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Emilio Hirsch

Emilio Hirsch

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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
32224
World Ranking
1760
National Ranking
26

Medicine

D-Index
98
Citations
32529
World Ranking
8968
National Ranking
308

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Emilio Hirsch is affiliated with the University of Turin in Italy and has contributed extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research spans multiple subfields including Molecular Biology, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Oncology, and Cell Biology.

Their work addresses a variety of topics, notably:

  • Chemotherapy-induced cardiotoxicity and mitigation
  • Phosphodiesterase function and regulation
  • Cellular transport and secretion
  • PI3K/AKT/mTOR signaling in cancer
  • Cardiovascular Function and Risk Factors
  • Heart Failure Treatment and Management
  • Cardiac electrophysiology and arrhythmias

Emilio Hirsch has published papers in several prominent scientific journals and frequently contributes to:

  • Cardiovascular Research
  • European Heart Journal
  • Vascular Pharmacology
  • Circulation
  • bioRxiv (Cold Spring Harbor Laboratory)

Some recent notable publications include:

  • Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer, 2021, Cancers
  • Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function, 2020, Cardiovascular Research
  • Preventing and Treating Anthracycline Cardiotoxicity: New Insights, 2020, The Annual Review of Pharmacology and Toxicology
  • Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs, 2020, Cancer Research
  • Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?, 2020, Frontiers in Cardiovascular Medicine

Collaboration plays a significant role in their research output, with frequent co-authors including Alessandra Ghigo, Lorenzo Prever, Federico Gulluni, Michele Russo, and Jean Piero Margaria.

Best Publications

  • Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

    Emilio Hirsch;Vladimir L. Katanaev;Cecilia Garlanda;Ornella Azzolino

  • PI3K/AKT signaling pathway and cancer: an updated review.

    Miriam Martini;Maria Chiara De Santis;Laura Braccini;Federico Gulluni

  • Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

    Montserrat Camps;Thomas Rückle;Hong Ji;Vittoria Ardissone

  • Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

    Cecilia Garlanda;Emilio Hirsch;Silvia Bozza;Antonietta Salustri

  • Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

    Michael A. Crackower;Gavin Y. Oudit;Ivona Kozieradzki;Ivona Kozieradzki;Renu Sarao;Renu Sarao

  • PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

    Enrico Patrucco;Antonella Notte;Laura Barberis;Giulio Selvetella

  • PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.

    Antonietta Salustri;Cecilia Garlanda;Emilio Hirsch;Marika De Acetis

  • Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.

    Thomas Eschenhagen;Thomas Force;Michael S. Ewer;Gilles W. De Keulenaer

  • Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

    York Posor;Marielle Eichhorn-Gruenig;Dmytro Puchkov;Johannes Schöneberg

  • Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins.

    Emilio Hirsch;Antonio Iglesias;Alexandra J. Potocnik;Ursula Hartmann

  • Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

    Sebastian R. Nielsen;Valeria Quaranta;Andrea Linford;Perpetua Emeagi

  • Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

    Michael C. Schmid;Christie J. Avraamides;Holly C. Dippold;Irene Franco

  • Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

    Muriel Laffargue;Ronan Calvez;Peter Finan;Alexandre Trifilieff

  • Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

    Alison M. Condliffe;Keith Davidson;Karen E. Anderson;Chris D. Ellson

  • Melusin, a muscle-specific integrin β1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

    Mara Brancaccio;Luigi Fratta;Antonella Notte;Emilio Hirsch

  • Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

    Cecilia Garlanda;Federica Riva;Nadia Polentarutti;Chiara Buracchi

  • Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

    Elisa Ciraolo;Manuela Iezzi;Romina Marone;Stefano Marengo

  • PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis

    G John Ferguson;Laura Milne;Suhasini Kulkarni;Takehiko Sasaki

  • Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

    Stephane Heymans;Emilio Hirsch;Stefan D. Anker;Pal Aukrust

  • Phosphoinositide 3-kinase signalling in the vascular system

    Fulvio Morello;Alessia Perino;Emilio Hirsch

Frequent Co-Authors

Fiorella Altruda
Fiorella Altruda University of Turin
Matthias P. Wymann
Matthias P. Wymann University of Basel
Lorenzo Silengo
Lorenzo Silengo University of Turin
Alberto Mantovani
Alberto Mantovani Humanitas University
Stephane Heymans
Stephane Heymans Maastricht University
Roberto Chiarle
Roberto Chiarle Harvard University
Thomas Thum
Thomas Thum Hannover Medical School
Cecilia Garlanda
Cecilia Garlanda Humanitas University
Guido Tarone
Guido Tarone University of Turin
Marco Falasca
Marco Falasca Curtin University

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