World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
13411
World Ranking
13083
National Ranking
5580

Overview

Roberto Chiarle is affiliated with Harvard University in the United States and has an extensive publication record primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work focuses significantly on Molecular Biology, Oncology, Pathology and Forensic Medicine, Pulmonary and Respiratory Medicine, and Immunology.

Their research covers various topics including Lymphoma Diagnosis and Treatment, Lung Cancer Treatments and Mutations, CAR-T cell therapy research, Cancer Genomics and Diagnostics, Lung Cancer Research Studies, RNA modifications and cancer, and Neuroblastoma Research and Treatments.

Roberto Chiarle's frequent co-authors include Claudia Voena, Chiara Ambrogio, Taek-Chin Cheong, Carlo Gambacorti-Passerini, and Elisa Bergaggio.

The scientist has published frequently in the following venues:

  • Cancer Research
  • Blood
  • Nature Communications
  • Regular and Young Investigator Award Abstracts
  • Blood Advances

Recent papers by Roberto Chiarle reflect a focus on genetic editing technologies, cancer mechanisms, and microenvironment interactions. Examples include:

  • Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing, 2023, Nature Communications
  • ERα-associated translocations underlie oncogene amplifications in breast cancer, 2023, Nature
  • Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites, 2022, Nature Communications
  • SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment, 2023, Cancer Discovery
  • Dissecting ELANE neutropenia pathogenicity by human HSC gene editing, 2021, Cell stem cell

Best Publications

  • The anaplastic lymphoma kinase in the pathogenesis of cancer.

    Roberto Chiarle;Claudia Voena;Chiara Ambrogio;Roberto Piva;Roberto Piva

  • Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

    Nicola Crosetto;Abhishek Mitra;Maria Joao Silva;Magda Bienko;Magda Bienko

  • Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

    Roberto Chiarle;William J Simmons;Honjying Cai;Girish Dhall

  • Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

    Roberto Chiarle;Yu Zhang;Richard L. Frock;Susanna M. Lewis

  • Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

    Alberto Zamo;Roberto Chiarle;Roberto Piva;Jennifer Howes

  • Role of the F-box protein Skp2 in lymphomagenesis.

    Esther Latres;Roberto Chiarle;Brenda A. Schulman;Nikola P. Pavletich

  • The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo

    Florian A. Karreth;Markus Reschke;Anna Ruocco;Christopher Ng

  • The STAT3 isoforms alpha and beta have unique and specific functions.

    Diego Maritano;Michelle L Sugrue;Michelle L Sugrue;Silvia Tininini;Sarah Dewilde

  • NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.

    Roberto Chiarle;Jerald Z. Gong;Ilaria Guasparri;Anna Pesci

  • FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

    Shanshan Duan;Lukas Cermak;Julia K. Pagan;Mario Rossi

  • Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.

    Roberto Chiarle;Leo M. Budel;Jeffrey Skolnik;Glauco Frizzera

  • Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

    Leticia Miravalle;Takahiko Tokuda;Roberto Chiarle;Giorgio Giaccone

  • KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.

    Chiara Ambrogio;Jens Köhler;Zhi Wei Zhou;Haiyun Wang

  • Simple and Rapid In Vivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology

    Rafael B Blasco;Elif Karaca;Chiara Ambrogio;Taek Chin Cheong

  • CD30 in normal and neoplastic cells.

    Roberto Chiarle;A Podda;G Prolla;J Gong

  • Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes

    Monica Gostissa;Frederick W. Alt;Roberto Chiarle

  • Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes

    Roberto Piva;Elisa Pellegrino;Michela Mattioli;Luca Agnelli

  • Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas

    Roberto Piva;Roberto Chiarle;Roberto Chiarle;Andrea D. Manazza;Andrea D. Manazza;Riccardo Taulli;Riccardo Taulli

  • New and old functions of STAT3: a pivotal target for individualized treatment of cancer.

    Giorgio Inghirami;Roberto Chiarle;William J Simmons;Roberto Piva

  • S-Phase Kinase-Associated Protein 2 Expression in Non-Hodgkin's Lymphoma Inversely Correlates with p27 Expression and Defines Cells in S Phase

    Roberto Chiarle;Yan Fan;Roberto Piva;Hugo Boggino

Frequent Co-Authors

Giorgio Inghirami
Giorgio Inghirami Cornell University
Francesco Novelli
Francesco Novelli University of Turin
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Michele Pagano
Michele Pagano New York University
Emilio Hirsch
Emilio Hirsch University of Turin
Mirella Giovarelli
Mirella Giovarelli University of Turin
Federica Cavallo
Federica Cavallo University of Turin
Carlo Gambacorti-Passerini
Carlo Gambacorti-Passerini University of Milano-Bicocca
Ole Nørregaard Jensen
Ole Nørregaard Jensen University of Southern Denmark
Valeria Poli
Valeria Poli University of Turin

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