What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Biochemistry, Protein structure, Computational biology, Molecular biology and Signal transduction.
Alex N. Bullock has included themes like Protein hydroxylation, Hypoxia-Inducible Factor 1, Function and Protein folding in his Protein structure study.
His Computational biology research is multidisciplinary, relying on both Proteasome, Ubiquitin, Ubiquitin-Protein Ligases and Protein–protein interaction.
The various areas that he examines in his Protein–protein interaction study include Proteins metabolism and In vitro binding.
His research in Molecular biology intersects with topics in Cyclin A2, Cyclin E, Cyclin A, CDK-activating kinase and Cyclin D.
Alex N. Bullock combines subjects such as Bisindolylmaleimide, Cyclin-dependent kinase 9, Murine leukemia virus, Kinase and Enzyme inhibitor with his study of Signal transduction.
His most cited work include:
- Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family (598 citations)
- Rescuing the function of mutant p53 (459 citations)
- Thermodynamic stability of wild-type and mutant p53 core domain (331 citations)
What are the main themes of his work throughout his whole career to date?
Alex N. Bullock focuses on Crystal structure, Crystallography, Kinase, Cell biology and Domain.
His studies deal with areas such as Resolution, Stereochemistry, Protein kinase domain and Peptide as well as Crystal structure.
His study looks at the relationship between Peptide and topics such as PIM1, which overlap with Serine/threonine-specific protein kinase.
As a member of one scientific family, he mostly works in the field of Kinase, focusing on Cancer research and, on occasion, Mutant.
His research integrates issues of BMPR2, Protein structure and Ubiquitin, Ubiquitin ligase in his study of Cell biology.
His work is connected to Plasma protein binding and Binding site, as a part of Biochemistry.
He most often published in these fields:
- Crystal structure (41.67%)
- Crystallography (26.98%)
- Kinase (22.62%)
What were the highlights of his more recent work (between 2018-2021)?
- Kinase (22.62%)
- Crystal structure (41.67%)
- Cell biology (19.05%)
In recent papers he was focusing on the following fields of study:
Alex N. Bullock mainly investigates Kinase, Crystal structure, Cell biology, Crystallography and Receptor.
His studies in Kinase integrate themes in fields like Bone morphogenetic protein, ACVR1, FKBP, Signal transduction and Stereochemistry.
His work deals with themes such as Cancer research, Mutant, Neuroscience and Brain tumor childhood, which intersect with ACVR1.
His research in Cell biology is mostly concerned with Phosphorylation.
His Protein kinase domain research incorporates elements of BMPR2, Missense mutation, Loss function, Indene and Protein structure.
His Degron study combines topics from a wide range of disciplines, such as Computational biology and Peptide.
Between 2018 and 2021, his most popular works were:
- Targeted protein degradation: expanding the toolbox. (162 citations)
- ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma. (26 citations)
- Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas (14 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Kinase, Cancer research, Receptor, Cell biology and Ubiquitin.
His Kinase study integrates concerns from other disciplines, such as Alanine, Stereochemistry, Serine and Potassium channel.
His Cancer research study also includes fields such as
- ACVR1 together with Mutant,
- In vivo which connect with Cancer, Pancreatic cancer, DDR1 and Kinase activity.
Alex N. Bullock focuses mostly in the field of Receptor, narrowing it down to topics relating to Signal transduction and, in certain cases, Function, Transforming growth factor and Phosphorylation.
His Cell biology research includes themes of Nod, Nucleotide and ADME.
In the subject of general Ubiquitin, his work in Ubiquitin ligase is often linked to Architecture domain and Toolbox, thereby combining diverse domains of study.
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