World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
118
Citations
62613
World Ranking
693
National Ranking
438

Medicine

D-Index
120
Citations
64015
World Ranking
3697
National Ranking
2036

Overview

Jay L. Zweier is affiliated with The Ohio State University in the United States. Their research spans fields including Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a focus on subfields such as Physiology, Molecular Biology, Neurology, Biophysics, and Cell Biology.

Their work often addresses topics including Electron Spin Resonance Studies, Nitric Oxide and Endothelin Effects, Calcium Signaling and Nucleotide Metabolism, Hemoglobin Structure and Function, Heme Oxygenase-1 and Carbon Monoxide, Neurological Disease Mechanisms and Treatments, and Receptor Mechanisms and Signaling.

Zweier has frequently published in venues such as Stroke, The FASEB Journal, American Journal of Physiology-Heart and Circulatory Physiology, Free Radical Biology and Medicine, and Journal of Biological Chemistry.

Frequent collaborators of Jay L. Zweier include Mohamed G. Ewees, Yousef Hannawi, Mohamed Elmahdy, Elsayed M. Mahgoup, and Mahmoud S. Eid.

Recent notable publications include:

  • In Situ EPR Spin Trapping and Competition Kinetics Demonstrate Temperature-Dependent Mechanisms of Synergistic Radical Production by Ultrasonically Activated Persulfate, 2022, Environmental Science & Technology
  • Long-term Electronic Cigarette Exposure Induces Cardiovascular Dysfunction Similar to Tobacco Cigarettes: Role of Nicotine and Exposure Duration, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Electronic Cigarette Exposure Causes Vascular Endothelial Dysfunction Due to NADPH Oxidase Activation and eNOS Uncoupling, 2022, American Journal of Physiology-Heart and Circulatory Physiology
  • Synergistic, Aqueous PAH Degradation by Ultrasonically-Activated Persulfate Depends on Bulk Temperature and Physicochemical Parameters, 2020, Ultrasonics Sonochemistry
  • Chronic Cigarette Smoke Exposure Triggers a Vicious Cycle of Leukocyte and Endothelial-Mediated Oxidant Stress That Results in Vascular Dysfunction, 2020, American Journal of Physiology-Heart and Circulatory Physiology

Best Publications

  • A model for p53-induced apoptosis

    Kornelia Polyak;Kornelia Polyak;Yong Xia;Jay L. Zweier;Kenneth W. Kinzler

  • Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

    Kaikobad Irani;Yong Xia;Jay L. Zweier;Steven J. Sollott

  • Reactive Oxygen Species (Ros-Induced) Ros Release: A New Phenomenon Accompanying Induction of the Mitochondrial Permeability Transition in Cardiac Myocytes

    Dmitry B. Zorov;Charles R. Filburn;Lars Oliver Klotz;Jay L. Zweier

  • Direct measurement of free radical generation following reperfusion of ischemic myocardium

    J L Zweier;J T Flaherty;M L Weisfeldt

  • The natural polyamine spermine functions directly as a free radical scavenger

    Hyo Chol Ha;Nilantha S. Sirisoma;Periannan Kuppusamy;Jay L. Zweier

  • Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process

    Yong Xia;Ah-Lim Tsai;Vladimir Berka;Jay L. Zweier

  • The role of oxidants and free radicals in reperfusion injury

    Jay L Zweier;M A Hassan Talukder

  • Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

    Yong Xia;Jay L. Zweier

  • Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

    J L Zweier

  • Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury

    Yong Xia;Valina L. Dawson;Ted M. Dawson;Solomon H. Snyder

  • Nitrate and nitrite in biology, nutrition and therapeutics

    Jon O Lundberg;Mark T Gladwin;Amrita Ahluwalia;Nigel Benjamin

  • Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.

    Periannan Kuppusamy;Haiquan Li;Govindasamy Ilangovan;Arturo J. Cardounel

  • Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia-Reperfusion Injury

    Zheqing Cai;Dominador J. Manalo;Guo Wei;E. Rene Rodriguez

  • Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues

    Jay L. Zweier;Periannan Kuppusamy;Gerard A. Lutty

  • MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

    Stephen Y. Chan;Ying Yi Zhang;Ying Yi Zhang;Craig Hemann;Christopher E. Mahoney;Christopher E. Mahoney

  • Cardiac Mitochondria and Reactive Oxygen Species Generation

    Yeong Renn Chen;Jay L. Zweier

  • Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.

    G Ambrosio;J L Zweier;C Duilio;P Kuppusamy

  • A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

    Daniela Salvemini;Zhi Qiang Wang;Jay L. Zweier;Alexandre Samouilov

  • Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems*

    Yunbo Li;Hong Zhu;Periannan Kuppusamy;Valerie Roubaud

  • A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal.

    Y. Amy Lam;T. Glen Lawson;Murugesan Velayutham;Jay L. Zweier

Frequent Co-Authors

Periannan Kuppusamy
Periannan Kuppusamy The Ohio State University
Frederick A. Villamena
Frederick A. Villamena The Ohio State University
Xiaoping Liu
Xiaoping Liu Sun Yat-sen University
Giuseppe Ambrosio
Giuseppe Ambrosio University of Perugia
Christopher M. Hadad
Christopher M. Hadad The Ohio State University
Michael A. Trush
Michael A. Trush Johns Hopkins University
Chandan K. Sen
Chandan K. Sen University of Pittsburgh
Antal Rockenbauer
Antal Rockenbauer Hungarian Academy of Sciences
Muthu Periasamy
Muthu Periasamy The Ohio State University
Lewis C. Becker
Lewis C. Becker Johns Hopkins University School of Medicine

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