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Francesco Novelli

Francesco Novelli

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
10679
World Ranking
12726
National Ranking
383

Overview

Francesco Novelli is affiliated with the University of Turin in Italy. Novelli's research spans a number of fields primarily grounded in medicine, biochemistry, genetics, and molecular biology, with significant emphasis on immunology and microbiology. Their work addresses key subfields such as oncology, immunology, molecular biology, biotechnology, and epidemiology.

Novelli's research focuses extensively on pancreatic and hepatic oncology, immunotherapy and immune responses, cancer immunotherapy and biomarkers, as well as broader cancer research and treatments. They also investigate the roles of immune cells in cancer, cancer-related hypoxia and metabolism, and aspects of phagocytosis and immune regulation.

Recent notable publications include:

  • IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer (2023, Nature)
  • In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination (2020, Journal for ImmunoTherapy of Cancer)
  • IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions (2021, Proceedings of the National Academy of Sciences)
  • Post-Translational Modifications in Tumor-Associated Antigens as a Platform for Novel Immuno-Oncology Therapies (2022, Cancers)
  • The dark side of immunotherapy: pancreatic cancer (2020, Cancer Drug Resistance)

Frequent collaborators in Novelli's research include Paola Cappello, Silvia Brugiapaglia, Claudia Curcio, Alessandro Scagliotti, and Rosella Spadi. These collaborations have contributed to a sustained body of work in cancer research and immunotherapy.

Publication venues where Novelli has regularly contributed are:

  • Pancreatology
  • Cancers
  • Regular and Young Investigator Award Abstracts
  • Journal of Experimental & Clinical Cancer Research
  • Frontiers in Immunology

Best Publications

  • T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β†

    Luca Durelli;Laura Conti;Marinella Clerico;Daniela Boselli

  • A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

    Gilles Courtois;Asma Smahi;Janine Reichenbach;Rainer Döffinger

  • Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential

    L Valfrè di Bonzo;I Ferrero;C Cravanzola;K Mareschi

  • Regulation of Human Macrophage M1-M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1.

    Federica Raggi;Simone Pelassa;Daniele Pierobon;Federica Penco

  • STAT1 and STAT3 in tumorigenesis: A matter of balance.

    Lidia Avalle;Sara Pensa;Gabriella Regis;Francesco Novelli

  • α-Enolase: a promising therapeutic and diagnostic tumor target.

    Michela Capello;Sammy Ferri-Borgogno;Paola Cappello;Francesco Novelli

  • Macrophage PI3Kγ drives pancreatic ductal adenocarcinoma progression

    Megan M. Kaneda;Paola Cappello;Abraham V. Nguyen;Natacha Ralainirina

  • Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

    Gabriella Regis;Sara Pensa;Daniela Boselli;Francesco Novelli

  • Distribution of interferon-γ receptor in human tissues

    Guido Valente;Laurence Ozmen;Francesco Novelli;Massimo Geuna

  • Interferon‐γ receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death

    Paola Bernabei;Eliana M. Coccia;Laura Rigamonti;Marita Bosticardo

  • Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

    Giovanni Francesco Castino;Nina Cortese;Giovanni Capretti;Simone Serio

  • Partial Interferon-γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette-Guérin and Mycobacterium abscessus Infection

    Rainer Döffinger;Emmanuelle Jouanguy;Stéphanie Dupuis;Marie Claude Fondanèche

  • Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth

    Mingchuan Li;Valentina Sala;Maria Chiara De Santis;James Cimino

  • Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways.

    Rafael Barreto;Giorgia Mandili;Frank A. Witzmann;Francesco Novelli

  • The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice

    Simona Rolla;Elisa Alchera;Chiara Imarisio;Valentina Bardina

  • An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.

    F Pericle;M Giovarelli;M P Colombo;G Ferrari

  • Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

    Maria Carla Bosco;Daniele Pierobon;Fabiola Blengio;Federica Raggi

  • The role of IL-12, IL-23 and IFN-γ in immunity to viruses

    Francesco Novelli;Jean-Laurent Casanova

  • Switching on of the proliferation or apoptosis of activated human T lymphocytes by IFN-gamma is correlated with the differential expression of the alpha- and beta-chains of its receptor.

    Francesco Novelli;Paola Bernabei;Laurence Ozmen;Laura Rigamonti

  • in vitro and in vivo

    Gabriella Regis;Marita Bosticardo;Laura Conti;Stefania De Angelis

Frequent Co-Authors

Mirella Giovarelli
Mirella Giovarelli University of Turin
Guido Forni
Guido Forni University of Turin
Emanuel F. Petricoin
Emanuel F. Petricoin George Mason University
Lance A. Liotta
Lance A. Liotta George Mason University
Roberto Chiarle
Roberto Chiarle Harvard University
Chiara Riganti
Chiara Riganti University of Turin
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Daniele Giordano
Daniele Giordano University of Turin
Massimo Massaia
Massimo Massaia University of Turin
Federica Cavallo
Federica Cavallo University of Turin

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