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Biology and Biochemistry

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84
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Medicine

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Overview

Muthu Periasamy is affiliated with The Ohio State University in the United States. Their research spans multiple domains within medicine and biochemistry, genetics, and molecular biology, with a focus on physiology and molecular biology in particular.

The scientist's recent publications cover topics related to muscle thermogenesis, metabolic regulation, and cellular signaling mechanisms. Notable papers include:

  • "Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis" (2020, Philosophical Transactions of the Royal Society B Biological Sciences)
  • "Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations" (2020, Endocrinology and Metabolism)
  • "Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?" (2021, Frontiers in Physiology)
  • "Disruption of Dopamine Receptor 1 Localization to Primary Cilia Impairs Signaling in Striatal Neurons" (2022, Journal of Neuroscience)
  • "Structural basis for sarcolipin's regulation of muscle thermogenesis by the sarcoplasmic reticulum Ca 2+ -ATPase" (2021, Science Advances)

Periasamy has collaborated frequently with a number of researchers, including:

  • Naresh C. Bal
  • Rachel Williams
  • Dylan C. Sarver
  • Cheng Xu
  • Susana Rodriguez

The scientist's publications have appeared in diverse venues such as:

  • Philosophical Transactions of the Royal Society B Biological Sciences
  • Endocrinology and Metabolism
  • Frontiers in Physiology
  • Journal of Neuroscience
  • Science Advances

Their primary fields of study include medicine and biochemistry, genetics, and molecular biology. Within these broader areas, subfields such as physiology, molecular biology, genetics, surgery, and epidemiology have been prominent in their research output.

Key research topics addressed by Periasamy encompass:

  • Adipose Tissue and Metabolism
  • Mitochondrial Function and Pathology
  • Pancreatic function and diabetes
  • Metabolism, Diabetes, and Cancer
  • Nutrition and Health in Aging
  • Bat Biology and Ecology Studies
  • Physiological and biochemical adaptations

Best Publications

  • SERCA pump isoforms: their role in calcium transport and disease.

    Muthu Periasamy;Anuradha Kalyanasundaram

  • Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.

    M Arai;N R Alpert;D H MacLennan;P Barton

  • Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

    Naresh C Bal;Santosh K Maurya;Danesh H Sopariwala;Sanjaya K Sahoo

  • Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.

    M Arai;H Matsui;M Periasamy

  • Differential regulation of antioxidant enzymes in response to oxidants.

    S. Shull;N.H. Heintz;M. Periasamy;M. Manohar

  • Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.

    Joseph M. Miano;Peter Cserjesi;Keith L. Ligon;Muthu Periasamy

  • Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.

    M Aikawa;P N Sivam;M Kuro-o;K Kimura

  • Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature

    D F Wieczorek;M Periasamy;G S Butler-Browne;R G Whalen

  • SERCA Pump Level is a Critical Determinant of Ca2+Homeostasis and Cardiac Contractility

    Muthu Periasamy;Sabine Huke

  • Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene. Evidence against intron-dependent evolution of the rod.

    Emanuel E. Strehler;Emanuel E. Strehler;Marie Antoinette Strehler-Page;Marie Antoinette Strehler-Page;Jean Claude Perriard;Jean Claude Perriard;Muthu Periasamy;Muthu Periasamy

  • Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene

    Muthu Periasamy;Thomas D. Reed;Lynne H. Liu;Yong Ji

  • Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis

    R Nagai;M Kuro-o;P Babij;M Periasamy

  • Molecular characterization of two myosin heavy chain genes expressed in the adult heart

    V. Mahdavi;V. Mahdavi;M. Periasamy;M. Periasamy;B. Nadal-Ginard;B. Nadal-Ginard

  • Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

    M Periasamy;E E Strehler;L I Garfinkel;R M Gubits

  • Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

    Ryozo Nagai;Angel Zarain-Herzberg;Christopher J. Brandl;Junichi Fujii

  • Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology

    Muthu Periasamy;Poornima Bhupathy;Gopal J Babu

  • Troponin I gene expression during human cardiac development and in end-stage heart failure.

    S. Sasse;N. J. Brand;P. Kyprianou;G. K. Dhoot

  • Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

    M. Sulaiman;M. J. Matta;N. R. Sunderesan;M. P. Gupta

  • Targeted Overexpression of the Sarcoplasmic Reticulum Ca2+-ATPase Increases Cardiac Contractility in Transgenic Mouse Hearts

    Debra L. Baker;Katsuji Hashimoto;Ingrid L. Grupp;Yong Ji

  • Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.

    M Arai;K Otsu;D H MacLennan;N R Alpert

Frequent Co-Authors

Subash C. Gupta
Subash C. Gupta Banaras Hindu University
Jay L. Zweier
Jay L. Zweier The Ohio State University
David H. MacLennan
David H. MacLennan University of Toronto
Gary E. Shull
Gary E. Shull University of Cincinnati Medical Center
John N. Lorenz
John N. Lorenz University of Cincinnati Medical Center
Sanjay Rajagopalan
Sanjay Rajagopalan Case Western Reserve University
Eric N. Olson
Eric N. Olson The University of Texas Southwestern Medical Center
Frank Wuytack
Frank Wuytack KU Leuven
Jeffery D. Molkentin
Jeffery D. Molkentin Cincinnati Children's Hospital Medical Center
Paul J.R. Barton
Paul J.R. Barton Imperial College London

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