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D-Index
87
Citations
27742
World Ranking
13645
National Ranking
6932

Overview

Xander H.T. Wehrens is affiliated with Baylor College of Medicine in the United States. Their research spans medicine and biochemistry, genetics, and molecular biology, with significant contributions to cardiology and cardiovascular medicine, molecular biology, cellular and molecular neuroscience, genetics, and immunology.

The primary focus of Wehrens' research centers around cardiac electrophysiology and arrhythmias, ion channel regulation and function, atrial fibrillation management and outcomes, cardiomyopathy and myosin studies, cardiovascular effects of exercise, cardiac arrhythmias and treatments, and cardiac fibrosis and remodeling.

They have published prolifically in several scientific journals, with frequent contributions to these venues:

  • Circulation Research
  • Heart Rhythm
  • Circulation
  • Cardiovascular Research
  • Cardiovascular Drugs and Therapy

Among Wehrens' recent papers are:

  • Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation, 2020, Circulation Research
  • Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia, 2020, Nature
  • Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy, 2020, Journal of Clinical Investigation
  • Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation, 2020, Circulation
  • Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms, 2020, Journal of Clinical Investigation

The work is often collaborative, and their frequent co-authors include:

  • Satadru K. Lahiri
  • Mohit Hulsurkar
  • Joshua A. Keefe
  • Yuriana Aguilar-Sánchez
  • Dobromir Dobrev

Wehrens has focused on advancing the understanding of atrial fibrillation and cardiac arrhythmias through molecular and physiological investigations. Their studies contribute extensively to mechanisms of ion channel behavior, myocardial fibrosis, and cardiomyopathy, reflecting a multidisciplinary approach combining clinical and molecular research.

Best Publications

  • Correction: Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases

    Yuejin Wu;Tyler P. Rasmussen;Olha M. Koval;Mei-ling A. Joiner

  • FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death

    Xander H T Wehrens;Stephan E. Lehnart;Fannie Huang;John A. Vest

  • Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor

    Xander H.T. Wehrens;Stephan E. Lehnart;Steven R. Reiken;Andrew R. Marks

  • Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction

    Sameer Ather;Wenyaw Chan;Biykem Bozkurt;Biykem Bozkurt;David Aguilar

  • Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

    Niels Voigt;Na Li;Qiongling Wang;Wei Wang

  • Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

    Stephan E. Lehnart;Xander H.T. Wehrens;Steven Reiken;Sunita Warrier

  • Protection from Cardiac Arrhythmia Through Ryanodine Receptor- Stabilizing Protein Calstabin2

    Xander H. T. Wehrens;Stephan E. Lehnart;Steven R. Reiken;Shi-Xian Deng

  • Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.

    Chunxia Yao;Tina Veleva;Larry Scott;Shuyi Cao

  • Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

    Niels Voigt;Jordi Heijman;Qiongling Wang;David Y. Chiang

  • Calcium Signaling and Cardiac Arrhythmias.

    Andrew P. Landstrom;Dobromir Dobrev;Xander H.T. Wehrens

  • Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

    Mihail G. Chelu;Mihail G. Chelu;Satyam Sarma;Subeena Sood;Sufen Wang;Sufen Wang

  • INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE

    Xander H T Wehrens;Stephan E Lehnart;Andrew R Marks

  • Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

    Xander H. T. Wehrens;Stephan E. Lehnart;Steven Reiken;John A. Vest

  • Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation

    John A. Vest;Xander H.T. Wehrens;Steven R. Reiken;Stephan E. Lehnart

  • β-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure

    Steven Reiken;Xander H.T. Wehrens;John A. Vest;Alessandro Barbone

  • Circadian rhythms govern cardiac repolarization and arrhythmogenesis

    Darwin Jeyaraj;Saptarsi M. Haldar;Xiaoping Wan;Mark D. McCauley

  • Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated With Calcium Release Channel (Ryanodine Receptor) Leak

    Stephan E. Lehnart;Xander H.T. Wehrens;Päivi J. Laitinen;Steven R. Reiken

  • Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure

    Ralph J. van Oort;Mark D. McCauley;Sayali S. Dixit;Laetitia Pereira

  • Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

    Jun Wang;Elzbieta Klysik;Subeena Sood;Randy L. Johnson

  • Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.

    Anil Purohit;Adam G. Rokita;Xiaoqun Guan;Biyi Chen

Frequent Co-Authors

Dobromir Dobrev
Dobromir Dobrev University of Duisburg-Essen
Mark E. Anderson
Mark E. Anderson Johns Hopkins University
Andrew R. Marks
Andrew R. Marks Columbia University
Stanley Nattel
Stanley Nattel Montreal Heart Institute
James F. Martin
James F. Martin Baylor College of Medicine
Donald M. Bers
Donald M. Bers University of California, Davis
Ursula Ravens
Ursula Ravens University of Freiburg
Peter J. Mohler
Peter J. Mohler The Ohio State University
Thomas A. Cooper
Thomas A. Cooper Baylor College of Medicine

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