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Biology and Biochemistry
USA
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
155
Citations
90685
World Ranking
150
National Ranking
106

Medicine

D-Index
157
Citations
91348
World Ranking
885
National Ranking
503

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Distinguished Scientist Award, American Heart Association

Overview

Jeffery D. Molkentin is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research spans multiple fields within medicine and biochemistry, genetics, and molecular biology, with a strong focus on subfields including molecular biology, cardiology and cardiovascular medicine, surgery, physiology, and cell biology.

The scientist's work covers several main topics, notably:

  • Cardiac Fibrosis and Remodeling
  • Signaling Pathways in Disease
  • Mitochondrial Function and Pathology
  • Cardiomyopathy and Myosin Studies
  • Tissue Engineering and Regenerative Medicine
  • Adipose Tissue and Metabolism
  • Congenital Heart Defects Research

Recent scholarly publications include:

  • "Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy," 2021, Nature Communications
  • "Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes," 2020, Circulation Research
  • "A 20/20 view of ANT function in mitochondrial biology and necrotic cell death," 2020, Journal of Molecular and Cellular Cardiology
  • "Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation," 2020, Nature Communications
  • "Ca 2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons," 2022, Science Advances

Molkentin has frequently collaborated with the following coauthors:

  • Michelle A. Sargent (16 publications)
  • Ronald J. Vagnozzi (14 publications)
  • Allen J. York (14 publications)
  • Kelly M. Grimes (12 publications)
  • Yasuhide Kuwabara (11 publications)

The scientist's most common publication venues include:

  • Circulation Research (9 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Circulation (6 publications)
  • Journal of Molecular and Cellular Cardiology Plus (5 publications)
  • Nature Communications (3 publications)

In recognition of their work, Jeffery D. Molkentin received the Distinguished Scientist Award from the American Heart Association in 2020.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

    Jeffery D. Molkentin;Jeffery D. Molkentin;Jian Rong Lu;Christopher L. Antos;Bruce Markham

  • Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

    Christopher P. Baines;Robert A. Kaiser;Nicole H. Purcell;N. Scott Blair

  • Regulation of cardiac hypertrophy by intracellular signalling pathways

    Joerg Heineke;Jeffery D. Molkentin

  • Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

    Jeffery D. Molkentin;Qing Lin;Stephen A. Duncan;Eric N. Olson

  • Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.

    Christopher P. Baines;Robert A. Kaiser;Tatiana Sheiko;William J. Craigen

  • The zinc finger-containing transcription factors GATA-4, -5, and -6: Ubiquitously expressed regulators of tissue-specific gene expression

    Jeffery D. Molkentin

  • Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

    Heng Du;Lan Guo;Fang Fang;Doris Chen

  • Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

    Jeffery D. Molkentin;Brian L. Black;James F. Martin;Eric N. Olson

  • The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.

    Orlando F. Bueno;Leon J. De Windt;Kevin M. Tymitz;Sandra A. Witt

  • Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy

    Benjamin J. Wilkins;Yan-Shan Dai;Orlando F. Bueno;Stephanie A. Parsons

  • Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy

    Jeffery D Molkentin;Gerald W Dorn

  • Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

    Patrick C H Hsieh;Vincent F M Segers;Michael E Davis;Catherine MacGillivray

  • The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury

    Tibor Kempf;Matthias Eden;Jens Strelau;Marian Naguib

  • Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein

    Dawinder S. Sohal;Mai Nghiem;Michael A. Crackower;Sandra A. Witt

  • Genetic lineage tracing defines myofibroblast origin and function in the injured heart

    Onur Kanisicak;Hadi Khalil;Malina J. Ivey;Jason Karch

  • Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

    Hadi Khalil;Onur Kanisicak;Vikram Prasad;Robert N. Correll

  • PKC-alpha regulates cardiac contractility and propensity toward heart failure.

    Julian C Braz;Kimberly Gregory;Anand Pathak;Wen Zhao

  • Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

    Russell A. Norris;Brook Damon;Vladimir Mironov;Vladimir Kasyanov

  • c-kit + cells minimally contribute cardiomyocytes to the heart

    Jop H. Van Berlo;Onur Kanisicak;Marjorie Maillet;Ronald J. Vagnozzi

Frequent Co-Authors

Steven R. Houser
Steven R. Houser Temple University
Jeffrey Robbins
Jeffrey Robbins Cincinnati Children's Hospital Medical Center
John N. Lorenz
John N. Lorenz University of Cincinnati Medical Center
Bruce J. Aronow
Bruce J. Aronow Cincinnati Children's Hospital Medical Center
Eric N. Olson
Eric N. Olson The University of Texas Southwestern Medical Center
John W. Elrod
John W. Elrod Temple University
Donald M. Bers
Donald M. Bers University of California, Davis
Christopher P. Baines
Christopher P. Baines University of Missouri
Elizabeth M. McNally
Elizabeth M. McNally Northwestern University
Erhe Gao
Erhe Gao Temple University

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