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Rodolphe Fischmeister

Rodolphe Fischmeister

D-Index & Metrics

Medicine

D-Index
77
Citations
16388
World Ranking
18587
National Ranking
618

Research.com Recognitions

  • 2007 - Member of Academia Europaea

Overview

Rodolphe Fischmeister is affiliated with the University of Paris-Saclay in France. Their research primarily focuses on medicine and biochemistry, genetics and molecular biology, with a significant emphasis on molecular biology and cardiology and cardiovascular medicine.

The scientist's work explores a variety of main topics including phosphodiesterase function and regulation, cardiac electrophysiology and arrhythmias, heart failure treatment and management, receptor mechanisms and signaling, ion channel regulation and function, nitric oxide and endothelin effects, as well as chemotherapy-induced cardiotoxicity and its mitigation.

Rodolphe Fischmeister has published extensively, with notable papers such as:

  • Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure, 2020, Circulation
  • Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure, 2022, Nature Reviews Cardiology
  • Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology, 2021, Cardiovascular Research
  • Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation, 2020, Pharmacology & Therapeutics
  • Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects, 2020, Basic Research in Cardiology

Their frequent coauthors include Grégoire Vandecasteele, Delphine Mika, Jérôme Leroy, Audrey Varin, and Florence Lefebvre.

Common venues for publication are Archives of Cardiovascular Diseases Supplements, Journal of Molecular and Cellular Cardiology, bioRxiv (Cold Spring Harbor Laboratory), Circulation, and Cardiovascular Research.

These publication venues reflect the interdisciplinary nature of their work, spanning cardiovascular disease research and molecular and cellular cardiology topics.

Rodolphe Fischmeister was recognized as a Member of the Academia Europaea in 2007.

Best Publications

  • Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

    Pierre-Francois Mery;Suzanne M. Lohmann;Ulrich Walter;Rodolphe Fischmeister

  • Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation.

    P F Méry;C Pavoine;L Belhassen;F Pecker

  • cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.

    Jonas Jurevicius;Rodolphe Fischmeister

  • Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells

    H C Hartzell;R Fischmeister

  • Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes

    Liliana R.V. Castro;Ignacio Verde;Dermot M.F. Cooper;Rodolphe Fischmeister

  • Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation.

    Hartzell Hc;Méry Pf;Fischmeister R;Szabo G

  • Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

    R Fischmeister;H C Hartzell

  • The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

    Laetitia Pereira;Mélanie Métrich;María Fernández-Velasco;María Fernández-Velasco;Alexandre Lucas

  • Cyclic guanosine 3',5'-monophosphate regulates the calcium current in single cells from frog ventricle.

    R Fischmeister;H C Hartzell

  • Nitric oxide regulates the calcium current in isolated human atrial myocytes.

    Michael Kirstein;Michèle Rivet-Bastide;Stéphane Hatem;Agnès Bénardeau

  • Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca2+ current in rat ventricular myocytes

    Ignacio Verde;Greégoire Vandecasteele;Frank Lezoualc'h;Rodolphe Fischmeister

  • Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes

    Jérôme Leroy;Aniella Abi-Gerges;Viacheslav O. Nikolaev;Wito Richter

  • Signal transduction by cGMP in heart.

    S M Lohmann;R Fischmeister;U Walter

  • Cyclic GMP regulation of the L-type Ca2+ channel current in human atrial myocytes

    Grégoire Vandecasteele;Ignacio Verde;Catherine Rücker-Martin;Patrick Donzeau-Gouge

  • Treatments targeting inotropy.

    Christoph Maack;Thomas Eschenhagen;Nazha Hamdani;Frank R Heinzel

  • A Specific Pattern of Phosphodiesterases Controls the cAMP Signals Generated by Different Gs-Coupled Receptors in Adult Rat Ventricular Myocytes

    Francesca Rochais;Aniella Abi-Gerges;Kathleen Horner;Florence Lefebvre

  • Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase

    Grégoire Vandecasteele;Thomas Eschenhagen;Hasso Scholz;Birgitt Stein

  • Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

    Francesca Rochais;Grégoire Vandecasteele;Florence Lefebvre;Claire Lugnier

  • Cloning, Expression, and Pharmacology of Four Human 5-Hydroxytryptamine4 Receptor Isoforms Produced by Alternative Splicing in the Carboxyl Terminus

    Olivier Blondel;Monique Gastineau;Monique Gastineau;Yamina Dahmoune;Yamina Dahmoune;Michel Langlois;Michel Langlois

  • Calcium-mediated inactivation of the calcium conductance in cesium-loaded frog heart cells.

    D Mentrard;G Vassort;R Fischmeister

Frequent Co-Authors

Viacheslav O. Nikolaev
Viacheslav O. Nikolaev Universität Hamburg
Johan Hoebeke
Johan Hoebeke Centre national de la recherche scientifique, CNRS
Dobromir Dobrev
Dobromir Dobrev University of Duisburg-Essen
Thomas Eschenhagen
Thomas Eschenhagen Universität Hamburg
Dermot M. F. Cooper
Dermot M. F. Cooper University of Cambridge
Emilio Hirsch
Emilio Hirsch University of Turin
Roger J. Hajjar
Roger J. Hajjar Icahn School of Medicine at Mount Sinai
Suzanne M. Lohmann
Suzanne M. Lohmann University of Würzburg
Serge Adnot
Serge Adnot Paris-Est Créteil University

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