational Medicine

The researcher has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Science Translational Medicine, Nature, Frontiers in Immunology, and the American Journal of Physiology-Endocrinology and Metabolism. These locations reflect a broad interest in translational and fundamental biomedical research.

Collaborations with other scientists are also a significant aspect of their work. Frequent co-authors include:

  • Matthew A. Cottam
  • Nathan C. Winn
  • Heather L. Caslin
  • Jamie N. Garcia
  • Elysa W. Pierro

This body of work contributes to understanding the immune system's role in metabolism, obesity-related inflammation, and tissue repair. The integration of multiomics approaches and focus on macrophage biology underline the multidisciplinary nature of their research activities.

Best Publications

  • Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

    Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo;Alyssa H. Hasty

  • Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

    Tomohiro Yoshikawa;Hitoshi Shimano;Michiyo Amemiya-Kudo;Naoya Yahagi

  • Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

    Michiyo Amemiya-Kudo;Hitoshi Shimano;Alyssa H. Hasty;Naoya Yahagi

  • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Takashi Matsuzaka

  • A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Michiyo Amemiya-Kudo

  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

    Tomohiro Yoshikawa;Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi

  • Macrophage infiltration into adipose tissue: initiation, propagation and remodeling

    Bonnie K Surmi;Alyssa H Hasty

  • Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

    Sergio Fazio;Vladimir R. Babaev;Alisa B. Murray;Alyssa H. Hasty

  • Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic β-Cell Dysfunction

    Mingming Hao;W. Steven Head;Subhadra C. Gunawardana;Alyssa H. Hasty

  • Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo

  • Mouse models of the metabolic syndrome

    Arion J. Kennedy;Kate L. J. Ellacott;Victoria L. King;Alyssa H. Hasty

  • Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene*

    Michiyo Amemiya-Kudo;Hitoshi Shimano;Tomohiro Yoshikawa;Naoya Yahagi

  • Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor *

    Alyssa H. Hasty;Hitoshi Shimano;Jun-ichi Osuga;Ichiji Namatame

  • Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia.

    Dario A. Gutierrez;Michael J. Puglisi;Alyssa H. Hasty

  • Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Tomohiro Yoshikawa

  • A decade of progress in adipose tissue macrophage biology

    Andrea A. Hill;W. Reid Bolus;Alyssa H. Hasty

  • Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

    Toyonori Kato;Hitoshi Shimano;Takashi Yamamoto;Mayumi Ishikawa

  • Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo

  • Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis

    Marnie Lorn Gruen;Mingming Hao;David Piston;Alyssa H Hasty

  • Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system.

    Laura B. Buckman;Alyssa H. Hasty;David K. Flaherty;Christopher T. Buckman

Frequent Co-Authors

Naoya Yahagi
Naoya Yahagi University of Tsukuba
MacRae F. Linton
MacRae F. Linton Vanderbilt University
Hitoshi Shimano
Hitoshi Shimano University of Tsukuba
Sergio Fazio
Sergio Fazio Oregon Health & Science University
Nobuhiro Yamada
Nobuhiro Yamada University of Tsukuba
Shun Ishibashi
Shun Ishibashi Jichi Medical University
Hirohito Sone
Hirohito Sone Niigata University
Takanari Gotoda
Takanari Gotoda Kyorin University
Takashi Yamamoto
Takashi Yamamoto Hiroshima University
David H. Wasserman
David H. Wasserman Vanderbilt University

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