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Biology and Biochemistry
Netherlands
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
41168
World Ranking
653
National Ranking
8

Medicine

D-Index
120
Citations
41333
World Ranking
3791
National Ranking
147

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2025 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Dirk Roos is affiliated with the University of Amsterdam in the Netherlands. Their research spans multiple intersecting fields, prominently within Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. Roos's work focuses largely on Immunology, Molecular Biology, Immunology and Allergy, Genetics, and Hematology as subfields.

The primary topics explored in Roos's research include Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Cell Adhesion Molecules Research, Blood disorders and treatments, Inflammasome and immune disorders, Platelet Disorders and Treatments, Immunodeficiency and Autoimmune Disorders, and RNA Research and Splicing.

Recent publications by Roos include the following papers:

  • Hematologically important mutations: X-linked chronic granulomatous disease (fourth update), 2021, Blood Cells Molecules and Diseases
  • Hematologically important mutations: The autosomal forms of chronic granulomatous disease (third update), 2021, Blood Cells Molecules and Diseases
  • Mutations in cis that affect mRNA synthesis, processing and translation, 2021, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • Hematologically important mutations: Leukocyte adhesion deficiency (second update), 2023, Blood Cells Molecules and Diseases
  • Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey, 2021, Clinical & Experimental Immunology

Roos frequently publishes in the following venues:

  • Blood Cells Molecules and Diseases
  • Journal of Clinical Immunology
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • Clinical & Experimental Immunology
  • International Archives of Allergy and Immunology

Collaboration is a significant aspect of Roos's research activity. Frequent co-authors include Karin van Leeuwen, Martin de Boer, Mustafa Yavuz Köker, Deniz Çağdaş, and İlhan Tezcan.

Best Publications

  • FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype

    H. R. Koene;M. Kleijer;J. Algra;D. Roos

  • Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

    I M Goldstein;D Roos;H B Kaplan;G Weissmann

  • Chronic Granulomatous Disease: The European Experience

    J. Merlijn van den Berg;Elsbeth van Koppen;Anders Åhlin;Bernd H. Belohradsky

  • Neutrophils: Between host defence, immune modulation, and tissue injury

    Philipp Kruger;Mona Saffarzadeh;Alexander N. R. Weber;Nikolaus Rieber

  • Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro

    C. H. E. Homburg;M. De Haas;A. E. G. K. Von Dem Borne;A. J. Verhoeven

  • Monitoring human basophil activation via CD63 monoclonal antibody 435.

    Edward F. Knol;Frederik P.J. Mul;Hans Jansen;Jero Calafat

  • Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

    Daniel R. Ambruso;Cindy Knall;Amy N. Abell;Julie Panepinto

  • Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation.

    T.W. Kuijpers;A.T.J. Tool;C.E. van der Schoot;L.A. Ginsel

  • The Pi-linked receptor FcRIII is released on stimulation of neutrophils

    T. W. Huizinga;C. E. van der Schoot;C. Jost;R. Klaassen

  • Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

    D Roos;M de Boer;F Kuribayashi;C Meischl

  • Brominating oxidants generated by human eosinophils

    Stephen J. Weiss;Samuel T. Test;Carel M. Eckmann;Dirk Roos

  • Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis

    N A Maianski;J Geissler;S M Srinivasula;E S Alnemri

  • Oxidative killing of microbes by neutrophils.

    Dirk Roos;Robin van Bruggen;Christof Meischl

  • Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes

    Henk-Jan van Manen;Yvonne M. Kraan;Dirk Roos;Cees Otto

  • Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease.

    Dominik Hartl;Dominik Hartl;Philipp Latzin;Peter Hordijk;Veronica Marcos

  • Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis.

    Hanke L Matlung;Liane Babes;Xi Wen Zhao;Michel van Houdt

  • Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes.

    Weening Rs;Wever R;Roos D

  • Characterization and quantification of the peroxidase in human monocytes.

    Arthur Bos;Ron Wever;Dirk Roos

  • Neutrophil Fc gamma RIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families.

    M. De Haas;M. Kleijer;R. Van Zwieten;D. Roos

  • Functional activity of enucleated human polymorphonuclear leukocytes.

    D Roos;A A Voetman;L J Meerhof

Frequent Co-Authors

Taco W. Kuijpers
Taco W. Kuijpers University of Amsterdam
Arthur J. Verhoeven
Arthur J. Verhoeven University of Amsterdam
Timo K. van den Berg
Timo K. van den Berg Radboud University
Edward F. Knol
Edward F. Knol Utrecht University
Dominik Hartl
Dominik Hartl Novartis (Switzerland)
Leo Koenderman
Leo Koenderman Utrecht University
Ozden Sanal
Ozden Sanal Hacettepe University
Bernd H. Belohradsky
Bernd H. Belohradsky Ludwig-Maximilians-Universität München
A. E. G. K. Von Dem Borne
A. E. G. K. Von Dem Borne University of Amsterdam

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