World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
123
Citations
71932
World Ranking
544
National Ranking
345

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Bruce A. Freeman is affiliated with the University of Pittsburgh in the United States. Their research spans multiple areas within medicine and biochemistry. They have contributed extensively in the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on key subfields including Molecular Biology, Physiology, Immunology, Biochemistry, and Oncology.

The scientist's main research topics include:

  • Eicosanoids and Hypertension Pharmacology
  • Fatty Acid Research and Health
  • Peroxisome Proliferator-Activated Receptors
  • Epigenetics and DNA Methylation
  • DNA Repair Mechanisms
  • Asthma and respiratory diseases
  • Cardiovascular Function and Risk Factors

Frequent co-authors collaborating with Bruce A. Freeman are:

  • Francisco J. Schöpfer
  • Steven R. Woodcock
  • Sonia R. Salvatore
  • Stacy G. Wendell
  • Crystal Uvalle

The scientist has published multiple papers in prominent journals, with regular appearances in venues such as Free Radical Biology and Medicine, Redox Biology, bioRxiv, Nature Communications, and Scientific Reports.

Some recent publications include:

  • "Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages" (2020, Redox Biology)
  • "Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples" (2023, Nature Communications)
  • "Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane" (2020, The Journal of Nutritional Biochemistry)
  • "Electrophilic characteristics and aqueous behavior of fatty acid nitroalkenes" (2020, Redox Biology)
  • "Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma" (2021, Scientific Reports)

Bruce A. Freeman has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2012.

Best Publications

  • Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

    Joseph S. Beckman;Tanya W. Beckman;Jun Chen;Patricia A. Marshall

  • Biology of disease: free radicals and tissue injury.

    B A Freeman;J D Crapo

  • Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.

    R Radi;J S Beckman;K M Bush;B A Freeman

  • Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

    S Rajagopalan;S Kurz;T Münzel;M Tarpey

  • Peroxynitrite-induced membrane lipid peroxidation : the cytotoxic potential of superoxide and nitric oxide

    Rafael Radi;Joseph S. Beckman;Kenneth M. Bush;Bruce A. Freeman

  • Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

    Jason P. Eiserich;Jason P. Eiserich;Milena Hristova;Carroll E. Cross;A. Daniel Jones

  • Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.

    H Rubbo;R Radi;M Trujillo;R Telleri

  • Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

    Jørn Bech Laursen;Sanjay Rajagopalan;Zorina Galis;Margaret Tarpey

  • Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.

    B A Freeman;J D Crapo

  • Superoxide and peroxynitrite in atherosclerosis.

    C R White;T A Brock;L Y Chang;J Crapo

  • Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

    Jørn Bech Laursen;Mark Somers;Sabine Kurz;Louise McCann

  • Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

    Jason P. Eiserich;Stephan Baldus;Marie Luise Brennan;Wenxin Ma

  • Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

    T Münzel;H Sayegh;B A Freeman;M M Tarpey

  • Nitrate and nitrite in biology, nutrition and therapeutics

    Jon O Lundberg;Mark T Gladwin;Amrita Ahluwalia;Nigel Benjamin

  • Detection of catalase in rat heart mitochondria.

    R. Radi;J. F. Turrens;Ling Yi Chang;K. M. Bush

  • The emerging biology of the nitrite anion

    Mark T Gladwin;Alan N Schechter;Daniel B Kim-Shapiro;Rakesh P Patel

  • Peroxynitrite Reaction with Carbon Dioxide/Bicarbonate: Kinetics and Influence on Peroxynitrite-Mediated Oxidations

    Ana Denicola;Bruce A. Freeman;Madia Trujillo;Rafael Radi

  • Biological aspects of reactive nitrogen species.

    Rakesh P. Patel;Joanne McAndrew;Hassan Sellak;C.Roger White

  • Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

    J F Turrens;J D Crapo;B A Freeman

  • Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

    Tsung H. Liu;Joseph S. Beckman;Bruce A. Freeman;Edward L. Hogan

Frequent Co-Authors

Francisco J. Schopfer
Francisco J. Schopfer University of Pittsburgh
Rafael Radi
Rafael Radi University of the Republic
Valerie B. O'Donnell
Valerie B. O'Donnell Cardiff University
Stephan Baldus
Stephan Baldus University of Cologne
Joseph S. Beckman
Joseph S. Beckman Oregon State University
Y. Eugene Chen
Y. Eugene Chen University of Michigan–Ann Arbor
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Jifeng Zhang
Jifeng Zhang University of Michigan–Ann Arbor
Mark T. Gladwin
Mark T. Gladwin University of Pittsburgh
Sadis Matalon
Sadis Matalon University of Alabama at Birmingham

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