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Medicine

D-Index
97
Citations
31926
World Ranking
9346
National Ranking
4820

Research.com Recognitions

  • 2009 - Distinguished Scientist Award, American Heart Association

Overview

Evangelia G. Kranias is affiliated with the University of Cincinnati Medical Center in the United States and has contributed extensively to research in the fields of medicine and biochemistry, genetics, and molecular biology. Their work primarily focuses on cardiology and cardiovascular medicine, with significant contributions to molecular biology and genetics as subfields.

The research topics that Evangelia G. Kranias has explored include:

  • Cardiomyopathy and Myosin Studies
  • Cardiac electrophysiology and arrhythmias
  • Cardiovascular Effects of Exercise
  • CRISPR and Genetic Engineering
  • Cardiac pacing and defibrillation studies
  • Ion channel regulation and function
  • Viral Infections and Immunology Research

Some of their recent publications include:

  • "Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact," 2022, Cardiovascular Research
  • "Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis," 2020, Journal of Biological Chemistry
  • "Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation," 2021, Circulation
  • "Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis," 2022, International Journal of Molecular Sciences
  • "Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias," 2021, Journal of Personalized Medicine

Frequent coauthors with whom they have collaborated include:

  • Roger J. Hajjar
  • Despina Sanoudou
  • Kobra Haghighi
  • Francesca Stillitano
  • Elizabeth Vafiadaki

Evangelia G. Kranias publishes regularly in several scientific venues with the most frequent being:

  • Circulation Research
  • Journal of Biological Chemistry
  • International Journal of Molecular Sciences
  • Cardiovascular Research
  • UNC Libraries

Their work has been recognized with the Distinguished Scientist Award from the American Heart Association in 2009.

Best Publications

  • Phospholamban: a crucial regulator of cardiac contractility

    David H. MacLennan;Evangelia G. Kranias

  • Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

    Wusheng Luo;Ingrid L. Grupp;Judy Harrer;Sathivel Ponniah

  • Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.

    Joachim P. Schmitt;Mitsuhiro Kamisago;Mitsuhiro Kamisago;Michio Asahi;Guo Hua Li

  • PKC-alpha regulates cardiac contractility and propensity toward heart failure.

    Julian C Braz;Kimberly Gregory;Anand Pathak;Wen Zhao

  • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.

    Susumu Minamisawa;Masahiko Hoshijima;Guoxiang Chu;Christopher A Ward

  • Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

    Evangelia G. Kranias;Roger J. Hajjar

  • Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

    Kobra Haghighi;Fotis Kolokathis;Luke Pater;Roy A. Lynch

  • Fibroblast growth factor 2 control of vascular tone.

    Ming Zhou;Roy L. Sutliff;Richard J. Paul;John N. Lorenz

  • The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin.

    S P Robertson;J D Johnson;M J Holroyde;E G Kranias

  • Phospholamban: A Prominent Regulator of Myocardial Contractility

    Kimberly L. Koss;Evangelia G. Kranias

  • A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy

    Kobra Haghighi;Fotis Kolokathis;Anthony O. Gramolini;Jason R. Waggoner

  • Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

    V J Kadambi;S Ponniah;J M Harrer;B D Hoit

  • Protein Kinase A Phosphorylation of the Ryanodine Receptor Does Not Affect Calcium Sparks in Mouse Ventricular Myocytes

    Yanxia Li;Evangelia G. Kranias;Gregory A. Mignery;Donald M. Bers

  • Thyroid hormone-induced alterations in phospholamban protein expression. Regulatory effects on sarcoplasmic reticulum Ca2+ transport and myocardial relaxation.

    E Kiss;G Jakab;E G Kranias;I Edes

  • Effects of Levosimendan, a Cardiotonic Agent Targeted to Troponin C, on Cardiac Function and on Phosphorylation and Ca2+ Sensitivity of Cardiac Myofibrils and Sarcoplasmic Reticulum in Guinea Pig Heart

    Istvan Edes;Eva Kiss;Yoshimi Kitada;Frances M. Powers

  • Type 1 Phosphatase, a Negative Regulator of Cardiac Function

    Andrew N. Carr;Albrecht G. Schmidt;Yoichi Suzuki;Federica Del Monte

  • Phosphorylation of phospholamban and troponin I in β-adrenergic-induced acceleration of cardiac relaxation

    Li Li;Jaime Desantiago;Guoxiang Chu;Evangelia G. Kranias

  • Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects

    Li Li;Guoxiang Chu;Evangelia G. Kranias;Donald M. Bers

  • Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

    E. G. Kranias;R. J. Solaro

  • Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

    Y. Takeishi;G. Chu;H. Wakasaki;B. D. Hoit

Frequent Co-Authors

Roger J. Hajjar
Roger J. Hajjar Icahn School of Medicine at Mount Sinai
Donald M. Bers
Donald M. Bers University of California, Davis
Gerald W. Dorn
Gerald W. Dorn Washington University in St. Louis
John N. Lorenz
John N. Lorenz University of Cincinnati Medical Center
Arnold Schwartz
Arnold Schwartz University of Cincinnati
David H. MacLennan
David H. MacLennan University of Toronto
Jeffery D. Molkentin
Jeffery D. Molkentin Cincinnati Children's Hospital Medical Center
Jeffrey Robbins
Jeffrey Robbins Cincinnati Children's Hospital Medical Center
Dimitrios Th. Kremastinos
Dimitrios Th. Kremastinos National and Kapodistrian University of Athens
Yigang Wang
Yigang Wang University of Cincinnati

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