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Immunology

D-Index
106
Citations
39753
World Ranking
567
National Ranking
338

Medicine

D-Index
106
Citations
41364
World Ranking
6540
National Ranking
3473

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Harry L. Malech is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields with a strong emphasis on Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these areas, specific subfields of study include Immunology, Genetics, Molecular Biology, Oncology, and Epidemiology.

The scientist's work covers a diverse range of topics, reflecting a focus on cellular and molecular mechanisms related to immune function and genetic therapies. Key topics of their research include:

  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Immunodeficiency and Autoimmune Disorders
  • CRISPR and Genetic Engineering
  • Immune Cell Function and Interaction
  • Cytomegalovirus and herpesvirus research

Recent publications highlight work in gene therapy and immunology, including studies on genetic treatment approaches and cellular differentiation tools. Notable recent papers include:

  • Lentiviral gene therapy for X-linked chronic granulomatous disease, 2020, Nature Medicine
  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency, 2021, New England Journal of Medicine
  • Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia, 2020, Blood Advances
  • Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells, 2021, Blood
  • Lentiviral Gene Therapy for Artemis-Deficient SCID, 2022, New England Journal of Medicine

Frequent collaborators in Malech's research include:

  • Suk See De Ravin
  • Elizabeth M. Kang
  • Steven M. Holland
  • Luigi D. Notarangelo
  • Christa S. Zerbe

Prominent publication venues where Malech's research frequently appears are:

  • Blood
  • Journal of Clinical Immunology
  • Transplantation and Cellular Therapy
  • Journal of Allergy and Clinical Immunology
  • New England Journal of Medicine

Their body of work includes nearly a hundred publications in Medicine, complemented by extensive work in related biomedical sciences. Recognition in their professional community includes membership in the Association of American Physicians.

Best Publications

  • Chronic granulomatous disease. Report on a national registry of 368 patients.

    Jerry A. Winkelstein;Mary C. Marino;Richard B. Johnston;John Boyle

  • Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

    Christian Lood;Luz P Blanco;Monica M Purmalek;Carmelo Carmona-Rivera

  • STAT3 Mutations in the Hyper-IgE Syndrome

    Steven M. Holland;Frank R. DeLeo;Houda Z. Elloumi;Amy P. Hsu

  • Current concepts: immunology; neutrophils in human diseases

    Harry L. Malech;John I. Gallin

  • Genetic, biochemical, and clinical features of chronic granulomatous disease

    Brahm H. Segal;Thomas L. Leto;John I. Gallin;Harry L. Malech

  • Hyper-IgE Syndrome with Recurrent Infections — An Autosomal Dominant Multisystem Disorder

    Bodo Grimbacher;Steven M. Holland;John I. Gallin;Frank Greenberg

  • A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease

    J. I. Gallin;H. L. Malech;W. J. T. Curnutte;P. G. Quie

  • Residual NADPH oxidase and survival in chronic granulomatous disease.

    Douglas B. Kuhns;W. Gregory Alvord;Theo Heller;Jordan J. Feld

  • Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes.

    S.J. Vowells;S. Sekhsaria;H.L. Malech;M. Shalit

  • Gastrointestinal involvement in chronic granulomatous disease.

    Beatriz E Marciano;Sergio D Rosenzweig;David E Kleiner;Victoria L Anderson

  • Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase

    Daniel Rotrosen;Choh L. Yeung;Thomas L. Leto;Harry L. Malech

  • The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators

    Michael Centola;Geryl Wood;David M. Frucht;Jerome Galon

  • Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.

    Myron S. Cohen;Raul E. Isturiz;Harry L. Malech;Richard K. Root

  • Itraconazole to prevent fungal infections in chronic granulomatous disease.

    John I Gallin;David W Alling;Harry L Malech;Robert Wesley

  • Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4

    Bodo Grimbacher;Alejandro A. Schäffer;Steven M. Holland;Joie Davis

  • Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

    Thomas L. Leto;Karen J. Lomax;Bryan D. Volpp;Hiroyuki Nunoi

  • Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.

    Hetal Pandya;Michael J Shen;David M Ichikawa;Andrea B Sedlock

  • Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease

    Karen J. Lomax;Thomas L. Leto;Hiroyuki Nunoi;John I. Gallin

  • Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

    Hiroyuki Nunoi;Daniel Rotrosen;John I. Gallin;Harry L. Malech

  • Common Severe Infections in Chronic Granulomatous Disease

    Beatriz E. Marciano;Christine Spalding;Alan Fitzgerald;Daphne Mann

  • Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

    P Goldsmith;P Gierschik;G Milligan;C G Unson

  • Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease

    Harry L. Malech;Phillip B. Maples;Narda Whiting-Theobald;Gilda F. Linton

Frequent Co-Authors

John I. Gallin
John I. Gallin National Institutes of Health
Steven M. Holland
Steven M. Holland National Institute of Allergy and Infectious Diseases
Douglas B. Kuhns
Douglas B. Kuhns National Institutes of Health
Steven M. Holland
Steven M. Holland University of Georgia
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco
Theo Heller
Theo Heller National Institutes of Health
Thomas L. Leto
Thomas L. Leto National Institutes of Health
Thomas A. Fleisher
Thomas A. Fleisher National Institutes of Health
Morton J. Cowan
Morton J. Cowan University of California, San Francisco
Philip M. Murphy
Philip M. Murphy National Institutes of Health

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