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Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
156
Citations
96899
World Ranking
100
National Ranking
63

Medicine

D-Index
155
Citations
96257
World Ranking
958
National Ranking
549

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2016 - The Walter E. Stamm Mentor Award, Infectious Diseases Society of America
  • 2014 - Distinguished Service Award, Clinical Immunology Society
  • 2012 - Presidential Award, Clinical Immunology Society
  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Steven M. Holland is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research focuses primarily on the fields of medicine, immunology and microbiology, and biochemistry, genetics and molecular biology.

Their subfields of study include immunology, infectious diseases, epidemiology, genetics, and molecular biology. Key topics covered in their work are immunodeficiency and autoimmune disorders, neutrophil, myeloperoxidase and oxidative mechanisms, blood disorders and treatments, Mycobacterium research and diagnosis, SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, and fungal infections and studies.

Frequent publication venues where their work appears include the Journal of Clinical Immunology, Journal of Allergy and Clinical Immunology, Blood, bioRxiv (Cold Spring Harbor Laboratory), and Blood Advances.

Notable frequent co-authors in their collaborations are Christa S. Zerbe, Amy P. Hsu, Michail S. Lionakis, Luigi D. Notarangelo, and Alexandra F. Freeman.

Significant recent papers include:

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19, 2020, Science
  • Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee, 2020, Journal of Clinical Immunology
  • Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee, 2022, Journal of Clinical Immunology
  • Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification, 2020, Journal of Clinical Immunology
  • Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, 2021, Science Immunology

Steven M. Holland has received several professional recognitions, including the Walter E. Stamm Mentor Award from the Infectious Diseases Society of America in 2016, the Distinguished Service Award from the Clinical Immunology Society in 2014, the Presidential Award from the Clinical Immunology Society in 2012, and was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2003.

Best Publications

  • An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.

    David E. Griffith;Timothy Aksamit;Barbara A. Brown-Elliott;Antonino Catanzaro

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

    Paul Bastard;Paul Bastard;Paul Bastard;Lindsey B. Rosen;Qian Zhang;Eleftherios Michailidis

  • Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

    Ulf Landmesser;Sergey Dikalov;S. Russ Price;Louise McCann

  • Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

    Joshua D. Milner;Jason M. Brenchley;Jason M. Brenchley;Arian Laurence;Alexandra F. Freeman

  • STAT3 Mutations in the Hyper-IgE Syndrome

    Steven M. Holland;Frank R. DeLeo;Houda Z. Elloumi;Amy P. Hsu

  • Activated STING in a Vascular and Pulmonary Syndrome

    Y. Liu;A.A. Jesus;B. Marrero;D. Yang

  • Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

    Stuart G. Tangye;Waleed Al-Herz;Aziz Bousfiha;Talal Chatila

  • JAKs and STATs in Immunity, Immunodeficiency, and Cancer

    John J O'Shea;Steven M Holland;Louis M Staudt

  • Genetic, biochemical, and clinical features of chronic granulomatous disease

    Brahm H. Segal;Thomas L. Leto;John I. Gallin;Harry L. Malech

  • Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

    Raphaela Goldbach-Mansky;Natalie J Dailey;Scott W Canna;Ana Gelabert

  • Hyper-IgE Syndrome with Recurrent Infections — An Autosomal Dominant Multisystem Disorder

    Bodo Grimbacher;Steven M. Holland;John I. Gallin;Frank Greenberg

  • X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.

    Rainer Döffinger;Asma Smahi;Christine Bessia;Frédéric Geissmann

  • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

    Hye Sun Kuehn;Weiming Ouyang;Bernice Lo;Elissa K. Deenick;Elissa K. Deenick

  • International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

    Capucine Picard;H. Bobby Gaspar;Waleed Al-Herz;Aziz Bousfiha

  • Phanerozoic trends in the global diversity of marine invertebrates.

    John Alroy;Martin Aberhan;David J. Bottjer;Michael Foote

  • Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015

    Capucine Picard;Waleed Al-Herz;Aziz Bousfiha;Jean Laurent Casanova

  • Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries.

    Jennifer Adjemian;Kenneth N. Olivier;Amy E. Seitz;Steven M. Holland

  • Combined Immunodeficiency Associated with DOCK8 Mutations

    Qian Zhang;Jeremiah C. Davis;Ian T. Lamborn;Alexandra F. Freeman

  • Chronic Granulomatous Disease

    Steven M. Holland

  • GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity

    Michael A. Spinner;Lauren A. Sanchez;Amy P. Hsu;Pamela A. Shaw

  • Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.

    Stéphanie Dupuis;Catherine Dargemont;Claire Fieschi;Nicolas Thomassin

  • A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

    Emmanuelle Jouanguy;Salma Lamhamedi-Cherradi;David Lammas;Susan E. Dorman

  • Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

    Amy P. Hsu;Elizabeth P. Sampaio;Javed Khan;Katherine R. Calvo

  • ROLE OF P47(PHOX) IN VASCULAR OXIDATIVE STRESS AND HYPERTENSION CAUSED BY ANGIOTENSIN II

    Ulf Landmesser;Hua Cai;Sergey Dikalov;Louise McCann

Frequent Co-Authors

Alexandra F. Freeman
Alexandra F. Freeman National Institute of Allergy and Infectious Diseases
Amy P. Hsu
Amy P. Hsu National Institutes of Health
Gulbu Uzel
Gulbu Uzel National Institute of Allergy and Infectious Diseases
Harry L. Malech
Harry L. Malech National Institutes of Health
Elizabeth P. Sampaio
Elizabeth P. Sampaio National Institutes of Health
Kenneth N. Olivier
Kenneth N. Olivier National Institutes of Health
John I. Gallin
John I. Gallin National Institutes of Health
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Douglas B. Kuhns
Douglas B. Kuhns National Institutes of Health
Sergio D. Rosenzweig
Sergio D. Rosenzweig National Institutes of Health

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