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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
14434
World Ranking
11862
National Ranking
915

Overview

Alex N. Bullock is affiliated with the University of Oxford in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a significant emphasis on molecular mechanisms related to disease and development.

The primary fields of study in their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these domains, their subfields of focus are:

  • Molecular Biology
  • Oncology
  • Genetics
  • Pulmonary and Respiratory Medicine
  • Immunology

The main topics addressed in Alex N. Bullock's publications are diverse and cover:

  • Ubiquitin and proteasome pathways
  • Cancer-related Molecular Pathways
  • TGF-β signaling in diseases
  • Glioma Diagnosis and Treatment
  • Heterotopic Ossification and Related Conditions
  • Genomics, phytochemicals, and oxidative stress
  • Microtubule and mitosis dynamics

Frequent venues for publication include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Zenodo (CERN European Organization for Nuclear Research)
  • RSC Medicinal Chemistry
  • Biomedicines

Recent representative papers illustrate the range and focus of their research:

  • Ubiquitin ligases: guardians of mammalian development, 2022, Nature Reviews Molecular Cell Biology
  • Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas, 2020, Cancer Cell
  • Target 2035 - update on the quest for a probe for every protein, 2021, RSC Medicinal Chemistry
  • Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease, 2021, Cellular and Molecular Gastroenterology and Hepatology
  • Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva, 2021, JCI Insight

Their research network includes frequent collaboration with several coauthors, notably:

  • Jong Fu Wong
  • Zhuoyao Chen
  • Eleanor Williams
  • Stefan Knapp
  • William Richardson

Alex N. Bullock's extensive publication record reflects ongoing contributions to studies on molecular pathways critical to development, cancer, and inflammatory diseases. Their work engages with both fundamental molecular biology and translational aspects relevant to therapy and diagnosis.

Best Publications

  • Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

    Kirsty S. Hewitson;Luke A. McNeill;Madeline V. Riordan;Ya-Min Tian

  • Rescuing the function of mutant p53

    Alex N. Bullock;Alan R. Fersht

  • Targeted protein degradation: expanding the toolbox.

    Matthieu Schapira;Matthieu Schapira;Matthew F Calabrese;Alex N Bullock;Craig M Crews

  • Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

    Alex N Bullock;Julia Henckel;Alan R Fersht

  • Thermodynamic stability of wild-type and mutant p53 core domain

    Alex N. Bullock;Julia Henckel;Brian S. DeDecker;Christopher M. Johnson

  • Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

    Kathryn R Taylor;Alan Mackay;Nathalène Truffaux;Yaron S Butterfield

  • Structural basis of Keap1 interactions with Nrf2.

    Peter Canning;Fiona J. Sorrell;Alex N. Bullock

  • A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

    Oleg Fedorov;Brian Marsden;Vanda Pogacic;Peter Rellos

  • The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

    Sonja Baumli;Graziano Lolli;Edward D Lowe;Sonia Troiani

  • CIS is a potent checkpoint in NK cell–mediated tumor immunity

    Rebecca B. Delconte;Tatiana B Kolesnik;Laura F. Dagley;Laura F. Dagley;Jai Rautela;Jai Rautela

  • Computational redesign of protein-protein interaction specificity.

    Tanja Kortemme;Lukasz A Joachimiak;Lukasz A Joachimiak;Alex N Bullock;Alex N Bullock;Aaron D Schuler

  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

    Tinghu Zhang;Nicholas Kwiatkowski;Nicholas Kwiatkowski;Calla M Olson;Sarah E Dixon-Clarke

  • Ruthenium half-sandwich complexes bound to protein kinase Pim-1.

    Judit É. Debreczeni;Alex N. Bullock;G. Ekin Atilla;Douglas S. Williams

  • Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

    Peter Canning;Christopher D.O. Cooper;Tobias Krojer;James W. Murray

  • Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

    Chitra A. Shintre;Ashley C. W. Pike;Qiuhong Li;Jung-In Kim

  • Structure and substrate specificity of the Pim-1 kinase.

    Alex N. Bullock;Judit Debreczeni;Ann L. Amos;Stefan Knapp

  • A new class of small molecule inhibitor of BMP signaling.

    Caroline E. Sanvitale;Georgina Kerr;Apirat Chaikuad;Marie-Christine Ramel

  • Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity

    Vanda Pogacic;Alex N. Bullock;Oleg Fedorov;Panagis Filippakopoulos

  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

    Tinghu Zhang;Nicholas Kwiatkowski;Calla M Olson;Sarah E Dixon-Clarke

  • Thermodynamic stability of wild-type and mutant p53 core domain (tumor suppressorydenaturationyfoldingyzincyprotein)

    Alex N. Bullock;Julia Henckel;Brian S. Dedecker;Christopher M. Johnson

Frequent Co-Authors

Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
Oleg Fedorov
Oleg Fedorov University of Oxford
Opher Gileadi
Opher Gileadi Karolinska Institute
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Gregory D. Cuny
Gregory D. Cuny University of Houston
Chris Jones
Chris Jones Institute of Cancer Research
James T. Triffitt
James T. Triffitt University of Oxford

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